Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

Evolutionary Acquisition of Cysteines Determines FOXO Paralog-Specific Redox Signaling

(2015) Marrit Putker et al.   ANTIOXIDANTS & REDOX SIGNALING

T cell responses in psoriasis and psoriatic arthritis

(2015) Marco Diani et al.   AUTOIMMUNITY REVIEWS

Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility

(2015) Kajsa Wing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production

(2015) Ia Khmaladze et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Defective B-cell proliferation and maintenance of long-term memory in patients with chronic granulomatous disease

(2015) Nicola Cotugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS

(2015) Maarten A. Ligtenberg et al.   PLoS One

Type I interferon related genes are common genes on the early stage after vaccination by meta-analysis of microarray data

(2015) Junnan Zhang et al.   Human Vaccines & Immunotherapeutics

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

(2014) Tiina Kelkka et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparison of proton channel, phagocyte oxidase, and respiratory burst levels between human eosinophil and neutrophil granulocytes

(2014) I. Kovács et al.   FREE RADICAL RESEARCH

Inflammatory manifestations in a single-center cohort of patients with chronic granulomatous disease

(2014) Alessandra Magnani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

γ-Interferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages

(2014) Dale R. Balce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral-resident natural Th17 cells and γδ T cells control opportunisticCandida albicansinfections

(2014) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NADPH Oxidase Modifies Patterns of MHC Class II-Restricted Epitopic Repertoires through Redox Control of Antigen Processing

(2014) E. R. O. Allan et al.   JOURNAL OF IMMUNOLOGY

Tryptophan catabolism is unaffected in chronic granulomatous disease

(2014) Ghassan J. Maghzal et al.   NATURE

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Hyperoxygenation Attenuated a Murine Model of Atopic Dermatitis through Raising Skin Level of ROS

(2014) Hyung-Ran Kim et al.   PLoS One

Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice

(2014) I. Khmaladze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus

(2014) Anders A Bengtsson et al.   ARTHRITIS RESEARCH & THERAPY

Bacillus Calmette-Guerin Infection in NADPH Oxidase Deficiency: Defective Mycobacterial Sequestration and Granuloma Formation

(2014) Christine Deffert et al.   PLoS Pathogens

Neuroendocrine Profile in a Rat Model of Psychosocial Stress: Relation to Oxidative Stress

(2013) Marilena Colaianna et al.   ANTIOXIDANTS & REDOX SIGNALING

Subsets of human type 2 macrophages show differential capacity to produce reactive oxygen species

(2013) Marina D. Kraaij et al.   CELLULAR IMMUNOLOGY

Neutrophils suppress γδ T-cell function

(2013) Florencia Sabbione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

(2013) Susana Romao et al.   JOURNAL OF CELL BIOLOGY

Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice

(2013) M. J. Grimm et al.   JOURNAL OF IMMUNOLOGY

Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors

(2013) Tiina Kelkka et al.   PLoS One

A Role for NADPH Oxidase in Antigen Presentation

(2013) Gail J. Gardiner et al.   Frontiers in Immunology

Enhancement of Antibody-Induced Arthritis via Toll-Like Receptor 2 Stimulation Is Regulated by Granulocyte Reactive Oxygen Species

(2012) Tiina Kelkka et al.   AMERICAN JOURNAL OF PATHOLOGY

Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells

(2012) Rikard Holmdahl et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Production in the Phagosome: Impact on Antigen Presentation in Dendritic Cells

(2012) Fiorella Kotsias et al.   ANTIOXIDANTS & REDOX SIGNALING

Disease Mechanisms in Rheumatology-Tools and Pathways: Plasmacytoid Dendritic Cells and Their Role in Autoimmune Rheumatic Diseases

(2012) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Identification of a redox-sensitive switch within the JAK2 catalytic domain

(2012) John K. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation

(2012) Matthew L. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cells

(2012) V. L. Crotzer et al.   JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections

(2012) A. Pizzolla et al.   JOURNAL OF IMMUNOLOGY

Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation

(2012) O. Sareila et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells

(2012) Christine Deffert et al.   JOURNAL OF PATHOLOGY

C-type lectin receptors orchestrate antifungal immunity

(2012) Sarah E Hardison et al.   NATURE IMMUNOLOGY

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology

(2012) S Schiavone et al.   Translational Psychiatry

Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease

(2011) Si Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats

(2011) Malin Hultqvist et al.   ANTIOXIDANTS & REDOX SIGNALING

Copy Number Variation of the Gene NCF1 Is Associated with Rheumatoid Arthritis

(2011) Lina M. Olsson et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

(2011) Zhi Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner

(2011) Joanna M Rybicka et al.   EMBO JOURNAL

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant inNCF2that results in reduced binding to RAC2

(2011) Aleixo M Muise et al.   GUT

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling

(2011) Michal Caspi Tal et al.   IMMUNOLOGICAL REVIEWS

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenic Autoreactive B Cells Are Not Negatively Selected toward Matrix Protein Collagen II

(2011) D. Cao et al.   JOURNAL OF IMMUNOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

(2011) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Granulomatous Disease: Lessons from a Rare Disorder

(2010) Brahm H. Segal et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Maintained pregnancy levels of oestrogen afford complete protection from post-partum exacerbation of collagen-induced arthritis

(2010) R. MATTSSON et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species

(2010) Angela Pizzolla et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

(2010) Motomu Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

(2010) J. M. Rybicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

(2010) J. Kwon et al.   Science Signaling

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Regulation of the interferon-α production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

(2009) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

(2009) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Crystal Structure of the Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights into Redox Regulation,

(2009) Sophia J. Tsai et al.   BIOCHEMISTRY

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells

(2009) C. Richter et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress can alter the antigenicity of immunodominant peptides

(2009) Daniela Weiskopf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Extracellular redox modulation by regulatory T cells

(2009) Zhonghua Yan et al.   Nature Chemical Biology

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production

(2008) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS AND RHEUMATISM

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION