Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques

The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation

(2015) June-Yong Lee et al.   IMMUNITY

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

(2015) Jan P. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS

(2015) Huanbin Xu et al.   JOURNAL OF IMMUNOLOGY

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Quality and quantity of T FH cells are critical for broad antibody development in SHIV AD8 infection

(2015) Takuya Yamamoto et al.   Science Translational Medicine

FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase

(2014) S. Fabre et al.   JOURNAL OF IMMUNOLOGY

Early Lymphoid Responses and Germinal Center Formation Correlate with Lower Viral Load Set Points and Better Prognosis of Simian Immunodeficiency Virus Infection

(2014) Jung Joo Hong et al.   JOURNAL OF IMMUNOLOGY

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

(2014) Haikun Wang et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells

(2014) Nengming Xiao et al.   NATURE IMMUNOLOGY

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Abortive T Follicular Helper Development Is Associated with a Defective Humoral Response in Leishmania infantum-Infected Macaques

(2014) Vasco Rodrigues et al.   PLoS Pathogens

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection

(2014) Kristin L. Boswell et al.   PLoS Pathogens

Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection

(2013) J. Scott Hale et al.   IMMUNITY

Transcriptional regulation of follicular T-helper (Tfh) cells

(2013) Xindong Liu et al.   IMMUNOLOGICAL REVIEWS

Simian Immunodeficiency Virus Infects Follicular Helper CD4 T Cells in Lymphoid Tissues during Pathogenic Infection of Pigtail Macaques

(2013) Y. Xu et al.   JOURNAL OF VIROLOGY

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine

(2012) S. Pallikkuth et al.   BLOOD

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

(2012) J. M. Brenchley et al.   BLOOD

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

Spatial Alterations between CD4+ T Follicular Helper, B, and CD8+ T Cells during Simian Immunodeficiency Virus Infection: T/B Cell Homeostasis, Activation, and Potential Mechanism for Viral Escape

(2012) J. J. Hong et al.   JOURNAL OF IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Simian immunodeficiency virus infection in rhesus macaques induces selective tissue specific B cell defects in double positive CD21+CD27+ memory B cells

(2011) Arpita Das et al.   CLINICAL IMMUNOLOGY

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

(2011) Julien van Grevenynghe et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

(2011) S.-E. Bentebibel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis

(2011) Mireille Laforge et al.   PLoS Pathogens

T cells and follicular dendritic cells in germinal center B-cell formation and selection

(2010) Carola G. Vinuesa et al.   IMMUNOLOGICAL REVIEWS

Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques

(2010) Kehmia Titanji et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control

(2010) F. Y. Yue et al.   JOURNAL OF IMMUNOLOGY

In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development

(2010) A. C. Poholek et al.   JOURNAL OF IMMUNOLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

(2010) Nishaki Mehta et al.   VACCINE

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

AIDS Progression Is Associated with the Emergence of IL-17-Producing Cells Early After Simian Immunodeficiency Virus Infection

(2009) L. Campillo-Gimenez et al.   JOURNAL OF IMMUNOLOGY

Dynamics and Consequences of IL-21 Production in HIV-Infected Individuals: A Longitudinal and Cross-Sectional Study

(2009) Alexandre Iannello et al.   JOURNAL OF IMMUNOLOGY

Evidence of Early B-Cell Dysregulation in Simian Immunodeficiency Virus Infection: Rapid Depletion of Naive and Memory B-Cell Subsets with Delayed Reconstitution of the Naive B-Cell Population

(2009) D. Kuhrt et al.   JOURNAL OF VIROLOGY

Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

(2009) L. Campillo-Gimenez et al.   JOURNAL OF VIROLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Tissue-Specific B-Cell Dysfunction and Generalized Memory B-Cell Loss during Acute SIV Infection

(2009) Sandrine Peruchon et al.   PLoS One

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

(2009) Jörn E. Schmitz et al.   PLoS Pathogens

Evidence for a Pathogenic Determinant in HIV-1 Nef Involved in B Cell Dysfunction in HIV/AIDS

(2008) Simon Swingler et al.   Cell Host & Microbe

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY