Tackling HIV and AIDS: contributions by non-human primate models

Use of broadly neutralizing antibodies for HIV-1 prevention

(2017) Amarendra Pegu et al.   IMMUNOLOGICAL REVIEWS

Effectiveness and safety of oral HIV preexposure prophylaxis for all populations

(2016) Virginia A. Fonner et al.   AIDS

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID “Meet the Experts” 2015 Workshop Summary

(2016) Ramesh Akkina et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2016) Gregory Q. Del Prete et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Microbiome alterations in HIV infection a review

(2016) Brett Williams et al.   CELLULAR MICROBIOLOGY

Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine

(2016) Kara Jensen et al.   Clinical and Vaccine Immunology

CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

(2016) Emily K. Cartwright et al.   IMMUNITY

A historical perspective: Simian AIDS-an accidental windfall

(2016) Murray Gardner   JOURNAL OF MEDICAL PRIMATOLOGY

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

(2016) Erica N. Borducchi et al.   NATURE

International AIDS Society global scientific strategy: towards an HIV cure 2016

(2016) Steven G Deeks et al.   NATURE MEDICINE

A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo

(2016) Guillermo Villegas et al.   PLoS One

Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

(2016) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

A rhesus macaque model of Asian-lineage Zika virus infection

(2016) Dawn M. Dudley et al.   Nature Communications

Nonhuman primate models for the evaluation of HIV-1 preventive vaccine strategies

(2016) Gregory Q. Del Prete et al.   Current Opinion in HIV and AIDS

Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers

(2016) Benjamin B. Policicchio et al.   PLoS Pathogens

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

(2015) Corbin G. Thompson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

(2015) Gregory Q. Del Prete et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Postexposure Prophylaxis Against Human Immunodeficiency Virus (HIV): New Guidelines From the WHO: A Perspective

(2015) Jonathan E. Kaplan et al.   CLINICAL INFECTIOUS DISEASES

HIV therapeutic vaccines: moving towards a functional cure

(2015) Geetha H Mylvaganam et al.   CURRENT OPINION IN IMMUNOLOGY

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial

(2015) Angela D. M. Kashuba et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Development of SHIVs with circulating, transmitted HIV-1 variants

(2015) Amit Sharma et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

(2015) Philip J Santangelo et al.   NATURE METHODS

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

(2015) Jean-Michel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

(2015) W. B. Williams et al.   SCIENCE

A Compartmental Pharmacokinetic Evaluation of Long-Acting Rilpivirine in HIV-Negative Volunteers for Pre-Exposure Prophylaxis

(2014) A G A Jackson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir

(2014) Diarmaid J. Murphy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Molecularly Tagged Simian Immunodeficiency Virus SIVmac239 Synthetic Swarm for Tracking Independent Infection Events

(2014) Gregory Q. Del Prete et al.   JOURNAL OF VIROLOGY

Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial

(2014) Jared M Baeten et al.   LANCET INFECTIOUS DISEASES

Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus

(2014) C. D. Andrews et al.   SCIENCE

Postexposure Protection of Macaques from Vaginal SHIV Infection by Topical Integrase Inhibitors

(2014) C. Dobard et al.   Science Translational Medicine

Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial

(2013) Kachit Choopanya et al.   LANCET

Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

(2013) Hasina Samji et al.   PLoS One

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

(2013) Iart Shytaj et al.   Retrovirology

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

Origins of HIV and the AIDS Pandemic

(2013) P. M. Sharp et al.   Cold Spring Harbor Perspectives in Medicine

Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

(2012) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

(2012) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

(2012) Koen K A Van Rompay et al.   Retrovirology

A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model

(2012) Iart Luca Shytaj et al.   PLoS Pathogens

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

(2011) Mark G. Lewis et al.   AIDS

The Use of Nonhuman Primate Models of HIV Infection for the Evaluation of Antiviral Strategies

(2011) Koen K.A. Van Rompay   AIDS RESEARCH AND HUMAN RETROVIRUSES

Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine

(2011) H. Qureshi et al.   JOURNAL OF VIROLOGY

The TRIM5 Gene Modulates Penile Mucosal Acquisition of Simian Immunodeficiency Virus in Rhesus Monkeys

(2011) W. W. Yeh et al.   JOURNAL OF VIROLOGY

Durable Protection from Vaginal Simian-Human Immunodeficiency Virus Infection in Macaques by Tenofovir Gel and Its Relationship to Drug Levels in Tissue

(2011) C. Dobard et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complexity Surrounds HIV Prevention Advances

(2011) J. Cohen   SCIENCE

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

(2011) N. L. Letvin et al.   Science Translational Medicine

Immunology and the elusive AIDS vaccine

(2010) Herbert W. Virgin et al.   NATURE

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

(2010) Robert M. Grant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

(2010) So-Yon Lim et al.   PLoS Genetics

TRIM5α Modulates Immunodeficiency Virus Control in Rhesus Monkeys

(2010) So-Yon Lim et al.   PLoS Pathogens

Where the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts

(2010) Ivona Pandrea et al.   Current HIV/AIDS Reports

Lessons Learned from the Natural Hosts of HIV-Related Viruses

(2009) Mirko Paiardini et al.   Annual Review of Medicine

Evaluation of antiretrovirals in animal models of HIV infection

(2009) Koen K.A. Van Rompay   ANTIVIRAL RESEARCH

Microbicides and HIV prevention: lessons from the past, looking to the future

(2009) Georgina C Morris et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Update on animal models for HIV research

(2009) Nancy L. Haigwood   EUROPEAN JOURNAL OF IMMUNOLOGY

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1

(2009) Brandon F. Keele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complete Protection from Repeated Vaginal Simian-Human Immunodeficiency Virus Exposures in Macaques by a Topical Gel Containing Tenofovir Alone or with Emtricitabine

(2009) U. M. Parikh et al.   JOURNAL OF VIROLOGY

Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies

(2009) Marie-Claude Boily et al.   LANCET INFECTIOUS DISEASES

Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys

(2009) Lucie Durand-Gasselin et al.   MOLECULAR PHARMACEUTICS

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

(2009) Brandon F. Keele et al.   NATURE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV pathogenesis: 25 years of progress and persistent challenges

(2008) Jay A Levy   AIDS

Chronic Administration of Tenofovir to Rhesus Macaques from Infancy through Adulthood and Pregnancy: Summary of Pharmacokinetics and Biological and Virological Effects

(2008) K. K. A. Van Rompay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral CD8+T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6

(2008) M. Genescà et al.   JOURNAL OF INTERNAL MEDICINE

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission

(2008) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whither or Wither Microbicides?

(2008) R. M. Grant et al.   SCIENCE

Microbicide safety/efficacy studies in animals: macaques and small animal models

(2008) Ronald S Veazey   Current Opinion in HIV and AIDS

The Use of Nonhuman Primate Models in HIV Vaccine Development

(2008) Cecilia Morgan et al.   PLOS MEDICINE