Natural SIV Hosts: Showing AIDS the Door

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques

(2014) J. D. Estes et al.   JOURNAL OF IMMUNOLOGY

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells

(2011) Jeffrey M. Milush et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of CD4+ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

(2011) Alexandra M. Ortiz et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

(2011) Margalida Rotger et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary Infection

(2011) M. Meythaler et al.   JOURNAL OF IMMUNOLOGY

Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)

(2011) C. Apetrei et al.   JOURNAL OF VIROLOGY

Mother-to-Infant Transmission of Simian Immunodeficiency Virus Is Rare in Sooty Mangabeys and Is Associated with Low Viremia

(2011) A. Chahroudi et al.   JOURNAL OF VIROLOGY

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

In brief

(2011)   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections

(2010) Jason M. Brenchley et al.   IMMUNITY

Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys Is Not Associated with High Levels of Autologous Neutralizing Antibodies

(2010) B. Li et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Island Biogeography Reveals the Deep History of SIV

(2010) M. Worobey et al.   SCIENCE

A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

(2010) Nadeene E. Riddick et al.   PLoS Pathogens

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Immune activation and AIDS pathogenesis

(2009) Donald L Sodora et al.   AIDS

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

(2009) Steven E. Bosinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

(2009) Brandon F. Keele et al.   NATURE

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

(2009) Coreen M Beaumier et al.   NATURE MEDICINE

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

(2009) Donald L Sodora et al.   NATURE MEDICINE

Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa

(2009) A. D. Redd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization

(2009) Sharon Lederer et al.   PLoS Pathogens

Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis

(2008) M. Paiardini et al.   BLOOD

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys

(2008) Nichole R. Klatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Paucity of CD4+ CCR5+ T Cells May Prevent Transmission of Simian Immunodeficiency Virus in Natural Nonhuman Primate Hosts by Breast-Feeding

(2008) I. Pandrea et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys

(2008) I. Pandrea et al.   JOURNAL OF VIROLOGY

Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis

(2008) S. N. Gordon et al.   JOURNAL OF VIROLOGY