New Paradigms for HIV/AIDS Vaccine Development

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

(2011) Morgane Bomsel et al.   IMMUNITY

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibody-Dependent Cell-Mediated Viral Inhibition Emerges after Simian Immunodeficiency Virus SIVmac251 Infection of Rhesus Monkeys Coincident with gp140-Binding Antibodies and Is Effective against Neutralization-Resistant Viruses

(2011) M. Asmal et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial

(2011) Morgane Rolland et al.   NATURE MEDICINE

HIV-1 Vaccines and Adaptive Trial Designs

(2011) L. Corey et al.   Science Translational Medicine

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

(2011) N. L. Letvin et al.   Science Translational Medicine

The Role of Antibodies in HIV Vaccines

(2010) John R. Mascola et al.   Annual Review of Immunology

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination

(2010) M. Juliana McElrath et al.   IMMUNITY

Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections

(2010) Jason M. Brenchley et al.   IMMUNITY

Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV‐1 Infection

(2010) M. Juliana McElrath   JOURNAL OF INFECTIOUS DISEASES

Viral Evolution and Escape during Acute HIV‐1 Infection

(2010) Christian L. Boutwell et al.   JOURNAL OF INFECTIOUS DISEASES

Cross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression

(2010) Zelda Euler et al.   JOURNAL OF INFECTIOUS DISEASES

A Spread-Deficient Cytomegalovirus for Assessment of First-Target Cells in Vaccination

(2010) C. A. Mohr et al.   JOURNAL OF VIROLOGY

Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

(2010) W. L. Dinges et al.   JOURNAL OF VIROLOGY

T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge

(2010) M. A. Martins et al.   JOURNAL OF VIROLOGY

Macaques Vaccinated with Simian Immunodeficiency Virus SIVmac239 nef Delay Acquisition and Control Replication after Repeated Low-Dose Heterologous SIV Challenge

(2010) M. R. Reynolds et al.   JOURNAL OF VIROLOGY

Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus

(2010) S. G. Hansen et al.   SCIENCE

HIV vaccines: lessons learned and the way forward

(2010) Jerome H Kim et al.   Current Opinion in HIV and AIDS

Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

(2010) Glenda Gray et al.   Current Opinion in HIV and AIDS

Toward an Antibody-Based HIV-1 Vaccine

(2009) James A. Hoxie   Annual Review of Medicine

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

(2009) Nilu Goonetilleke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vaccine-Induced, Simian Immunodeficiency Virus-Specific CD8+ T Cells Reduce Virus Replication but Do Not Protect from Simian Immunodeficiency Virus Disease Progression

(2009) J. C. Engram et al.   JOURNAL OF IMMUNOLOGY

Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines

(2009) R. H. Florese et al.   JOURNAL OF IMMUNOLOGY

Protective Efficacy of a Single Immunization of a Chimeric Adenovirus Vector-Based Vaccine against Simian Immunodeficiency Virus Challenge in Rhesus Monkeys

(2009) D. H. Barouch et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection: an IgA gene and functional analysis

(2009) D Tudor et al.   Mucosal Immunology

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

(2009) Ann J Hessell et al.   NATURE MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

(2009) Bin Jia et al.   PLoS Pathogens

HIV infection of the genital mucosa in women

(2009) Florian Hladik et al.   Current HIV/AIDS Reports

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

(2008) Matthew R. Reynolds et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antiviral CD8+T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6

(2008) M. Genescà et al.   JOURNAL OF INTERNAL MEDICINE

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Rhesus CMV: an emerging animal model for human CMV

(2008) Colin Powers et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

(2008) Jinyan Liu et al.   NATURE

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans

(2008) David I Watkins et al.   NATURE MEDICINE

Toward an AIDS Vaccine

(2008) B. D. Walker et al.   SCIENCE

Relevance of studying T cell responses in SIV-infected rhesus macaques

(2008) Laura E. Valentine et al.   TRENDS IN MICROBIOLOGY

Pathogenic mechanisms in simian immunodeficiency virus infection

(2008) Zvi Grossman et al.   Current Opinion in HIV and AIDS