ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

A Review of the Association Between Parkinson Disease and Malignant Melanoma

(2016) Max Disse et al.   DERMATOLOGIC SURGERY

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells

(2016) Jin-Gu Lee et al.   NATURE CELL BIOLOGY

Loss of ATP13A2 impairs glycolytic function in Kufor-Rakeb syndrome patient-derived cell models

(2016) Jin-Sung Park et al.   PARKINSONISM & RELATED DISORDERS

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

(2016) Carla F. Bento et al.   Nature Communications

Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma

(2016) Seyma Demirsoy et al.   Frontiers in Oncology

Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells

(2015) S. Martin et al.   BIOCHEMICAL PHARMACOLOGY

The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity

(2015) Débora E. Rinaldi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies

(2015) Hannelore Maes et al.   FEBS Journal

PI(3,5)P2controls endosomal branched actin dynamics by regulating cortactin–actin interactions

(2015) Nan Hyung Hong et al.   JOURNAL OF CELL BIOLOGY

PARKINInactivation Links Parkinson’s Disease to Melanoma

(2015) Hui-Han Hu et al.   JNCI-Journal of the National Cancer Institute

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

(2015) Diego Ploper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A lipid switch unlocks Parkinson’s disease-associated ATP13A2

(2015) Tine Holemans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperactivated endolysosomal trafficking in melanoma

(2015) Direna Alonso-Curbelo et al.   Oncotarget

RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

(2015) Direna Alonso-Curbelo et al.   Oncotarget

PARKINInactivation Links Parkinson’s Disease to Melanoma

(2015) Hui-Han Hu et al.   JNCI-Journal of the National Cancer Institute

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

(2014) Direna Alonso-Curbelo et al.   CANCER CELL

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Roles for PI(3,5)P2 in nutrient sensing through TORC1

(2014) Natsuko Jin et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

(2014) Sarah van Veen et al.   Frontiers in Molecular Neuroscience

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells

(2014) Eun-Jin Bae et al.   Experimental Neurobiology

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

(2013) Amber J. McCartney et al.   BIOESSAYS

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

(2013) Hideaki Matsui et al.   FEBS LETTERS

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

(2013) Taiji Tsunemi et al.   HUMAN MOLECULAR GENETICS

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Lysosomal dysfunction in neurodegeneration

(2012) Marija Usenovic et al.   Autophagy

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

(2012) Marija Usenovic et al.   HUMAN MOLECULAR GENETICS

Malignant melanoma, breast cancer and other cancers in patients with Parkinson's disease

(2012) Kathrine Rugbjerg et al.   INTERNATIONAL JOURNAL OF CANCER

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants

(2012) Jason P. Covy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese

(2012) Gerda Rentschler et al.   NEUROTOXICOLOGY

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism

(2012) Agata Podhajska et al.   PLoS One

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death

(2011) Janet Ugolino et al.   HUMAN MOLECULAR GENETICS

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

(2011) Jin-Sung Park et al.   HUMAN MUTATION

Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein

(2011) Jieqiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Meta-analysis of the relationship between Parkinson disease and melanoma

(2011) R. Liu et al.   NEUROLOGY

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Juvenile dystonia-parkinsonism and dementia caused by a novel ATP13A2 frameshift mutation

(2010) David Crosiers et al.   PARKINSONISM & RELATED DISORDERS

COP9-Associated CSN5 Regulates Exosomal Protein Deubiquitination and Sorting

(2009) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Quality control of the proteins associated with neurodegenerative diseases

(2008) Xuechao Gao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA