Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

Yunis-Varón Syndrome Is Caused by Mutations in FIG4, Encoding a Phosphoinositide Phosphatase

(2013) Philippe M. Campeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching

(2013) Ognian C. Ikonomov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Vac14 Protein Multimerization Is a Prerequisite Step for Fab1 Protein Complex Assembly and Function

(2013) Tamadher A. Alghamdi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Structural Changes and Acidification of Guard Cell Vacuoles during Stomatal Closure Require Phosphatidylinositol 3,5-Bisphosphate

(2013) G. Bak et al.   PLANT CELL

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

(2013) S. Takasuga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

(2013) E. E. Er et al.   Science Signaling

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

(2012) Diego Sbrissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2and PI(5)P

(2012) Yanling Zhang et al.   EMBO JOURNAL

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

(2012) Angela Oppelt et al.   EMBO REPORTS

PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation

(2012) David R. Jones et al.   FASEB JOURNAL

Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics

(2012) Kaoru Hazeki et al.   FEBS LETTERS

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration

(2012) C. J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18

(2012) Yasunori Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class II formin targeting to the cell cortex by binding PI(3,5)P2is essential for polarized growth

(2012) Peter A.C. van Gisbergen et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

(2012) Dave Bridges et al.   MOLECULAR BIOLOGY OF THE CELL

Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements

(2012) Martin Zieger et al.   MOLECULAR BIOLOGY OF THE CELL

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

(2012) Sulochanadevi Baskaran et al.   MOLECULAR CELL

Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling

(2012) Guiscard Seebohm et al.   PLoS One

Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

(2012) Roswitha Krick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fig4 deficiency: A newly emerged lysosomal storage disorder?

(2012) Colin Martyn et al.   PROGRESS IN NEUROBIOLOGY

Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction

(2011) Neerupma Silswal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Distinct pathogenic processes between Fig4-deficient motor and sensory neurons

(2011) Istvan Katona et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1

(2011) B.-K. Han et al.   GENES & DEVELOPMENT

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fig4 Expression in the Rodent Nervous System and Its Potential Role in Preventing Abnormal Lysosomal Accumulation

(2011) Jiasong Guo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Congenital CNS Hypomyelination in the Fig4 Null Mouse Is Rescued by Neuronal Expression of the PI(3,5)P2 Phosphatase Fig4

(2011) J. J. Winters et al.   JOURNAL OF NEUROSCIENCE

Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice

(2011) Qing Yan et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2

(2011) Cheuk Y. Ho et al.   TRAFFIC

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

(2011) Guy M. Lenk et al.   PLoS Genetics

Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies

(2011) Ilaria Vaccari et al.   PLoS Genetics

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

(2010) Andrew Manford et al.   EMBO JOURNAL

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

ArPIKfyve Regulates Sac3 Protein Abundance and Turnover

(2010) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility via Activation of the Ryanodine Receptor

(2010) Chad D. Touchberry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins

(2010) Björn H. Falkenburger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss-of-Function and Gain-of-Function Mutations in FAB1A/B Impair Endomembrane Homeostasis, Conferring Pleiotropic Developmental Abnormalities in Arabidopsis

(2010) T. Hirano et al.   PLANT PHYSIOLOGY

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

(2009) Ognian C. Ikonomov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

Changing phosphoinositides “on the fly”: how trafficking vesicles avoid an identity crisis

(2009) Roberto J. Botelho   BIOESSAYS

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

PIKfyve-ArPIKfyve-Sac3 Core Complex

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Clavesin Family, Neuron-specific Lipid- and Clathrin-binding Sec14 Proteins Regulating Lysosomal Morphology

(2009) Yohei Katoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death

(2009) Fuminori Tsuruta et al.   JOURNAL OF CELL BIOLOGY

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis

(2009) Jinhua Shen et al.   NATURE CELL BIOLOGY

Arabidopsis FAB1/PIKfyve Proteins Are Essential for Development of Viable Pollen

(2009) P. Whitley et al.   PLANT PHYSIOLOGY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration

(2008) Xuebao Zhang et al.   BRAIN

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

(2008) Natsuko Jin et al.   EMBO JOURNAL

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin

(2008) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality

(2008) Diego Sbrissa et al.   JOURNAL OF MOLECULAR BIOLOGY

Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase

(2008) Roberto J. Botelho et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY