Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation

(2016) Matthias Waldner et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Gene editing technology as an approach to the treatment of liver diseases

(2016) Rajagopal N. Aravalli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

(2016) Benjamin L. Farah et al.   JOURNAL OF HEPATOLOGY

Targeting adeno-associated virus and adenoviral gene therapy for hepatocellular carcinoma

(2016) Yi-Gang Wang   WORLD JOURNAL OF GASTROENTEROLOGY

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

(2015) Sujuan Guo et al.   Autophagy

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg

(2015) M. Biswas et al.   BLOOD

Engineering the AAV capsid to optimize vector–host-interactions

(2015) Hildegard Büning et al.   CURRENT OPINION IN PHARMACOLOGY

New and improved AAVenues: current status of hemophilia B gene therapy

(2015) Mark A Brimble et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction

(2015) Garrett E. Berry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of Anti-Adeno-Associated Virus Vector Neutralizing Antibody Titer with anIn VitroReporter System

(2015) Amine Meliani et al.   Human Gene Therapy Methods

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transductionin vitroandin vivo

(2014) Marianna Hösel et al.   HEPATOLOGY

Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B

(2014) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer

(2013) Valerie Nelson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle

(2013) Takako Naito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Divergent Roles of Autophagy in Virus Infection

(2013) Abhilash Chiramel et al.   Cells

A novel image-based cytometry method for autophagy detection in living cells

(2012) Leo Li-Ying Chan et al.   Autophagy

Intracellular transport of recombinant adeno-associated virus vectors

(2012) M Nonnenmacher et al.   GENE THERAPY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?

(2011) Luc JW van der Laan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors

(2011) Marianna Hösel et al.   HEPATOLOGY

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

(2010) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient expression of genes delivered to newborn rat liver using recombinant adeno-associated virus 2/8 vectors

(2009) Maude Flageul et al.   JOURNAL OF GENE MEDICINE

Enhancing transduction of the liver by adeno-associated viral vectors

(2008) A C Nathwani et al.   GENE THERAPY