Intracellular transport of recombinant adeno-associated virus vectors

Adeno-Associated Virus 2 Infection Requires Endocytosis through the CLIC/GEEC Pathway

(2011) Mathieu Nonnenmacher et al.   Cell Host & Microbe

Unique Characteristics of AAV1, 2, and 5 Viral Entry, Intracellular Trafficking, and Nuclear Import Define Transduction Efficiency in HeLa Cells

(2011) Nicholas W. Keiser et al.   HUMAN GENE THERAPY

Structural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal Trafficking

(2011) H.-J. Nam et al.   JOURNAL OF VIROLOGY

Enhancers of Adeno-associated Virus AAV2 Transduction via High Throughput siRNA Screening

(2011) Alexis J Wallen et al.   MOLECULAR THERAPY

AAV Exploits Subcellular Stress Associated with Inflammation, Endoplasmic Reticulum Expansion, and Misfolded Proteins in Models of Cystic Fibrosis

(2011) Jarrod S. Johnson et al.   PLoS Pathogens

Comparative Cardiac Gene Delivery of Adeno-Associated Virus Serotypes 1-9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart

(2010) Carmela Zincarelli et al.   CTS-Clinical and Translational Science

Update on non-viral delivery methods for cancer therapy: possibilities of a drug delivery system with anticancer activities beyond delivery as a new therapeutic tool

(2010) Yasufumi Kaneda   Expert Opinion on Drug Delivery

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors

(2010) N Zeltner et al.   GENE THERAPY

High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy

(2010) Mengxin Li et al.   HUMAN GENE THERAPY

Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle

(2010) Chunping Qiao et al.   HUMAN GENE THERAPY

Enhanced Long-Term Transduction and Multilineage Engraftment of Human Hematopoietic Stem Cells Transduced with Tyrosine-Modified Recombinant Adeno-Associated Virus Serotype 2

(2010) M. Ariel Kauss et al.   HUMAN GENE THERAPY

Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype 3

(2010) Chen Ling et al.   HUMAN GENE THERAPY

Mutagenesis of Adeno-Associated Virus Type 2 Capsid Protein VP1 Uncovers New Roles for Basic Amino Acids in Trafficking and Cell-Specific Transduction

(2010) J. S. Johnson et al.   JOURNAL OF VIROLOGY

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6

(2010) R. Ng et al.   JOURNAL OF VIROLOGY

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

(2010) David M Markusic et al.   MOLECULAR THERAPY

Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina

(2010) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

(2010) Melodie L Weller et al.   NATURE MEDICINE

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

BAAV Transcytosis Requires an Interaction with β-1-4 Linked- Glucosamine and gp96

(2010) Giovanni Di Pasquale et al.   PLoS One

Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

(2010) A. Wittrup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A viral assembly factor promotes AAV2 capsid formation in the nucleolus

(2010) F. Sonntag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles

(2010) Stefanie Stahnke et al.   VIROLOGY

Virus entry paradigms

(2009) Manjula Kalia et al.   AMINO ACIDS

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Optimized Adeno-Associated Virus (AAV)–Protein Phosphatase-5 Helper Viruses for Efficient Liver Transduction by Single-Stranded AAV Vectors: Therapeutic Expression of Factor IX at Reduced Vector Doses

(2009) Giridhara R. Jayandharan et al.   HUMAN GENE THERAPY

Adeno-associated virus type 5 exploits two different entry pathways in human embryo fibroblasts

(2009) U. Bantel-Schaal et al.   JOURNAL OF GENERAL VIROLOGY

E4orf1 Limits the Oncolytic Potential of the E1B-55K Deletion Mutant Adenovirus

(2009) M. A. Thomas et al.   JOURNAL OF VIROLOGY

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

(2009) Albert M Maguire et al.   LANCET

AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells

(2009) Lyudmyla G. Glushakova et al.   MOLECULAR GENETICS AND METABOLISM

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

(2009) Francesca Simonelli et al.   MOLECULAR THERAPY

Doxorubicin augments rAAV-2 transduction in rat neuronal cells

(2009) Ting Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Gene Therapy Fulfilling Its Promise

(2009) Donald B. Kohn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tracing the Retrograde Route in Protein Trafficking

(2008) Ludger Johannes et al.   CELL

Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo

(2008) G R Jayandharan et al.   GENE THERAPY

Novel AAV serotypes for improved ocular gene transfer

(2008) Corinna Lebherz et al.   JOURNAL OF GENE MEDICINE

Heparin binding induces conformational changes in Adeno-associated virus serotype 2

(2008) Hazel C. Levy et al.   JOURNAL OF STRUCTURAL BIOLOGY

Enhancement of Adeno-Associated Virus Infection by Mobilizing Capsids into and Out of the Nucleolus

(2008) J. S. Johnson et al.   JOURNAL OF VIROLOGY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

(2008) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

(2008) L. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

(2008) Li Zhong et al.   VIROLOGY