Targeting adeno-associated virus and adenoviral gene therapy for hepatocellular carcinoma

Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

(2015) Jessica Lo et al.   HEPATOLOGY

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

(2015) Randy J. Chandler et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-directed gene therapy of chronic hepadnavirus infection using interferon alpha tethered to apolipoprotein A-I

(2015) Pedro Berraondo et al.   JOURNAL OF HEPATOLOGY

Adeno-Associated Virus-Mediated MicroRNA Delivery and Therapeutics

(2015) Jun Xie et al.   SEMINARS IN LIVER DISEASE

Targeting Gene-Virus-Mediated Manganese Superoxide Dismutase Effectively Suppresses Tumor Growth in Hepatocellular Carcinoma In Vitro and In Vivo

(2014) Fang Huang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers

(2014) T Du et al.   CANCER GENE THERAPY

Prognosis of untreated hepatocellular carcinoma

(2014) Edoardo G. Giannini et al.   HEPATOLOGY

Selective In Vivo Targeting of Human Liver Tumors by Optimized AAV3 Vectors in a Murine Xenograft Model

(2014) Chen Ling et al.   HUMAN GENE THERAPY

Synergistic suppression effect on tumor growth of hepatocellular carcinoma by combining oncolytic adenovirus carrying XAF1 with cisplatin

(2014) Buyun Ma et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Adeno-Associated Virus Vectors and Neurological Gene Therapy

(2014) David S. Ojala et al.   NEUROSCIENTIST

Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

(2014) Li Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials

(2014) Bruna Scaggiante   WORLD JOURNAL OF GASTROENTEROLOGY

SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC

(2014) Qiang Pan et al.   Human Cell

Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside

(2014) Valerie Ferreira et al.   Frontiers in Immunology

Trial Watch:

(2014) Jonathan Pol et al.   OncoImmunology

Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model

(2013) Wen Lei et al.   ACTA PHARMACOLOGICA SINICA

Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo

(2013) Liujiang Song et al.   CYTOTHERAPY

Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy

(2013) Jheel Pandya et al.   IMMUNOLOGY AND CELL BIOLOGY

Systemic Image-Guided Liver Cancer Radiovirotherapy Using Dendrimer-Coated Adenovirus Encoding the Sodium Iodide Symporter as Theranostic Gene

(2013) G. K. Grunwald et al.   JOURNAL OF NUCLEAR MEDICINE

Adenovirus-Based Vaccine with Epitopes Incorporated in Novel Fiber Sites to Induce Protective Immunity against Pseudomonas aeruginosa

(2013) Anurag Sharma et al.   PLoS One

Cancer Immunotherapy

(2013) M. McNutt   SCIENCE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma

(2013) Lijie Yuan et al.   TUMOR BIOLOGY

Prospects for oral replicating adenovirus-vectored vaccines

(2013) Cailin Deal et al.   VACCINE

Safety profile of recombinant adeno-associated viral vectors: focus on alipogene tiparvovec (Glybera®)

(2013) Florence Salmon et al.   Expert Review of Clinical Pharmacology

Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta- analysis

(2012) Ying Zhou et al.   BMC CANCER

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

(2012) I. Diaconu et al.   CANCER RESEARCH

Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth

(2012) Guoqing He et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Polymer coatings for delivery of nucleic acid therapeutics

(2012) Richard Laga et al.   JOURNAL OF CONTROLLED RELEASE

An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

(2012) Vincenzo Cerullo et al.   MOLECULAR THERAPY

Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL

(2011) X Liu et al.   CANCER GENE THERAPY

AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?

(2011) Luc JW van der Laan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene

(2011) X Cao et al.   GENE THERAPY

Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

(2011) J D Dias et al.   GENE THERAPY

Augmenting the Antitumor Effect of TRAIL by SOCS3 with Double-Regulated Replicating Oncolytic Adenovirus in Hepatocellular Carcinoma

(2011) Rui-Cheng Wei et al.   HUMAN GENE THERAPY

Conformational Changes in Adeno-Associated Virus Type 1 Induced by Genome Packaging

(2011) Britta Gerlach et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent deal highlights hopes for cancer-killing viruses

(2011) Jon Evans   NATURE MEDICINE

Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells

(2011) Huajun Jin et al.   PLoS One

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors

(2011) Chen Ling et al.   Jove-Journal of Visualized Experiments

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

(2010) Vincenzo Cerullo et al.   CANCER RESEARCH

Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma

(2010) Yilei Mao et al.   GUT

The efficacy of combination therapy using adeno-associated virus-TRAIL targeting to telomerase activity and cisplatin in a mice model of hepatocellular carcinoma

(2010) Yigang Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Systematic review of hepatocellular adenoma in China and other regions

(2010) Haoming Lin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24

(2009) Yu-mei Wu et al.   ACTA PHARMACOLOGICA SINICA

Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-β expression driven by hTERT promoter

(2009) Ling Feng He et al.   CANCER LETTERS

Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer

(2009) De Bin Yu et al.   CANCER SCIENCE

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus

(2009) Kang Jian Zhang et al.   HUMAN GENE THERAPY

Antisense Hypoxia-Inducible Factor-1α Augments Transcatheter Arterial Embolization in the Treatment of Hepatocellular Carcinomas in Rats

(2009) Xueying Sun et al.   HUMAN GENE THERAPY

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

(2009) Albert M Maguire et al.   LANCET

Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration

(2008) Karen J. Ho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma

(2008) Zan Shen et al.   CANCER LETTERS

Oncolytic adenovirus-mediated shRNA against Apollon inhibits tumor cell growth and enhances antitumor effect of 5-fluorouracil

(2008) L Chu et al.   GENE THERAPY

Adeno-associated virus integration: virus versus vector

(2008) R H Smith   GENE THERAPY

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Significant antitumor activity of oncolytic adenovirus expressing human interferon-β for hepatocellular carcinoma

(2008) Ling Feng He et al.   JOURNAL OF GENE MEDICINE

Potent antitumor effect of TRAIL mediated by a novel adeno-associated viral vector targeting to telomerase activity for human hepatocellular carcinoma

(2008) Yigang Wang et al.   JOURNAL OF GENE MEDICINE

Adeno-associated virus-mediated expression of kallistatin suppresses local and remote hepatocellular carcinomas

(2008) Lai Yin Tse et al.   JOURNAL OF GENE MEDICINE

AAV-mediated TRAIL gene expression driven by hTERT promoter suppressed human hepatocellular carcinoma growth in mice

(2008) Ying Zhang et al.   LIFE SCIENCES

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic antitumor activity of XIAP-shRNA and TRAIL expressed by oncolytic adenoviruses in experimental HCC

(2007) Qiuwei Pan et al.   ACTA ONCOLOGICA