Gene-nutrient interactions and susceptibility to human obesity

Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis

(2016) Guanlin Wang et al.   Cell Metabolism

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

(2016) M. Pigeyre et al.   CLINICAL SCIENCE

Testing the role of predicted gene knockouts in human anthropometric trait variation

(2016) Samuel Lessard et al.   HUMAN MOLECULAR GENETICS

A thrifty variant in CREBRF strongly influences body mass index in Samoans

(2016) Ryan L Minster et al.   NATURE GENETICS

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children

(2016) Arkan Abadi et al.   Obesity

Exposing the exposures responsible for type 2 diabetes and obesity

(2016) P. W. Franks et al.   SCIENCE

A Novel Approach to the Nutrigenetics and Nutrigenomics of Obesity and Weight Management

(2016) Yael T. Joffe et al.   Current Oncology Reports

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

(2016) Hudson Reddon et al.   Scientific Reports

Pacific Populations, Metabolic Disease and ‘Just-So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania

(2015) Anna L. Gosling et al.   ANNALS OF HUMAN GENETICS

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

(2015) Shafqat Ahmad et al.   BMC Medical Genetics

The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction

(2015) David Jelinek et al.   GENE

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

(2015) Jennifer A. Nettleton et al.   HUMAN MOLECULAR GENETICS

Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity

(2015) Sara Hägg et al.   HUMAN MOLECULAR GENETICS

Gene–environment interactions in obesity: implication for future applications in preventive medicine

(2015) Sho Nakamura et al.   JOURNAL OF HUMAN GENETICS

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Population genetic differentiation of height and body mass index across Europe

(2015) Matthew R Robinson et al.   NATURE GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

What childhood obesity prevention programmes work? A systematic review and meta-analysis

(2015) Y. Wang et al.   Obesity Reviews

Behavioral susceptibility to obesity: Gene–environment interplay in the development of weight

(2015) Clare Llewellyn et al.   PHYSIOLOGY & BEHAVIOR

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

(2014) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The spatial clustering of obesity: does the built environment matter?

(2014) R. Huang et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies

(2014) Q. Qi et al.   BMJ-British Medical Journal

Evolutionary Perspectives on the Obesity Epidemic: Adaptive, Maladaptive, and Neutral Viewpoints

(2013) John R. Speakman   Annual Review of Nutrition

Tackling overweight and obesity: does the public health message match the science?

(2013) Katherine Hafekost et al.   BMC Medicine

MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation

(2013) L. Bian et al.   HUMAN MOLECULAR GENETICS

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis

(2013) C H Llewellyn et al.   INTERNATIONAL JOURNAL OF OBESITY

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Obesity genomics: assessing the transferability of susceptibility loci across diverse populations

(2013) Yingchang Lu et al.   Genome Medicine

Prioritizing Genetic Variants for Causality on the Basis of Preferential Linkage Disequilibrium

(2012) Qianqian Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Energy Balance and Obesity

(2012) James O. Hill et al.   CIRCULATION

Gene-Diet Interactions in Childhood Obesity

(2012) William S. Garver   CURRENT GENOMICS

Genetics of Obesity: What have we Learned?

(2012) Helene Choquet et al.   CURRENT GENOMICS

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

(2011) Sean Myles et al.   BMC Medical Genetics

Genetic influences in childhood obesity: recent progress and recommendations for experimental designs

(2011) J R Fernandez et al.   INTERNATIONAL JOURNAL OF OBESITY

Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity

(2011) C E Smith et al.   INTERNATIONAL JOURNAL OF OBESITY

Implication of European-derived adiposity loci in African Americans

(2011) J M Hester et al.   INTERNATIONAL JOURNAL OF OBESITY

Developments in Obesity Genetics in the Era of Genome-Wide Association Studies

(2011) Felix R. Day et al.   Journal of Nutrigenetics and Nutrigenomics

A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI

(2011) Dolores Corella et al.   JOURNAL OF NUTRITION

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

(2011) Tuomas O Kilpeläinen et al.   NATURE GENETICS

Dietary Saturated Fat Intake Is Negatively Associated With Weight Maintenance Among the PREMIER Participants

(2011) Pao-Hwa Lin et al.   Obesity

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

(2011) Carl A. Anderson et al.   PLOS BIOLOGY

Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk

(2010) Vasanti S. Malik et al.   CIRCULATION

Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance

(2010) D. Jelinek et al.   HUMAN MOLECULAR GENETICS

Synthetic associations in the context of genome-wide association scan signals

(2010) G. Orozco et al.   HUMAN MOLECULAR GENETICS

Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene–saturated fat interaction

(2010) D Corella et al.   INTERNATIONAL JOURNAL OF OBESITY

Hints of hidden heritability in GWAS

(2010) Greg Gibson   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

The “Thrifty Genotype” in 19981

(2010) James V. Neel   NUTRITION REVIEWS

Prevention of Overweight and Obesity: How Effective is the Current Public Health Approach

(2010) Ruth S.M. Chan et al.   International Journal of Environmental Research and Public Health

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

(2009) Florianne Bauer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

(2009) Shengxu Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Childhood obesity: are genetic differences involved?

(2009) Claude Bouchard   AMERICAN JOURNAL OF CLINICAL NUTRITION

APOA2, Dietary Fat, and Body Mass Index

(2009) Dolores Corella   ARCHIVES OF INTERNAL MEDICINE

Associations between sleeping habits and food consumption patterns among 10–11-year-old children in Finland

(2009) Lisa Westerlund et al.   BRITISH JOURNAL OF NUTRITION

Synergy of nature and nurture in the development of childhood obesity

(2009) B E Levin   INTERNATIONAL JOURNAL OF OBESITY

A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes

(2009) C Razquin et al.   INTERNATIONAL JOURNAL OF OBESITY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

A supersized list of obesity genes

(2009) Marten Hofker et al.   NATURE GENETICS

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

Decreased Npc1 Gene Dosage in Mice Is Associated With Weight Gain

(2009) David Jelinek et al.   Obesity

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation

(2008) I Aeberli et al.   INTERNATIONAL JOURNAL OF OBESITY

Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?

(2008) A M Prentice et al.   INTERNATIONAL JOURNAL OF OBESITY

Feedback models allowing estimation of thresholds for self-promoting body weight gain

(2008) Edmund Christiansen et al.   JOURNAL OF THEORETICAL BIOLOGY

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Challenges in the study of causation of obesity

(2008) Thorkild I. A. Sørensen   PROCEEDINGS OF THE NUTRITION SOCIETY

Glycemic Instability and Spontaneous Energy Intake: Association With Knowledge-Based Work

(2008) Jean-Philippe Chaput et al.   PSYCHOSOMATIC MEDICINE