Pacific Populations, Metabolic Disease and ‘Just-So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania

Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes

(2014) Qasim Ayub et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recent developments in the genetic history of East Asia and Oceania

(2014) Ana T Duggan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

On the Evolutionary Origins of Obesity: A New Hypothesis

(2014) Dyan Sellayah et al.   ENDOCRINOLOGY

From west to east: Environmental influences on the rate and pathways of Polynesian colonization

(2014) Alvaro Montenegro et al.   HOLOCENE

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

Natural selection and infectious disease in human populations

(2014) Elinor K. Karlsson et al.   NATURE REVIEWS GENETICS

Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?

(2014) Xuan-Han Koh et al.   PLoS One

Climate windows for Polynesian voyaging to New Zealand and Easter Island

(2014) I. D. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary history and metabolic insights of ancient mammalian uricases

(2014) J. T. Kratzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scurvy in a tropical paradise? Evaluating the possibility of infant and adult vitamin C deficiency in the Lapita skeletal sample of Teouma, Vanuatu, Pacific islands

(2014) Hallie R. Buckley et al.   International Journal of Paleopathology

Evolutionary Perspectives on the Obesity Epidemic: Adaptive, Maladaptive, and Neutral Viewpoints

(2013) John R. Speakman   Annual Review of Nutrition

Hyperuricaemia in the Pacific: why the elevated serum urate levels?

(2013) Anna L. Gosling et al.   RHEUMATOLOGY INTERNATIONAL

A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis

(2012) J. R. Speakman et al.   Disease Models & Mechanisms

High Precision U/Th Dating of First Polynesian Settlement

(2012) David Burley et al.   PLoS One

Implications for health and disease in the genetic signature of the Ashkenazi Jewish population

(2012) Saurav Guha et al.   GENOME BIOLOGY

Common Variants in FTO Are Not Significantly Associated with Obesity-Related Phenotypes among Samoans of Polynesia

(2011) Rebekah Karns et al.   ANNALS OF HUMAN GENETICS

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

(2011) Sean Myles et al.   BMC Medical Genetics

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia

(2011) M. Rasmussen et al.   SCIENCE

Body mass index and risk of tuberculosis and death

(2010) Colleen F Hanrahan et al.   AIDS

The Human Genetic History of Oceania: Near and Remote Views of Dispersal

(2010) Manfred Kayser   CURRENT BIOLOGY

Demographic History of Oceania Inferred from Genome-wide Data

(2010) Andreas Wollstein et al.   CURRENT BIOLOGY

The obesity paradox in community-acquired bacterial pneumonia

(2010) Vicente F. Corrales-Medina et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The “Thrifty Genotype” in 19981

(2010) James V. Neel   NUTRITION REVIEWS

High-precision radiocarbon dating shows recent and rapid initial human colonization of East Polynesia

(2010) Janet M. Wilmshurst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Adaptation and Plant Use in Highland New Guinea 49,000 to 44,000 Years Ago

(2010) G. R. Summerhayes et al.   SCIENCE

Type 2 diabetes, cardiovascular disease, and the evolutionary paradox of the polycystic ovary syndrome: A fertility first hypothesis

(2009) Stephen J. Corbett et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans

(2009) Ranjan Deka et al.   BMC Medical Genetics

Body size, body composition and fat distribution: comparative analysis of European, Maori, Pacific Island and Asian Indian adults

(2009) Elaine C. Rush et al.   BRITISH JOURNAL OF NUTRITION

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

(2009) L. Southam et al.   DIABETOLOGIA

ADAPTIONISM-30 YEARS AFTER GOULD AND LEWONTIN

(2009) Rasmus Nielsen   EVOLUTION

The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders

(2009) Takuro Furusawa et al.   HUMAN GENETICS

Susceptibility Loci for Adiposity Phenotypes on 8p, 9p, and 16q in American Samoa and Samoa

(2009) Karolina Åberg et al.   Obesity

Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae

(2009) Jennifer K. Lowe et al.   PLoS Genetics

Thrifty genes for obesity, an attractive but flawed idea and an alternative perspective: the ‘drifty gene’ hypothesis

(2008) J R Speakman   INTERNATIONAL JOURNAL OF OBESITY

Functional Consequences of the Human Leptin Receptor (LEPR) Q223R Transversion

(2008) George Stratigopoulos et al.   Obesity

The age and origin of the Pacific islands: a geological overview

(2008) V. E Neall et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Genetic Structure of Pacific Islanders

(2008) Jonathan S. Friedlaender et al.   PLoS Genetics