Developments in Obesity Genetics in the Era of Genome-Wide Association Studies

Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals

(2011) Tuomas O Kilpeläinen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women

(2011) T. Ahmad et al.   DIABETES CARE

The genetic epidemiology of melanocortin 4 receptor variants

(2011) Ruth J.F. Loos   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

(2011) Tuomas O Kilpeläinen et al.   NATURE GENETICS

Chromatin and heritability: how epigenetic studies can complement genetic approaches

(2011) Ewan Birney   TRENDS IN GENETICS

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

(2011) Ulla Sovio et al.   PLoS Genetics

Evaluation of Genetic Susceptibility Loci for Obesity in Chinese Women

(2010) Jiajun Shi et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

(2010) Xueyao Han et al.   BMC Medical Genetics

FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

(2010) Gaifen Liu et al.   BMC Medical Genetics

Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure

(2010) ChuanFeng Wang et al.   BRAIN RESEARCH

Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence: Influence of Loci Identified by Genome-Wide Association Studies

(2010) M. den Hoed et al.   DIABETES

FTO Genetic Variation and Association With Obesity in West Africans and African Americans

(2010) A. Adeyemo et al.   DIABETES

Evaluation of A2BP1 as an Obesity Gene

(2010) L. Ma et al.   DIABETES

A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population

(2010) Xiangyang Li et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice

(2010) David L. Morris et al.   ENDOCRINOLOGY

Assessment of physical activity – a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation

(2010) Janet M. Warren et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Fine mapping of the association with obesity at the FTO locus in African-derived populations

(2010) Mohamed T. Hassanein et al.   HUMAN MOLECULAR GENETICS

Genome-wide association of anthropometric traits in African- and African-derived populations

(2010) S. J. Kang et al.   HUMAN MOLECULAR GENETICS

Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort

(2010) M R Wing et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population

(2010) Chloe Y. Y. Cheung et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Implication of Genetic Variants NearNEGR1,SEC16B,TMEM18,ETV5/DGKG,GNPDA2,LIN7C/BDNF,MTCH2,BCDIN3D/FAIM2,SH2B1,FTO,MC4R, andKCTD15with Obesity and Type 2 Diabetes in 7705 Chinese

(2010) Maggie C. Y. Ng et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

(2010) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Common Variants Near Melanocortin 4 Receptor Are Associated with General and Visceral Adiposity in European- and African-American Youth

(2010) Gaifen Liu et al.   JOURNAL OF PEDIATRICS

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Epigenome: mapping in motion

(2010) Monya Baker   NATURE METHODS

Association ofFTOGene Variants With Adiposity in African-American Adolescents

(2010) Sureka Bollepalli et al.   Obesity

Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

(2010) Damien C. Croteau-Chonka et al.   Obesity

Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity

(2010) Yong-Jun Liu et al.   Obesity

Meta-analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

(2010) Yun Liu et al.   Obesity

Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in FTO in Whites and African-Americans in the ARIC Study

(2010) Jan Bressler et al.   PLoS One

Do Gene Variants Influencing Adult Adiposity Affect Birth Weight? A Population-Based Study of 24 Loci in 4,744 Danish Individuals

(2010) Ehm A. Andersson et al.   PLoS One

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study

(2010) Shengxu Li et al.   PLOS MEDICINE

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

(2009) Shengxu Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents’ Individual Lives Survey) Study

(2009) Eryn T Liem et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

(2009) Karani S Vimaleswaran et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity

(2009) Emily Sonestedt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

FTOgene variation and measures of body mass in an African population

(2009) Branwen J Hennig et al.   BMC Medical Genetics

Depression and body mass index, a u-shaped association

(2009) Leonore M de Wit et al.   BMC PUBLIC HEALTH

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

(2009) A. Jonsson et al.   DIABETOLOGIA

Life course variations in the associations between FTO and MC4R gene variants and body size

(2009) R. Hardy et al.   HUMAN MOLECULAR GENETICS

Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study

(2009) Y Tabara et al.   INTERNATIONAL JOURNAL OF OBESITY

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

(2009) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

(2009) Stéphane Cauchi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances

(2009) T. LaFramboise   NUCLEIC ACIDS RESEARCH

The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI

(2009) Jianhua Zhao et al.   Obesity

Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs

(2009) Latonya F. Been et al.   Obesity

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

(2009) Nancy L. Heard-Costa et al.   PLoS Genetics

Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity

(2008) Evadnie Rampersaud et al.   ARCHIVES OF INTERNAL MEDICINE

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk

(2008) Dharambir K Sanghera et al.   BMC Medical Genetics

Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

(2008) Y.-C. Chang et al.   DIABETES

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

(2008) M. C.Y. Ng et al.   DIABETES

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

(2008) J. T. Tan et al.   DIABETES

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians

(2008) C. S. Yajnik et al.   DIABETOLOGIA

Variation in the FTO Gene Influences Food Intake but not Energy Expenditure

(2008) A. Haupt et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study

(2008) T Jess et al.   INTERNATIONAL JOURNAL OF OBESITY

The FTO gene and measured food intake in children

(2008) J Wardle et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity Associated Genetic Variation inFTOIs Associated with Diminished Satiety

(2008) Jane Wardle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Variations in the FTO gene are associated with severe obesity in the Japanese

(2008) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

(2008) Joanne E. Cecil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing Heritability of BMI and Stronger Associations With the FTO Gene Over Childhood

(2008) Claire M.A. Haworth et al.   Obesity

Polymorphisms of theFTOGene Are Associated With Variation in Energy Intake, but not Energy Expenditure

(2008) John R. Speakman et al.   Obesity

Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic

(2008) Youfa Wang et al.   Obesity

Replication of Genetic Effects ofFTOPolymorphisms on BMI in a Korean Population

(2008) Seong W. Cha et al.   Obesity

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One