Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

(2017) Silvan R. Urfer et al.   GeroScience

Obesity and related consequences to ageing

(2016) Magdalena Jura et al.   AGE

Feast and famine: Adipose tissue adaptations for healthy aging

(2016) Daniele Lettieri Barbato et al.   AGEING RESEARCH REVIEWS

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

(2016) Amiya Kumar Ghosh et al.   Aging-US

Signaling Networks Determining Life Span

(2016) Celine E. Riera et al.   Annual Review of Biochemistry

Ageing with elegans: a research proposal to map healthspan pathways

(2016) Walter Luyten et al.   BIOGERONTOLOGY

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart FailureNovelty and Significance

(2016) Valentina Parisi et al.   CIRCULATION RESEARCH

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

(2016) Allyson K. Palmer et al.   EXPERIMENTAL GERONTOLOGY

Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity

(2016) N Slutsky et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Association of Sarcopenia and Obesity With Multimorbidity in Korean Adults: A Nationwide Cross-Sectional Study

(2016) Keun Ok An et al.   Journal of the American Medical Directors Association

Insulin-like growth factor-1 deficiency and metabolic syndrome

(2016) G. A. Aguirre et al.   Journal of Translational Medicine

Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

(2016) Elena Maneschi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Will calorie restriction work in humans?

(2016) Edda Cava et al.   Aging-US

Mitochondrial Hormesis links nutrient restriction to improved metabolism in fat cell

(2015) Daniele Lettieri Barbato et al.   Aging-US

Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

(2015) Yulia Haim et al.   Autophagy

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity

(2015) Hedi Soussi et al.   DIABETES

The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells

(2015) Annalisa Natalicchio et al.   DIABETOLOGIA

p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

(2015) Stefano Ciciliot et al.   DIABETOLOGIA

Adipose tissue and metabolic syndrome: too much, too little or neither

(2015) Scott M. Grundy   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

(2015) S Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Chemerin-induced mitochondrial dysfunction in skeletal muscle

(2015) Qihai Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolically normal obese people are protected from adverse effects following weight gain

(2015) Elisa Fabbrini et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology

(2015) Andrea Armani et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ageing, metabolism and cardiovascular disease

(2015) Sarah Costantino et al.   JOURNAL OF PHYSIOLOGY-LONDON

The sexual dimorphism of obesity

(2015) Biff F. Palmer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men

(2015) Iva Miljkovic et al.   Obesity

Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity

(2015) S. Goya Wannamethee et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease

(2015) Abdulmaged M. Traish et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Role of ultrasound in the diagnosis and treatment of nonalcoholic fatty liver disease and its complications

(2015) Stefano Ballestri et al.   Expert Review of Gastroenterology & Hepatology

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

(2015) Francesca Bonomini et al.   Aging and Disease

p66Shc-induced redox changes drive endothelial insulin resistance

(2014) Francesco Paneni et al.   ATHEROSCLEROSIS

Molecular regulation of autophagy and its implications for metabolic diseases

(2014) Stefan W. Ryter et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

The role of estrogen in adipose tissue metabolism: insights into glucose homeostasis regulation [Review]

(2014) Jun Ho Kim et al.   ENDOCRINE JOURNAL

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

Mechanisms of Aging-Related Impairment of Brown Adipocyte Development and Function

(2014) Antonia Graja et al.   GERONTOLOGY

Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span

(2014) C. B. Newgard et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

(2014) HUAN GONG et al.   Molecular Medicine Reports

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

(2014) S. O'Neill et al.   Obesity Reviews

Metabolic Syndrome, Sarcopenia and Role of Sex and Age: Cross-Sectional Analysis of Kashiwa Cohort Study

(2014) Shinya Ishii et al.   PLoS One

Role of forkhead box protein A3 in age-associated metabolic decline

(2014) Xinran Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mineralocorticoid receptor in adipocytes and macrophages: A promising target to fight metabolic syndrome

(2014) Vincenzo Marzolla et al.   STEROIDS

Estrogen Deficiency and the Origin of Obesity during Menopause

(2014) Fernando Lizcano et al.   Biomed Research International

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

(2013) Chongben Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Growth hormone in the aging male

(2013) Fred R. Sattler   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Beyond the Sympathetic Tone: The New Brown Fat Activators

(2013) Francesc Villarroya et al.   Cell Metabolism

Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

(2013) Mei Dong et al.   Cell Metabolism

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development

(2013) Nuria Martinez-Lopez et al.   EMBO REPORTS

The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

(2013) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

Increased cGMP promotes healthy expansion and browning of white adipose tissue

(2013) Michaela M. Mitschke et al.   FASEB JOURNAL

Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans

(2013) M Matsushita et al.   INTERNATIONAL JOURNAL OF OBESITY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of mineralocorticoid receptor and renin–angiotensin–aldosterone system in adipocyte dysfunction and obesity

(2013) Alessandra Feraco et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Influence of Shc Proteins on Life Span in Mice

(2013) Jon J. Ramsey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Aging-Associated Reductions in Lipolytic and Mitochondrial Proteins in Mouse Adipose Tissue Are Not Rescued by Metformin Treatment

(2013) E. Mennes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Obesity in the ageing man

(2013) K. Michalakis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Testosterone and insulin resistance in the metabolic syndrome and T2DM in men

(2013) Preethi M. Rao et al.   Nature Reviews Endocrinology

The p66Shc gene paves the way for healthspan: Evolutionary and mechanistic perspectives

(2013) Alessandra Berry et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

(2013) João Marcus Oliveira Andrade et al.   NUTRITION

Ectopic fat and adipokines in metabolically benign overweight/obese women: The kronos early estrogen prevention study

(2013) Alexandra D. Ogorodnikova et al.   Obesity

The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women's Health Initiative Observational Study

(2013) Unab I. Khan et al.   Obesity

Ectopic fat, insulin resistance and non-alcoholic fatty liver disease

(2013) Christopher D. Byrne   PROCEEDINGS OF THE NUTRITION SOCIETY

BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

(2013) Y. Yao et al.   Science Signaling

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

(2012) Nicole H. Rogers et al.   AGING CELL

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

The adipose organ at a glance

(2012) S. Cinti   Disease Models & Mechanisms

Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women

(2012) K Sanada et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Adipose Tissue

(2012) Nitzan Maixner et al.   Obesity Facts

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions

(2012) M. Snel et al.   International Journal of Endocrinology

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

The p66Shcknockout mice are short lived under natural condition

(2011) Marco Giorgio et al.   AGING CELL

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

(2011) Cagdas Tazearslan et al.   AGING CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

Ectopic Fat Depots and Cardiovascular Disease

(2011) Kathryn A. Britton et al.   CIRCULATION

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

(2011) Partha Chakrabarti et al.   JOURNAL OF LIPID RESEARCH

Interplay Between Insulin Resistance and Estrogen Deficiency as co- Activators in Carcinogenesis

(2011) Zsuzsanna Suba   PATHOLOGY & ONCOLOGY RESEARCH

Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?

(2011) Andrea Armani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

(2011) Caterina Mammi et al.   International Journal of Endocrinology

Modulation of white adipose tissue proteome by aging and calorie restriction

(2010) Adamo Valle et al.   AGING CELL

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

(2010) Gian Paolo Fadini et al.   AGING CELL

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

The Biology of Aging and Frailty

(2010) Neal S. Fedarko   CLINICS IN GERIATRIC MEDICINE

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

(2010) J. M. Curtis et al.   DIABETES

Antiadipogenic Effects of the Mineralocorticoid Receptor Antagonist Drospirenone: Potential Implications for the Treatment of Metabolic Syndrome

(2010) Massimiliano Caprio et al.   ENDOCRINOLOGY

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Testosterone and the aging male: To treat or not to treat?

(2010) Jerald Bain   MATURITAS

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

(2010) T. J. Smith   PHARMACOLOGICAL REVIEWS

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

(2010) S. C. Ranieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk

(2010) Paul Trayhurn et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)

(2009) Jingzhong Ding et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Targeted deletion ofautophagy-related 5(atg5) impairs adipogenesis in a cellular model and in mice

(2009) Rebecca Baerga et al.   Autophagy

Long-term Administration of Rapamycin Reduces Adiposity, but Impairs Glucose Tolerance in High-Fat Diet-fed KK/HlJ Mice

(2009) Geng-Ruei Chang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice

(2009) Ayumu Hirata et al.   CARDIOVASCULAR RESEARCH

Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

(2009) Adam S. Greenstein et al.   CIRCULATION

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

(2009) Geng-Ruei Chang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estradiol and the control of food intake

(2009) Peter C. Butera   PHYSIOLOGY & BEHAVIOR

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Sarcopenic obesity: definition, cause and consequences

(2008) Sari Stenholm et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

(2008) D. Demozay et al.   DIABETES

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives

(2008) Y. Rolland et al.   Journal of Nutrition Health & Aging

E2F1 regulates autophagy and the transcription of autophagy genes

(2008) S Polager et al.   ONCOGENE

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA