At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

(2010) Paolo Pinton et al.   CELL CYCLE

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing

(2010) G. P. Fadini et al.   DIABETES

The rise and fall of the metabolic syndrome

(2010) K. Borch-Johnsen et al.   DIABETOLOGIA

Development of high-fat-diet-induced obesity in female metallothionein-null mice

(2010) Masao Sato et al.   FASEB JOURNAL

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

(2010) S. C. Ranieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a

(2009) Amy R. Cameron et al.   AGING CELL

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

AMPK and the biochemistry of exercise: implications for human health and disease

(2009) Erik A. Richter et al.   BIOCHEMICAL JOURNAL

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Effects of Caloric Restriction on Cardiovascular Aging in Non-human Primates and Humans

(2009) Christina Cruzen et al.   CLINICS IN GERIATRIC MEDICINE

Apoptosis and Oxidative Stress-Related Diseases: The p66Shc Connection

(2009) Michela Pellegrini et al.   CURRENT MOLECULAR MEDICINE

The conserved role of sirtuins in chromatin regulation

(2009) Alejandro Vaquero   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion

(2009) Haemi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Superoxide Production in Macrophages of Long-lived p66Shc Knock-out Mice

(2009) Alexey A. Tomilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

(2009) Alistair VW Nunn et al.   Nutrition & Metabolism

Insulin signaling and life span

(2009) Angelo Avogaro et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

(2009) D. M. Erion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging Is RSKy Business

(2009) M. Kaeberlein et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

All-Cause and Cardiovascular Mortality Using the Different Definitions of Metabolic Syndrome

(2008) Athanase Benetos et al.   AMERICAN JOURNAL OF CARDIOLOGY

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

(2008) Mika Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuins: Novel targets for metabolic disease in drug development

(2008) Wei-jian Jiang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Metabolic Syndrome and All-Cause and Cardiovascular Mortality in an Italian Elderly Population: The Progetto Veneto Anziani (Pro.V.A.) Study

(2008) S. Zambon et al.   DIABETES CARE

Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy

(2008) D. M. Nathan et al.   DIABETOLOGIA

The Effect of Metformin on the Incidence of Type 2 Diabetes Mellitus and Cardiovascular Disease Risk Factors in Overweight and Obese Subjects – The Carmos Study

(2008) E. Andreadis et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the life span determinant P66shcA in ethanol-induced liver damage

(2008) Osvaldo R Koch et al.   LABORATORY INVESTIGATION