An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs
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Title
An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs
Authors
Keywords
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Journal
Expert Opinion on Drug Discovery
Volume 12, Issue 6, Pages 625-633
Publisher
Informa UK Limited
Online
2017-04-12
DOI
10.1080/17460441.2017.1319358
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- (2016) Daniel R. Kirienko et al. mSphere
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- (2015) Lingmei Sun et al. PLoS One
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- (2014) Rajmohan Rajamuthiah et al. PLoS One
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- (2013) Lincoln W Pasquina et al. CURRENT OPINION IN MICROBIOLOGY
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- (2013) B. P. Conlon et al. NATURE
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- Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control
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- Drug Repurposing and the Medicinal Chemist
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- (2011) Ji-Yeon Roh et al. CHEMOSPHERE
- Metabolite-enabled eradication of bacterial persisters by aminoglycosides
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- High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model
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- (2009) Jonathan G. Swoboda et al. ACS Chemical Biology
- HTS and hit finding in academia – from chemical genomics to drug discovery
- (2009) Julie A. Frearson et al. DRUG DISCOVERY TODAY
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