An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs

NH125 kills methicillin-resistantStaphylococcus aureuspersisters by lipid bilayer disruption

(2016) Wooseong Kim et al.   Future Medicinal Chemistry

Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

(2016) Beth Burgwyn Fuchs et al.   Future Medicinal Chemistry

Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin

(2016) Tatiana Johnston et al.   Future Medicinal Chemistry

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome

(2016) Philippa H. Harlow et al.   Scientific Reports

Goodbye to brute force in antibiotic discovery?

(2016) Roberto Kolter et al.   Nature Microbiology

A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and Pseudomonas aeruginosa Virulence

(2016) Daniel R. Kirienko et al.   mSphere

Insect-Derived Cecropins Display Activity against Acinetobacter baumannii in a Whole-Animal High-Throughput Caenorhabditis elegans Model

(2015) Elamparithi Jayamani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile

(2015) Rajmohan Rajamuthiah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Whole animal HTS of small molecules for antifungal compounds

(2015) Maged Muhammed et al.   Expert Opinion on Drug Discovery

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy

(2015) Wooseong Kim et al.   PLoS One

Effects of Magnolol and Honokiol on Adhesion, Yeast-Hyphal Transition, and Formation of Biofilm by Candida albicans

(2015) Lingmei Sun et al.   PLoS One

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus

(2015) Rajmohan Rajamuthiah et al.   PLoS One

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus

(2014) Rajmohan Rajamuthiah et al.   PLoS One

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death

(2013) Natalia V. Kirienko et al.   Cell Host & Microbe

Methicillin-Resistant Staphylococcus aureus: An Evolving Pathogen

(2013) M. E. Stryjewski et al.   CLINICAL INFECTIOUS DISEASES

Teichoic acid biosynthesis as an antibiotic target

(2013) Lincoln W Pasquina et al.   CURRENT OPINION IN MICROBIOLOGY

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

(2013) Stefan G. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

(2013) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gram-positive and gram-negative bacterial toxins in sepsis

(2013) Girish Ramachandran   Virulence

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Drug Repurposing and the Medicinal Chemist

(2012) Jeffrey Aubé   ACS Medicinal Chemistry Letters

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection

(2012) Read Pukkila-Worley et al.   PLoS Genetics

Cyp35a2 gene expression is involved in toxicity of fenitrothion in the soil nematode Caenorhabditis elegans

(2011) Ji-Yeon Roh et al.   CHEMOSPHERE

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

(2010) Sebastian M.B. Nijman   FEBS LETTERS

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

HTS and hit finding in academia – from chemical genomics to drug discovery

(2009) Julie A. Frearson et al.   DRUG DISCOVERY TODAY

A C. elegans-based, whole animal, in vivo screen for the identification of antifungal compounds

(2009) Emmanouil Tampakakis et al.   Nature Protocols

Waves of resistance: Staphylococcus aureus in the antibiotic era

(2009) Henry F. Chambers et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

(2009) Ikechukwu Okoli et al.   PLoS One

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

(2008) O. Gefen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans

(2008) A. Y. Peleg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Fungal Innate Immunity in C. elegans Is Enhanced by Evolutionary Diversification of Antimicrobial Peptides

(2008) Nathalie Pujol et al.   PLoS Pathogens