The nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome

NHR-176 regulatescyp-35d1to control hydroxylation-dependent metabolism of thiabendazole inCaenorhabditis elegans

(2015) Laura M. Jones et al.   BIOCHEMICAL JOURNAL

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits

(2015) Windy A. Boyd et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds

(2015) Hequn Li et al.   TOXICOLOGY IN VITRO

Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

(2015) Richard de Boer et al.   PLoS One

Toxicity Testing of Neurotoxic Pesticides inCaenorhabditis elegans

(2014) Dean Meyer et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Fishing for Teratogens: A Consortium Effort for a Harmonized Zebrafish Developmental Toxicology Assay

(2014) Jonathan S. Ball et al.   TOXICOLOGICAL SCIENCES

A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function

(2013) Patrick Allard et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adaptive and Specialised Transcriptional Responses to Xenobiotic Stress in Caenorhabditis elegans Are Regulated by Nuclear Hormone Receptors

(2013) Laura M. Jones et al.   PLoS One

Dictyostelium discoideum developmental cycle (DDDC) assay: A tool for Hg toxicity assessment and soil health screening

(2013) Amaia Rodríguez-Ruiz et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

(2013) Wolfgang Dekant et al.   TOXICOLOGY LETTERS

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines

(2012) Clemens Lamberth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 3: Imidazoles

(2012) Clemens Lamberth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preclinicalin vivoADME studies in drug development: a critical review

(2012) Mario Pellegatti   Expert Opinion on Drug Metabolism & Toxicology

Cyp35a2 gene expression is involved in toxicity of fenitrothion in the soil nematode Caenorhabditis elegans

(2011) Ji-Yeon Roh et al.   CHEMOSPHERE

Communicating Food Risks in an Era of Growing Public Distrust: Three Case Studies

(2011) Ragnar Lofstedt   RISK ANALYSIS

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family

(2011) Vuokko Aarnio et al.   Frontiers in Pharmacology

A Genetic Survey of Fluoxetine Action on Synaptic Transmission in Caenorhabditis elegans

(2010) A. Kullyev et al.   GENETICS

A Differential Role for Neuropeptides in Acute and Chronic Adaptive Responses to Alcohol: Behavioural and Genetic Analysis in Caenorhabditis elegans

(2010) Philippa Mitchell et al.   PLoS One

Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans

(2009) Patrick Schäfer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans

(2009) John A Lewis et al.   BMC GENOMICS

Cocaine Modulates Locomotion Behavior in C. elegans

(2009) Alex Ward et al.   PLoS One

Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB

(2009) Thomas B. Knudsen et al.   REPRODUCTIVE TOXICOLOGY

Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity

(2009) M. Hewitt et al.   REPRODUCTIVE TOXICOLOGY

Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression

(2008) Baby P. S. Chakrapani et al.   JOURNAL OF BIOSCIENCES

Investigating Convergent Actions of Genes Linked to Familial Parkinson’s Disease

(2008) Benjamin Wolozin et al.   Neurodegenerative Diseases

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

(2008) Maxwell C. K. Leung et al.   TOXICOLOGICAL SCIENCES

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY