The long and winding road: stem cells for cystic fibrosis

Partial Restoration of CFTR Function in cftr-Null Mice following Targeted Cell Replacement Therapy

(2017) Pascal Duchesneau et al.   MOLECULAR THERAPY

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Induced pluripotent stem cells reduce neutrophil chemotaxis via activating GRK2 in endotoxin-induced acute lung injury

(2017) Vincent Yi-Fong Su et al.   RESPIROLOGY

Innate and Adaptive Immunity in Cystic Fibrosis

(2016) Emanuela M. Bruscia et al.   CLINICS IN CHEST MEDICINE

Strategies in early clinical development for the treatment of basic defects of cystic fibrosis

(2016) Barbara Dhooghe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells

(2016) Senem Simsek et al.   Stem Cells Translational Medicine

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

(2016) Gillian M. Lavelle et al.   Biomed Research International

Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment

(2016) Morgan T. Sutton et al.   Stem Cells International

Efficient intratracheal delivery of airway epithelial cells in mice and pigs

(2015) Liqiong Gui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Generation of airway epithelial cells with native characteristics from mouse induced pluripotent stem cells

(2015) Susumu Yoshie et al.   CELL AND TISSUE RESEARCH

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients

(2015) M. D. Amaral   JOURNAL OF INTERNAL MEDICINE

Pancreatic pathophysiology in cystic fibrosis

(2015) Katherine N Gibson-Corley et al.   JOURNAL OF PATHOLOGY

Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion

(2015) Chorng-Kuang How et al.   Journal of Trauma and Acute Care Surgery

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015) Claire E. Wainwright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways

(2015) Wen Gu et al.   Scientific Reports

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs

(2015) Amy L. Firth et al.   Cell Reports

Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion

(2015) Chorng-Kuang How et al.   Journal of Trauma and Acute Care Surgery

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

(2015) Xiao-Hui Zhang et al.   Molecular Therapy-Nucleic Acids

Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans

(2015) Sharareh Shojaie et al.   Stem Cell Reports

Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects

(2015) Kelly Kuk et al.   Therapeutic Advances in Respiratory Disease

Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy

(2015) Ziying Yan et al.   Human Gene Therapy Clinical Development

Recellularization of Decellularized Lung Scaffolds Is Enhanced by Dynamic Suspension Culture

(2015) Aurélie Crabbé et al.   PLoS One

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix

(2014) Sarah E. Gilpin et al.   ANNALS OF THORACIC SURGERY

Comparative decellularization and recellularization of normal versus emphysematous human lungs

(2014) Darcy E. Wagner et al.   BIOMATERIALS

Digestive system dysfunction in cystic fibrosis: Challenges for nutrition therapy

(2014) Li Li et al.   DIGESTIVE AND LIVER DISEASE

Correction of defective CFTR/ENaC function and tightness of cystic fibrosis airway epithelium by amniotic mesenchymal stromal (stem) cells

(2014) Annalucia Carbone et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis

(2014) Daniel C. Chambers et al.   RESPIROLOGY

Are Clinical Trials With Mesenchymal Stem/Progenitor Cells too Far Ahead of the Science? Lessons From Experimental Hematology

(2014) Darwin J. Prockop et al.   STEM CELLS

Epithelial Cell Differentiation of Human Mesenchymal Stromal Cells in Decellularized Lung Scaffolds

(2014) Julio J. Mendez et al.   TISSUE ENGINEERING PART A

Paying twice: questions over high cost of cystic fibrosis drug developed with charitable funding

(2014) D. Cohen et al.   BMJ-British Medical Journal

Differentiation of Mouse Induced Pluripotent Stem Cells Into Alveolar Epithelial Cells In Vitro for Use In Vivo

(2014) Qiliang Zhou et al.   Stem Cells Translational Medicine

The effects of storage and sterilization on de-cellularized and re-cellularized whole lung

(2013) Nicholas R. Bonenfant et al.   BIOMATERIALS

The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs

(2013) Dino Sokocevic et al.   BIOMATERIALS

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Paracrine Effects and Heterogeneity of Marrow-Derived Stem/Progenitor Cells: Relevance for the Treatment of Respiratory Diseases

(2013) Massimo Conese et al.   CELLS TISSUES ORGANS

Nutritional care in children with cystic fibrosis: are our patients becoming better?

(2013) K J Gaskin   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Mesenchymal stem cell therapy in lung disorders: Pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell

(2013) Ajinkya C. Inamdar et al.   EXPERIMENTAL LUNG RESEARCH

Expert opinion in biological therapy: update on developments in lung gene transfer

(2013) Uta Griesenbach et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene

(2013) Patrick R Sosnay et al.   NATURE GENETICS

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Can stem cells be used to generate new lungs?Ex vivolung bioengineering with decellularized whole lung scaffolds

(2013) Darcy E. Wagner et al.   RESPIROLOGY

Amniotic Fluid and Placental Membranes: Unexpected Sources of Highly Multipotent Cells

(2013) Sean Murphy et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice

(2013) Ying-gang Zhu et al.   STEM CELLS

The Cystic Fibrosis of Exocrine Pancreas

(2013) M. Wilschanski et al.   Cold Spring Harbor Perspectives in Medicine

Antibiotic and Anti-Inflammatory Therapies for Cystic Fibrosis

(2013) J. F. Chmiel et al.   Cold Spring Harbor Perspectives in Medicine

Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies

(2013) Antonietta Silini et al.   Current Stem Cell Research & Therapy

Expansive Generation of Functional Airway Epithelium From Human Embryonic Stem Cells

(2013) Brendan A.S. McIntyre et al.   Stem Cells Translational Medicine

The concept of in vivo airway tissue engineering

(2012) Philipp Jungebluth et al.   BIOMATERIALS

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

(2012) Hongmei Mou et al.   Cell Stem Cell

Human Amnion Epithelial Cells do Not Abrogate Pulmonary Fibrosis in Mice with Impaired Macrophage Function

(2012) Sean V. Murphy et al.   CELL TRANSPLANTATION

Amniotic Mesenchymal Stem Cells: A New Source for Hepatocyte-Like Cells and Induction of CFTR Expression by Coculture with Cystic Fibrosis Airway Epithelial Cells

(2012) Valentina Paracchini et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

RETRACTED: Engineered whole organs and complex tissues

(2012) Stephen F Badylak et al.   LANCET

Stem Cells and Regenerative Medicine in Lung Biology and Diseases

(2012) Allison N Lau et al.   MOLECULAR THERAPY

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Human Amnion Epithelial Cells Induced to Express Functional Cystic Fibrosis Transmembrane Conductance Regulator

(2012) Sean V. Murphy et al.   PLoS One

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential

(2012) May Al-Nbaheen et al.   Stem Cell Reviews and Reports

A Nonhuman Primate Model of Lung Regeneration: Detergent-Mediated Decellularization and Initial In Vitro Recellularization with Mesenchymal Stem Cells

(2012) Ryan W. Bonvillain et al.   TISSUE ENGINEERING PART A

A Rapid Lung De-cellularization Protocol Supports Embryonic Stem Cell Differentiation In Vitro and Following Implantation

(2012) Todd Jensen et al.   TISSUE ENGINEERING PART C-METHODS

Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease

(2012) Carolien Wansleeben et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Tracheobronchial bio-engineering: Biotechnology fulfilling unmet medical needs

(2011) Thorsten Walles   ADVANCED DRUG DELIVERY REVIEWS

Epithelial Interactions and Local Engraftment of Lung-Resident Mesenchymal Stem Cells

(2011) Linda Badri et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IV Delivery of Induced Pluripotent Stem Cells Attenuates Endotoxin-Induced Acute Lung Injury in Mice

(2011) Kuang-Yao Yang et al.   CHEST

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Lung-Derived Mesenchymal Stromal Cell Post-Transplantation Survival, Persistence, Paracrine Expression, and Repair of Elastase-Injured Lung

(2011) Andrew M. Hoffman et al.   STEM CELLS AND DEVELOPMENT

Hematopoietic Stem/Progenitor Cells Express Functional Mitochondrial Energy-Dependent Cystic Fibrosis Transmembrane Conductance Regulator

(2011) Donatella Piro et al.   STEM CELLS AND DEVELOPMENT

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

Initial Binding and Recellularization of Decellularized Mouse Lung Scaffolds with Bone Marrow-Derived Mesenchymal Stromal Cells

(2011) Amanda B. Daly et al.   TISSUE ENGINEERING PART A

Comparative Assessment of Detergent-Based Protocols for Mouse Lung De-Cellularization and Re-Cellularization

(2011) John M. Wallis et al.   TISSUE ENGINEERING PART C-METHODS

Human Amnion Epithelial Cells Prevent Bleomycin-Induced Lung Injury and Preserve Lung Function

(2010) Sean Murphy et al.   CELL TRANSPLANTATION

Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach

(2010) Augustinus Bader et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Optimization of Targeted Cell Replacement Therapy: A New Approach for Lung Disease

(2010) Pascal Duchesneau et al.   MOLECULAR THERAPY

Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation

(2010) Joaquin Cortiella et al.   TISSUE ENGINEERING PART A

The RETHINK project

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Toward Cell Therapy Using Placenta-Derived Cells: Disease Mechanisms, Cell Biology, Preclinical Studies, and Regulatory Aspects at the Round Table

(2009) Ornella Parolini et al.   STEM CELLS AND DEVELOPMENT

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Adult lung side population cells have mesenchymal stem cell potential

(2008) J. Martin et al.   CYTOTHERAPY

The cystic fibrosis transmembrane conductance regulator in reproductive health and disease

(2008) Hsiao Chang Chan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Clinical transplantation of a tissue-engineered airway

(2008) Paolo Macchiarini et al.   LANCET

Stem cell therapy for cystic fibrosis: current status and future prospects

(2008) Donatella Piro et al.   Expert Review of Respiratory Medicine