Expert opinion in biological therapy: update on developments in lung gene transfer

Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion

(2016) David A. Machado-Aranda et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses

(2012) John P DeVincenzo   ANTIVIRAL THERAPY

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes

(2012) Lee A. Davies et al.   BIOMATERIALS

Progress in Gene and Cell Therapy for Cystic Fibrosis Lung Disease

(2012) Uta Griesenbach et al.   CURRENT PHARMACEUTICAL DESIGN

Ex Vivo Adenoviral Vector Gene Delivery Results in Decreased Vector-associated Inflammation Pre- and Post–lung Transplantation in the Pig

(2012) Jonathan C Yeung et al.   MOLECULAR THERAPY

Dose-response effects of TPI ASM8 in asthmatics after allergen

(2011) G. M. Gauvreau et al.   ALLERGY

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung

(2011) Reto P. Bazzani et al.   BIOMATERIALS

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer

(2011) Uta Griesenbach et al.   BIOMATERIALS

TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge

(2011) H. Imaoka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Gene Therapy for Allergic Airway Diseases

(2011) Tania Maes et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Extracorporeal lung perfusion

(2011) Marcelo Cypel et al.   Current Opinion in Organ Transplantation

Gene therapy for primary immunodeficiency

(2011) Claire Booth et al.   CURRENT OPINION IN PEDIATRICS

Progress and Prospects: Advancements in Retroviral Vector Design, Generation, and Application

(2011) Sayandip Mukherjee et al.   HUMAN GENE THERAPY

Local Long-Term Expression of Lentivirally Delivered IL-10 in the Lung Attenuates Obliteration of Intrapulmonary Allograft Airways

(2011) Shin Hirayama et al.   HUMAN GENE THERAPY

Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results

(2011) Terence R. Flotte et al.   HUMAN GENE THERAPY

The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

(2011) Christie L. Bell et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

(2011) Xinguo Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung

(2011) Corinna Pfeifer et al.   JOURNAL OF CONTROLLED RELEASE

Attacks on asthma

(2011) Sarah Webb   NATURE BIOTECHNOLOGY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Primary Ciliary Dyskinesia in Children: A Review for Pediatricians, Allergists, and Pediatric Pulmonologists

(2011) Paul C. Stillwell et al.   Pediatric Allergy Immunology and Pulmonology

Role of epithelial HCO3− transport in mucin secretion: lessons from cystic fibrosis

(2010) Paul M. Quinton   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Chemical vectors for gene delivery: uptake and intracellular trafficking

(2010) Chantal Pichon et al.   CURRENT OPINION IN BIOTECHNOLOGY

Validation of recombinant Sendai virus in a non-natural host model

(2010) U Griesenbach et al.   GENE THERAPY

The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression

(2010) J V DeGiulio et al.   GENE THERAPY

Electroporation- and mechanical ventilation-mediated gene transfer to the lung

(2010) C D Kaufman et al.   GENE THERAPY

Progress and prospects: nuclear import of nonviral vectors

(2010) A P Lam et al.   GENE THERAPY

Interleukin-10 Delivery via Mesenchymal Stem Cells: A Novel Gene Therapy Approach to Prevent Lung Ischemia–Reperfusion Injury

(2010) Eddie Manning et al.   HUMAN GENE THERAPY

Transbronchial human interleukin-10 gene transfer reduces acute inflammation associated with allograft rejection and intragraft interleukin-2 and tumor necrosis factor-α gene expression in a rat model of lung transplantation

(2010) Hisashi Oishi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Toward Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes

(2010) Katsuyuki Mitomo et al.   MOLECULAR THERAPY

Expression of Human α1-Antitrypsin in Mice and Dogs Following AAV6 Vector-mediated Gene Transfer to the Lungs

(2010) Christine L Halbert et al.   MOLECULAR THERAPY

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Learning from the Viral Journey: How to Enter Cells and How to Overcome Intracellular Barriers to Reach the Nucleus

(2009) Diky Mudhakir et al.   AAPS Journal

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

(2009) R. Alvarez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of doxorubicin in non-viral gene transfer in the lung

(2009) Uta Griesenbach et al.   BIOMATERIALS

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways

(2009) Uta Griesenbach et al.   BIOMATERIALS

Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury

(2009) Yao Qi Huang et al.   CRITICAL CARE MEDICINE

Functional Cystic Fibrosis Transmembrane Conductance Regulator Expression in Cystic Fibrosis Airway Epithelial Cells by AAV6.2-Mediated Segmental Trans-Splicing

(2009) Yuhu Song et al.   HUMAN GENE THERAPY

Identification and Functional Characterization of Cytoplasmic Determinants of Plasmid DNA Nuclear Import

(2009) Felix M. Munkonge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

(2009) Andrew A. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium

(2009) Wuping Li et al.   MOLECULAR THERAPY

Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway

(2009) Terence R Flotte et al.   MOLECULAR THERAPY

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Disorders of Surfactant Dysfunction

(2009) Susan E. Wert et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Bone Marrow Stem Cells Expressing Keratinocyte Growth Factor via an Inducible Lentivirus Protects against Bleomycin-Induced Pulmonary Fibrosis

(2009) Susana Aguilar et al.   PLoS One

Directed evolution of adeno-associated virus to an infectious respiratory virus

(2009) K. J. D. A. Excoffon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

(2009) M. L. Brantly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Repair of Human Donor Lungs by IL-10 Gene Therapy

(2009) M. Cypel et al.   Science Translational Medicine

Ciliary Beating Recovery in Deficient Human Airway Epithelial Cells after Lentivirus Ex Vivo Gene Therapy

(2009) Brigitte Chhin et al.   PLoS Genetics

Antisense Therapy against CCR3 and the Common Beta Chain Attenuates Allergen-induced Eosinophilic Responses

(2008) Gail M. Gauvreau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Frontrunners in novel pharmacotherapy of COPD

(2008) P BARNES   CURRENT OPINION IN PHARMACOLOGY

Lentivirus Vector Can Be Readministered to Nasal Epithelia without Blocking Immune Responses

(2008) P. L. Sinn et al.   JOURNAL OF VIROLOGY

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

(2008) Lee A Davies et al.   MOLECULAR THERAPY

A Receptor-targeted Nanocomplex Vector System Optimized for Respiratory Gene Transfer

(2008) Aristides D Tagalakis et al.   MOLECULAR THERAPY

Transduction Efficiencies of Novel AAV Vectors in Mouse Airway Epithelium In Vivo and Human Ciliated Airway Epithelium In Vitro

(2008) Maria P Limberis et al.   MOLECULAR THERAPY

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY