Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Authors
Keywords
-
Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 243, Issue 2, Pages 166-183
Publisher
SAGE Publications
Online
2017-12-19
DOI
10.1177/1535370217748575
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
- (2017) Christian Klein et al. OncoImmunology
- Combinations of the immunocytokine F16-IL2 with doxorubicin or with paclitaxel investigated in phase Ib studies in patients with advanced solid tumors.
- (2017) F. G. De Braud et al. JOURNAL OF CLINICAL ONCOLOGY
- Combination of the immunocytokine F16-IL2 with doxorubicin or paclitaxel in patients with solid tumors: Results from two phase Ib trials.
- (2017) F. G. De Braud et al. JOURNAL OF CLINICAL ONCOLOGY
- Fibronectin-targeted drug delivery in cancer
- (2016) Heena Kumra et al. ADVANCED DRUG DELIVERY REVIEWS
- Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions
- (2016) Franziska Bootz et al. DRUG DISCOVERY TODAY
- Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis
- (2016) Joanna Z. Kawalkowska et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site
- (2016) Jonathan D. Kiefer et al. IMMUNOLOGICAL REVIEWS
- Antibody-Based Targeted Delivery of Interleukin-22 Promotes Rapid Clinical Recovery in Mice With DSS-Induced Colitis
- (2016) Franziska Bootz et al. INFLAMMATORY BOWEL DISEASES
- GIFT4 fusokine converts leukemic B cells into immune helper cells
- (2016) Jiusheng Deng et al. Journal of Translational Medicine
- Antibody-Drug Conjugates: A Clinical Pharmacy Perspective on an Emerging Cancer Therapy
- (2016) Taleen V. Jerjian et al. PHARMACOTHERAPY
- IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)
- (2016) Anja K. Wege et al. Oncotarget
- Understanding the Supersensitive Anti-Drug Antibody Assay: Unexpected High Anti-Drug Antibody Incidence and Its Clinical Relevance
- (2016) Sam Song et al. Journal of Immunology Research
- Interleukin-22: Immunobiology and Pathology
- (2015) Jarrod A. Dudakov et al. Annual Review of Immunology
- Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters
- (2015) William R. Strohl BIODRUGS
- The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity
- (2015) Christian Hess et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study
- (2015) Riccardo Danielli et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody
- (2015) L. Xue et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease
- (2015) Lin Sun et al. CYTOKINE
- Alternatively Spliced EDA Domain of Fibronectin Is a Target for Pharmacodelivery Applications in Inflammatory Bowel Disease
- (2015) Franziska Bootz et al. INFLAMMATORY BOWEL DISEASES
- A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice
- (2015) Jinxu Fang et al. INTERNATIONAL JOURNAL OF CANCER
- An Immunosuppressive Antibody–Drug Conjugate
- (2015) Rongsheng E. Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
- (2015) Michel M van den Heuvel et al. Journal of Translational Medicine
- Therapeutic efficacy of the F8-IL2 immunocytokine in a metastatic mouse model of lung adenocarcinoma
- (2015) Sébastien Wieckowski et al. LUNG CANCER
- Abstract C173: Anti-PD-L1 antibody-based IL-15 immunocytokine has enhanced antitumor immunity
- (2015) Yan Wu et al. MOLECULAR CANCER THERAPEUTICS
- IL-6 as a keystone cytokine in health and disease
- (2015) Christopher A Hunter et al. NATURE IMMUNOLOGY
- Antibody fusions with immunomodulatory proteins for cancer therapy
- (2015) Dafne Müller PHARMACOLOGY & THERAPEUTICS
- Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies
- (2015) Dario Venetz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Targeted Delivery of Interleukin 4 Inhibits Development of Endometriotic Lesions in a Mouse Model
- (2015) Federica Quattrone et al. Reproductive Sciences
- Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12
- (2015) Theofanis Floros et al. SEMINARS IN ONCOLOGY
- Tenascin-C and integrins in cancer
- (2015) Toshimichi Yoshida et al. Cell Adhesion & Migration
- The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer
- (2015) Chiara Catania et al. Cell Adhesion & Migration
- Targeting Interleukin-2 to the Bone Marrow Stroma for Therapy of Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation
- (2015) Christoph Schliemann et al. Cancer Immunology Research
- Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
- (2015) Paul C. McDonald et al. Oncotarget
- FRI0194 A phase IB clinical trial with dekavil (F8-IL10), an anti-inflammatory immunocytokine for the treatment of rheumatoid arthritis, used in combination with methotrexate
- (2014) M. Galeazzi et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin 12: still a promising candidate for tumor immunotherapy?
- (2014) Witold Lasek et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation
- (2014) K. Kim et al. CARCINOGENESIS
- Side Effects of Cytokines Approved for Therapy
- (2014) Brian A. Baldo DRUG SAFETY
- Interleukin-15 in the treatment of cancer
- (2014) Thomas A Waldmann Expert Review of Clinical Immunology
- Development trends for generation of single-chain antibody fragments
- (2014) Safar Farajnia et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation
- (2014) Teresa Hemmerle et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity
- (2014) A. Krippner-Heidenreich et al. JOURNAL OF IMMUNOLOGY
- A Chemically Defined Trifunctional Antibody-Cytokine-Drug Conjugate with Potent Antitumor Activity
- (2014) T. List et al. MOLECULAR CANCER THERAPEUTICS
- Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
- (2014) Xiaoting Wang et al. NATURE
- Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
- (2014) Sumaira Z Hasnain et al. NATURE MEDICINE
- Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis
- (2014) T. Hemmerle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibodies and their Multivalent Constructs for Cancer Therapy
- (2014) Qing Li et al. PROTEIN AND PEPTIDE LETTERS
- Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6
- (2014) Christian Hess et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency
- (2014) Chris Hughes et al. ARTHRITIS RESEARCH & THERAPY
- Concise Review: Engineering the Fusion of Cytokines for the Modulation of Immune Cellular Responses in Cancer and Autoimmune Disorders
- (2014) Spencer Ng et al. Stem Cells Translational Medicine
- Interleukin-7 and Interleukin-15 for Cancer
- (2014) Paul Zarogoulidis et al. Journal of Cancer
- Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19-IL2 Results in Sustained Clinical and Systemic Immunologic Responses
- (2014) B. Weide et al. Cancer Immunology Research
- A phase 1b study of humanized KS-interleukin-2 (huKS-IL2) immunocytokine with cyclophosphamide in patients with EpCAM-positive advanced solid tumors
- (2013) Joseph P Connor et al. BMC CANCER
- IL-22, not simply a Th17 cytokine
- (2013) Sascha Rutz et al. IMMUNOLOGICAL REVIEWS
- Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency
- (2013) Marie Vincent et al. INTERNATIONAL JOURNAL OF CANCER
- The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer
- (2013) Teresa Hemmerle et al. INTERNATIONAL JOURNAL OF CANCER
- Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
- (2013) Stefanie Kirchberger et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy
- (2013) V. Kermer et al. MOLECULAR CANCER THERAPEUTICS
- Therapeutic opportunities of the IL-22–IL-22R1 system
- (2013) Robert Sabat et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
- (2013) Xin Yao et al. PHARMACOLOGY & THERAPEUTICS
- A Fusion Cytokine Coupling GMCSF to IL9 Induces Heterologous Receptor Clustering and STAT1 Hyperactivation through JAK2 Promiscuity
- (2013) Pingxin Li et al. PLoS One
- Novel Immunocytokine IL12-SS1 (Fv) Inhibits Mesothelioma Tumor Growth in Nude Mice
- (2013) Heungnam Kim et al. PLoS One
- Antitumor activity of an immunocytokine composed of an anti-GD2 antibody and the IL-15 superagonist RLI
- (2013) Marie Vincent et al. OncoImmunology
- Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
- (2012) Narendra Chirmule et al. AAPS Journal
- Antibody–cytokine fusion proteins
- (2012) Roland E. Kontermann ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Phase II trial of hu14.18-IL2 for patients with metastatic melanoma
- (2012) Mark R. Albertini et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel
- (2012) N. Pasche et al. CLINICAL CANCER RESEARCH
- Immunocytokines: a novel class of potent armed antibodies
- (2012) Nadine Pasche et al. DRUG DISCOVERY TODAY
- Amazing IL-9: revealing a new function for an “old” cytokine
- (2012) Edgar Schmitt et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-4 in the Brain: A Cytokine To Remember
- (2012) Sachin P. Gadani et al. JOURNAL OF IMMUNOLOGY
- IFN- in the Treatment of Melanoma
- (2012) A. A. Tarhini et al. JOURNAL OF IMMUNOLOGY
- An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 trans -Presentation at the Tumor Site
- (2012) Vanessa Kermer et al. MOLECULAR CANCER THERAPEUTICS
- Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family
- (2012) Lindsay L. Jones et al. MOLECULAR IMMUNOLOGY
- Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone
- (2012) Jonas H Graversen et al. MOLECULAR THERAPY
- Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
- (2012) Rahul Purwar et al. NATURE MEDICINE
- IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
- (2012) Florent Carrette et al. SEMINARS IN IMMUNOLOGY
- Macrophage-Targeted Therapy: CD64-Based Immunotoxins for Treatment of Chronic Inflammatory Diseases
- (2012) Dmitrij Hristodorov et al. Toxins
- The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate
- (2011) Nadine Pasche et al. ANGIOGENESIS
- Local delivery of IL-2 reduces atherosclerosis via expansion of regulatory T cells
- (2011) Thore Dietrich et al. ATHEROSCLEROSIS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma
- (2011) T. K. Eigentler et al. CLINICAL CANCER RESEARCH
- A Phase 1 Study of AS1409, a Novel Antibody-Cytokine Fusion Protein, in Patients with Malignant Melanoma or Renal Cell Carcinoma
- (2011) S. M. Rudman et al. CLINICAL CANCER RESEARCH
- The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model
- (2011) Kathrin Schwager et al. HUMAN REPRODUCTION
- Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7
- (2011) Nadine Pasche et al. JOURNAL OF BIOTECHNOLOGY
- Neonatal Fc receptor and IgG-based therapeutics
- (2011) Timothy T. Kuo et al. mAbs
- Human single-chain variable fragment that specifically targets arthritic cartilage
- (2010) Chris Hughes et al. ARTHRITIS AND RHEUMATISM
- Prediction of Immunogenicity of Therapeutic Proteins
- (2010) Christine J. Bryson et al. BIODRUGS
- Immunity, Inflammation, and Cancer
- (2010) Sergei I. Grivennikov et al. CELL
- IL-10 family of cytokines
- (2010) Robert Sabat CYTOKINE & GROWTH FACTOR REVIEWS
- Biology of interleukin-10
- (2010) Robert Sabat et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma
- (2010) Manfred Johannsen et al. EUROPEAN JOURNAL OF CANCER
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
- (2010) Thomas R. Malek et al. IMMUNITY
- Antitumor Activity of Hu14.18-IL2 in Patients With Relapsed/Refractory Neuroblastoma: A Children's Oncology Group (COG) Phase II Study
- (2010) Suzanne Shusterman et al. JOURNAL OF CLINICAL ONCOLOGY
- GMCSF-Interleukin fusion cytokines induce novel immune effectors that can serve as biopharmaceuticals for treatment of autoimmunity and cancer
- (2010) P. Williams et al. JOURNAL OF INTERNAL MEDICINE
- The immunogenicity of humanized and fully human antibodies
- (2010) Fiona A. Harding et al. mAbs
- Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
- (2010) Toshio HIRANO PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12
- (2010) Roberto Sommavilla et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Comparative immunohistochemical staining of atherosclerotic plaques using F16, F8 and L19: Three clinical-grade fully human antibodies
- (2009) Marta Pedretti et al. ATHEROSCLEROSIS
- A Proteomic Approach for the Identification of Vascular Markers of Liver Metastasis
- (2009) B. Borgia et al. CANCER RESEARCH
- Fcγ Receptor 1 (CD64), a Target Beyond Cancer
- (2009) T. Thepen et al. CURRENT PHARMACEUTICAL DESIGN
- Mechanisms of Tumor Cell Necrosis
- (2009) Sergey Proskuryakov et al. CURRENT PHARMACEUTICAL DESIGN
- Protumor vs Antitumor Functions of IL-17
- (2009) G. Murugaiyan et al. JOURNAL OF IMMUNOLOGY
- Interleukin 22 Receptor 1 Expression in Pancreas Islets
- (2009) Makoto Shioya et al. PANCREAS
- Enhancement of antitumor immune response by targeted interleukin-12 electrogene transfer through antiHER2 single-chain antibody in a murine bladder tumor model
- (2009) Yuh-Shyan Tsai et al. VACCINE
- Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis
- (2009) Kathrin Schwager et al. ARTHRITIS RESEARCH & THERAPY
- Immune Therapy for Cancer
- (2008) Michael Dougan et al. Annual Review of Immunology
- Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
- (2008) C. Schliemann et al. BLOOD
- Clinical uses of interferons
- (2008) Robert M. Friedman BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The Targeted Immunocytokine L19-IL2 Efficiently Inhibits the Growth of Orthotopic Pancreatic Cancer
- (2008) K. Wagner et al. CLINICAL CANCER RESEARCH
- Antibody-Mediated Delivery of Interleukin-2 to the Stroma of Breast Cancer Strongly Enhances the Potency of Chemotherapy
- (2008) J. Marlind et al. CLINICAL CANCER RESEARCH
- Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
- (2008) Lauren A. Zenewicz et al. IMMUNITY
- New Approaches to Prediction of Immune Responses to Therapeutic Proteins during Preclinical Development
- (2008) Laura C A Perry et al. Drugs in research & development
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now