Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

(2014) Verena Rombach-Riegraf et al.   PLoS One

B-cell memory and primary immune deficiencies

(2013) Marylin Desjardins et al.   Current Opinion in Allergy and Clinical Immunology

Controlling immune responses by targeting antigens to dendritic cell subsets and B cells

(2013) Craig P. Chappell et al.   INTERNATIONAL IMMUNOLOGY

Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study

(2013) Fei Hua et al.   JOURNAL OF CLINICAL PHARMACOLOGY

IL-21 Enhances Phagocytosis in Mononuclear Phagocyte Cells: Identification of Spleen Tyrosine Kinase as a Novel Molecular Target of IL-21

(2013) F. Vallieres et al.   JOURNAL OF IMMUNOLOGY

T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice

(2013) Xue Yang et al.   PLoS One

The nature of activatory and tolerogenic dendritic cell-derived signal II

(2013) Ghaith Bakdash et al.   Frontiers in Immunology

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Considerations for optimization and validation of an in vitro PBMC derived T cell assay for immunogenicity prediction of biotherapeutics

(2010) Danika Wullner et al.   CLINICAL IMMUNOLOGY

IL-21 Receptor Is Critical for the Development of Memory B Cell Responses

(2010) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

(2010) Yongjing Guo et al.   Journal of Translational Medicine

In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

(2010) Yulia Vugmeyster et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Endosomal sorting of MHC class II determines antigen presentation by dendritic cells

(2008) Guillaume van Niel et al.   CURRENT OPINION IN CELL BIOLOGY

Dendritic cells and cytokines in human inflammatory and autoimmune diseases

(2008) P BLANCO et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

(2008) Ralph M. Steinman   IMMUNITY

Interleukin 21: a cytokine/cytokine receptor system that has come of age

(2008) Warren J. Leonard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology