The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer

Antibody–cytokine fusion proteins

(2012) Roland E. Kontermann   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Paclitaxel Enhances Therapeutic Efficacy of the F8-IL2 Immunocytokine to EDA-Fibronectin-Positive Metastatic Human Melanoma Xenografts

(2012) M. Moschetta et al.   CANCER RESEARCH

The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel

(2012) N. Pasche et al.   CLINICAL CANCER RESEARCH

Immunocytokines: a novel class of potent armed antibodies

(2012) Nadine Pasche et al.   DRUG DISCOVERY TODAY

Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma

(2012) Francesco Papadia et al.   JOURNAL OF SURGICAL ONCOLOGY

The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate

(2011) Nadine Pasche et al.   ANGIOGENESIS

A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma

(2011) T. K. Eigentler et al.   CLINICAL CANCER RESEARCH

The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model

(2011) Kathrin Schwager et al.   HUMAN REPRODUCTION

Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation

(2011) Katharina Frey et al.   Integrative Biology

Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7

(2011) Nadine Pasche et al.   JOURNAL OF BIOTECHNOLOGY

A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer

(2011) Kathrin Schwager et al.   Head and Neck Optical Diagnostics Society

Combination of temozolomide with immunocytokine F16–IL2 for the treatment of glioblastoma

(2010) M Pedretti et al.   BRITISH JOURNAL OF CANCER

Phase II Study of Interleukin-4 in Indolent B-cell Non-Hodgkin Lymphoma and B-cell Chronic Lymphocytic Leukemia: A Study of the Eastern Cooperative Oncology Group (E5Y92)

(2010) Peter H. Wiernik et al.   JOURNAL OF IMMUNOTHERAPY

The Immunocytokine F8-IL2 Improves the Therapeutic Performance of Sunitinib in a Mouse Model of Renal Cell Carcinoma

(2010) Katharina Frey et al.   JOURNAL OF UROLOGY

Comparative immunohistochemical staining of atherosclerotic plaques using F16, F8 and L19: Three clinical-grade fully human antibodies

(2009) Marta Pedretti et al.   ATHEROSCLEROSIS

Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients

(2009) S. Sauer et al.   BLOOD

Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma

(2009) Christoph Schliemann et al.   LEUKEMIA RESEARCH

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

(2009) Kathrin Schwager et al.   ARTHRITIS RESEARCH & THERAPY

Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2

(2008) C. Schliemann et al.   BLOOD

Crucial Role of Interleukin-4 in the Survival of Colon Cancer Stem Cells

(2008) M. G. Francipane et al.   CANCER RESEARCH

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: Two human antibodies investigated in clinical trials in patients with cancer

(2008) Marta Pedretti et al.   LUNG CANCER