Concise Review: Engineering the Fusion of Cytokines for the Modulation of Immune Cellular Responses in Cancer and Autoimmune Disorders

Engineered Fusokine GIFT4 Licenses the Ability of B Cells to Trigger a Tumoricidal T-cell Response

(2014) J. Deng et al.   CANCER RESEARCH

Regulatory B cells in autoimmune diseases

(2013) Min Yang et al.   Cellular & Molecular Immunology

The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells

(2013) Chi-Keung Wan et al.   IMMUNITY

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

A Fusion Cytokine Coupling GMCSF to IL9 Induces Heterologous Receptor Clustering and STAT1 Hyperactivation through JAK2 Promiscuity

(2013) Pingxin Li et al.   PLoS One

IL-10–Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation

(2012) Min Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

IL-2 and IL-15 signaling complexes: different but the same

(2012) Shinji Ikemizu et al.   NATURE IMMUNOLOGY

FIST, a sword and shield fusokine for cancer immunotherapy

(2012) Claudia Penafuerte et al.   OncoImmunology

GM-CSF-Based Fusion Cytokines as Ligands for Immune Modulation

(2011) P. Williams et al.   JOURNAL OF IMMUNOLOGY

A Brief History of IL-9

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

A Dendritic Cell Population Generated by a Fusion of GM-CSF and IL-21 Induces Tumor-Antigen-Specific Immunity

(2010) P. Williams et al.   JOURNAL OF IMMUNOLOGY

A Fusion of GMCSF and IL-21 Initiates Hypersignaling Through the IL-21Rα Chain With Immune Activating and Tumoricidal Effects In Vivo

(2010) Patrick Williams et al.   MOLECULAR THERAPY

Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation

(2009) Ernestina Saulle et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Human Ortholog of Granulocyte Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion Protein Induces Potent Ex vivo Natural Killer Cell Activation and Maturation

(2009) C. Penafuerte et al.   CANCER RESEARCH

A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties

(2009) Moutih Rafei et al.   NATURE MEDICINE

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY