Neonatal Fc receptor and IgG-based therapeutics

Field flow fractionation for assessing neonatal Fc receptor and Fcγ receptor binding to monoclonal antibodies in solution

(2011) Joey Pollastrini et al.   ANALYTICAL BIOCHEMISTRY

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen

(2011) Attila Végh et al.   mAbs

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

(2011) Weirong Wang et al.   MOLECULAR IMMUNOLOGY

Efficient mucosal vaccination mediated by the neonatal Fc receptor

(2011) Lilin Ye et al.   NATURE BIOTECHNOLOGY

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner

(2010) Kyosuke Nakata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prolonged activity of factor IX as a monomeric Fc fusion protein

(2010) R. T. Peters et al.   BLOOD

Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-  Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys

(2010) R. Deng et al.   DRUG METABOLISM AND DISPOSITION

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

(2010) Adam R. Mezo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neonatal Fc Receptor: From Immunity to Therapeutics

(2010) Timothy T. Kuo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

(2010) J. Cervenak et al.   JOURNAL OF IMMUNOLOGY

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins

(2010) V. E. Kenanova et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Investigation of the Influence of FcRn on the Distribution of IgG to the Brain

(2009) Amit Garg et al.   AAPS Journal

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG

(2009) Timothy T. Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-species Binding Analyses of Mouse and Human Neonatal Fc Receptor Show Dramatic Differences in Immunoglobulin G and Albumin Binding

(2009) Jan Terje Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biodistribution of a Bispecific Single-chain Diabody and Its Half-life Extended Derivatives

(2009) Roland Stork et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

(2009) Salit Tzaban et al.   JOURNAL OF CELL BIOLOGY

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG

(2009) M. Sarav et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structural characterization of a human Fc fragment engineered for extended serum half-life

(2009) Vaheh Oganesyan et al.   MOLECULAR IMMUNOLOGY

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

(2009) Héctor Pérez Montoyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn

(2009) Kristi Baker et al.   Seminars in Immunopathology

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

(2008) A. R. Mezo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infused Fc-tagged  -glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice

(2008) J. H. Grubb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Podocytes use FcRn to clear IgG from the glomerular basement membrane

(2008) S. Akilesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence of antibody-mediated presentation of antigen on FcRn

(2008) S.-W. Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neonatal Fc receptor plays a crucial role in the metabolism of IgG in livestock animals

(2008) Judit Cervenak et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY