Radioresistance of Brain Tumors

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

(2016) Sung-Hak Kim et al.   CANCER CELL

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

(2016) Lindsey M. Hoffman et al.   Acta Neuropathologica Communications

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma

(2015) Zangbéwendé Guy Ouédraogo et al.   BRAIN PATHOLOGY

Contribution of the immune system to bystander and non-targeted effects of ionizing radiation

(2015) Franz Rödel et al.   CANCER LETTERS

Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects

(2015) Carl N. Sprung et al.   CANCER LETTERS

The role of oxidative DNA damage in radiation induced bystander effect

(2015) Sophia Havaki et al.   CANCER LETTERS

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

(2015) S. U. Ahmed et al.   CANCER RESEARCH

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

(2015) D.-C. Lin et al.   CANCER RESEARCH

DNA Damage-Induced NF-κB Activation in Human Glioblastoma Cells Promotes miR-181b Expression and Cell Proliferation

(2015) Rui-Xue Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology

(2015) Alba A. Brandes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Repair mechanisms help glioblastoma resist treatment

(2015) Ryan J. Atkins et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition

(2015) M. Mehta et al.   MOLECULAR CANCER THERAPEUTICS

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Radiosurgery for Pediatric Brain Tumors

(2015) Erin S. Murphy et al.   PEDIATRIC BLOOD & CANCER

Organs at risk in the brain and their dose-constraints in adults and in children: A radiation oncologist’s guide for delineation in everyday practice

(2015) Silvia Scoccianti et al.   RADIOTHERAPY AND ONCOLOGY

Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones

(2015) Delphine Séhédic et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

EGFRAmplification and Glioblastoma Stem-Like Cells

(2015) Katrin Liffers et al.   Stem Cells International

Genetic and Functional Diversity of Propagating Cells in Glioblastoma

(2015) Sara G.M. Piccirillo et al.   Stem Cell Reports

Notching on Cancer’s Door: Notch Signaling in Brain Tumors

(2015) Marcin Teodorczyk et al.   Frontiers in Oncology

Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma

(2015) Emily Padfield et al.   Frontiers in Oncology

Bmi1 Is Required for Hedgehog Pathway-Driven Medulloblastoma Expansion

(2015) Lowell Evan Michael et al.   NEOPLASIA

Microenvironment and Brain Tumor Stem Cell Maintenance: Impact of the Niche

(2014) Christel Herold-Mende et al.   Anti-Cancer Agents in Medicinal Chemistry

Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

(2014) Eun Jung Choi et al.   BMC CANCER

Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules

(2014) Kevin Leder et al.   CELL

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Preclinical evidence that SSR128129E – A novel small-molecule multi-fibroblast growth factor receptor blocker – Radiosensitises human glioblastoma

(2014) Isabelle Ader et al.   EUROPEAN JOURNAL OF CANCER

Radiobiological basis of SBRT and SRS

(2014) Chang W. Song et al.   International Journal of Clinical Oncology

Radiation-induced signaling pathways that promote cancer cell survival (Review)

(2014) ASHLEY L. HEIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?

(2014) J. Martin Brown et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Combined EGFR and Autophagy Modulation Impairs Cell Migration and Enhances Radiosensitivity in Human Glioblastoma Cells

(2014) Silvia Palumbo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of Synthetic Lethality Anticancer Therapeutics

(2014) Bingliang Fang   JOURNAL OF MEDICINAL CHEMISTRY

Wnt activation affects proliferation, invasiveness and radiosensitivity in medulloblastoma

(2014) Roberta Salaroli et al.   JOURNAL OF NEURO-ONCOLOGY

Aberrant self-renewal and quiescence contribute to the aggressiveness of glioblastoma

(2014) Benito Campos et al.   JOURNAL OF PATHOLOGY

RhoB Promotes γH2AX Dephosphorylation and DNA Double-Strand Break Repair

(2014) Kenza Mamouni et al.   MOLECULAR AND CELLULAR BIOLOGY

Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase

(2014) Ross Carruthers et al.   Molecular Oncology

Editorial on "targeting Wee1 for the treatment of pediatric high-grade gliomas"

(2014) A. Chakravarti   NEURO-ONCOLOGY

Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

(2014) Matthew Womeldorff et al.   Neurosurgical Focus

Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma

(2014) Mehdi Shahi et al.   ONCOLOGY REPORTS

Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia

(2014) Ian S. Miller et al.   PLoS One

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

(2014) J. Halliday et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Stereotactic radiosurgery for treatment of brain metastases

(2014) Martin Kocher et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1

(2014) Eun-Jung Kim et al.   TUMOR BIOLOGY

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

(2013) Wen-juan Wang et al.   ACTA PHARMACOLOGICA SINICA

The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption

(2013) Hironobu Yasui et al.   BMC CANCER

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The role of basic fibroblast growth factor in glioblastoma multiforme and glioblastoma stem cells and in their in vitro culture

(2013) Elizabeth M. Haley et al.   CANCER LETTERS

Radioresistant Cancer Cells Can Be Conditioned to Enter Senescence by mTOR Inhibition

(2013) H. Y. Nam et al.   CANCER RESEARCH

Wee1 kinase as a target for cancer therapy

(2013) Khanh Do et al.   CELL CYCLE

ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation

(2013) L. Biddlestone-Thorpe et al.   CLINICAL CANCER RESEARCH

Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma

(2013) Carlos Rodrigo Gil del Alcazar et al.   CLINICAL CANCER RESEARCH

Essential Role of Gli Proteins in Glioblastoma Multiforme

(2013) Matteo Santoni et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

αvβ3 Integrin and Fibroblast growth factor receptor 1 (FGFR1): Prognostic factors in a phase I–II clinical trial associating continuous administration of Tipifarnib with radiotherapy for patients with newly diagnosed glioblastoma

(2013) Anne Ducassou et al.   EUROPEAN JOURNAL OF CANCER

Pulsed Versus Conventional Radiation Therapy in Combination With Temozolomide in a Murine Orthotopic Model of Glioblastoma Multiforme

(2013) David Y. Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Stereotactic radiosurgery for brain and spine metastases

(2013) Patrick J. Bowden et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Brain tumor stem cells: Molecular characteristics and their impact on therapy

(2013) David L. Schonberg et al.   MOLECULAR ASPECTS OF MEDICINE

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

4D VMAT, gated VMAT, and 3D VMAT for stereotactic body radiation therapy in lung

(2013) E Chin et al.   PHYSICS IN MEDICINE AND BIOLOGY

Knockdown of FRAT1 Expression by RNA Interference Inhibits Human Glioblastoma Cell Growth, Migration and Invasion

(2013) Geng Guo et al.   PLoS One

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma

(2013) Lara Barazzuol et al.   Radiation Oncology

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells

(2013) Satoru Osuka et al.   STEM CELLS

A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells

(2013) Norihiko Saito et al.   STEM CELLS

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα

(2013) S Sinha et al.   Cell Death & Disease

Clinical Outcomes of Gamma Knife Radiosurgery in the Salvage Treatment of Patients with Recurrent High-Grade Glioma

(2013) Ameer L. Elaimy et al.   World Neurosurgery

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

The Combination of Novel Targeted Molecular Agents and Radiation in the Treatment of Pediatric Gliomas

(2013) Tina Dasgupta et al.   Frontiers in Oncology

Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β

(2012) Matthew E. Hardee et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Role of a DNA Damage Checkpoint Pathway in Ionizing Radiation-Induced Glioblastoma Cell Migration and Invasion

(2012) Issai Vanan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The sonic hedgehog-GLI1 signaling pathway in brain tumor development

(2012) Mehdi H Shahi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual PI3K/mTOR Inhibitor NVP-BEZ235

(2012) A. Maity et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

International Spine Radiosurgery Consortium Consensus Guidelines for Target Volume Definition in Spinal Stereotactic Radiosurgery

(2012) Brett W. Cox et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas

(2012) V. Caretti et al.   MOLECULAR CANCER THERAPEUTICS

Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding

(2011) Alan Siu et al.   ACTA NEUROCHIRURGICA

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

(2011) J M Heddleston et al.   CELL DEATH AND DIFFERENTIATION

Genomic Profiles of Glioma

(2011) Cameron Brennan   Current Neurology and Neuroscience Reports

Targeting the AKT Pathway in Glioblastoma

(2011) Kelli A. McDowell et al.   CURRENT PHARMACEUTICAL DESIGN

Glioma Stem Cell Maintenance: The Role of the Microenvironment

(2011) John M. Heddleston et al.   CURRENT PHARMACEUTICAL DESIGN

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

(2011) Lin Cheng et al.   EMBO JOURNAL

Dose Escalation for Prostate Cancer Radiotherapy: Predictors of Long-Term Biochemical Tumor Control and Distant Metastases–Free Survival Outcomes

(2011) Michael J. Zelefsky et al.   EUROPEAN UROLOGY

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis

(2011) Yi-Ping Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt activation is implicated in glioblastoma radioresistance

(2011) Yonghyun Kim et al.   LABORATORY INVESTIGATION

Targeting Radiation-Induced G2 Checkpoint Activation with the Wee-1 Inhibitor MK-1775 in Glioblastoma Cell Lines

(2011) B. Sarcar et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

(2011) G. Prasad et al.   NEURO-ONCOLOGY

Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes

(2011) K. Edelstein et al.   NEURO-ONCOLOGY

Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells

(2011) X Wang et al.   ONCOGENE

The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage

(2011) Melissa C. Srougi et al.   PLoS One

Clinical practice of image-guided spine radiosurgery - results from an international research consortium

(2011) Matthias Guckenberger et al.   Radiation Oncology

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

(2011) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions

(2011) J D Lathia et al.   Cell Death & Disease

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

The expression profile of FRAT1 in human gliomas

(2010) Geng Guo et al.   BRAIN RESEARCH

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

(2010) Shahryar E. Mir et al.   CANCER CELL

PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas

(2010) Hongwu Zheng et al.   CANCER CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Combination of Temsirolimus (CCI-779) with Chemoradiation in Newly Diagnosed Glioblastoma Multiforme (GBM) (NCCTG trial N027D) Is Associated with Increased Infectious Risks

(2010) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH

Microenvironmental Regulation of Glioblastoma Radioresponse

(2010) M. Jamal et al.   CLINICAL CANCER RESEARCH

NF-κB and STAT3 signaling in glioma: targets for future therapies

(2010) George P Atkinson et al.   Expert Review of Neurotherapeutics

Fractionated Stereotactic Radiosurgery for Reirradiation of Head-and-Neck Cancer

(2010) Keith R. Unger et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

North Central Cancer Treatment Group Phase I Trial N057K of Everolimus (RAD001) and Temozolomide in Combination With Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Jann N. Sarkaria et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?

(2010) Hiroshi Onishi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Stereotactic Body Radiation Therapy for Inoperable Early Stage Lung Cancer

(2010) Robert Timmerman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cells

(2010) Antony Hsieh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth

(2010) Zhan-xiang Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Sonic Hedgehog signaling in the mammalian brain

(2010) Elisabeth Traiffort et al.   JOURNAL OF NEUROCHEMISTRY

A Phase II study of anti–epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme

(2010) Linna Li et al.   JOURNAL OF NEUROSURGERY

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

(2010) Li Lin et al.   Molecular Cancer

Prolonged survival for patients with newly diagnosed, inoperable glioblastoma with 3-times daily ultrafractionated radiation therapy

(2010) P. Beauchesne et al.   NEURO-ONCOLOGY

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

(2010) J Bartkova et al.   ONCOGENE

Nuclear phosphoinositide 3-kinase   controls double-strand break DNA repair

(2010) A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma

(2010) Koji Kawaguchi et al.   Radiation Oncology

Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance

(2010) Nathan Moore et al.   Journal of Oncology

The role of autophagy in sensitizing malignant glioma cells to radiation therapy

(2009) W. Zhuang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma

(2009) Tomoo Matsutani et al.   ACTA NEUROCHIRURGICA

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Current Perspectives on Akt Akt-ivation and Akt-ions

(2009) Ronald W. Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Brain tumor treatment increases the number of cancer stem-like cells

(2009) Nikki Charles et al.   Expert Review of Neurotherapeutics

The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

Feasibility of Single-Isocenter Volumetric Modulated Arc Radiosurgery for Treatment of Multiple Brain Metastases

(2009) Grant M. Clark et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

(2009) M. Abdouh et al.   JOURNAL OF NEUROSCIENCE

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

(2009) G. L. Gallia et al.   MOLECULAR CANCER THERAPEUTICS

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

(2009) T.-J. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines

(2009) M. J. Clarke et al.   MOLECULAR CANCER THERAPEUTICS

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

(2009) S G M Piccirillo et al.   ONCOGENE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

(2009) Hui-Fang Li et al.   Radiation Oncology

Radiotherapy and radiosurgery for benign skull base meningiomas

(2009) Giuseppe Minniti et al.   Radiation Oncology

Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer

(2009) Dirk Wolff et al.   RADIOTHERAPY AND ONCOLOGY

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

αvβ3 and αvβ5 integrins control glioma cell response to ionising radiation through ILK and RhoB

(2008) Sylvie Monferran et al.   INTERNATIONAL JOURNAL OF CANCER

Radiation Dose Prescription for Non–Small-Cell Lung Cancer According to Normal Tissue Dose Constraints: An In Silico Clinical Trial

(2008) Angela van Baardwijk et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase I Three-Dimensional Conformal Radiation Dose Escalation Study in Newly Diagnosed Glioblastoma: Radiation Therapy Oncology Group Trial 98-03

(2008) Christina Tsien et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas

(2008) Dieta Brandsma et al.   LANCET ONCOLOGY

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Glioma Formation, Cancer Stem Cells, and Akt Signaling

(2008) Dolores Hambardzumyan et al.   Stem Cell Reviews and Reports

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

(2008) Christine E. Eyler et al.   STEM CELLS

Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer

(2007) Deborah A. Kuban et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS