Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma

(2015) Sri Hari Krishna Vellanki et al.   NEOPLASIA

The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells

(2015) Muhammad Jamal et al.   NEOPLASIA

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression

(2013) Ruopeng Feng et al.   BIOCHEMICAL JOURNAL

HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage

(2013) Ji-hyun Ju et al.   BIOCHEMICAL JOURNAL

Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide

(2013) J Sherriff et al.   BRITISH JOURNAL OF RADIOLOGY

Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: Effects associated with STAT3/Survivin

(2013) Kunming Wen et al.   CANCER LETTERS

Treat cancers by targeting survivin: Just a dream or future reality?

(2013) Mohane Selvaraj Coumar et al.   CANCER TREATMENT REVIEWS

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

(2013) M Venere et al.   CELL DEATH AND DIFFERENTIATION

Radiation-induced mitotic cell death and glioblastoma radioresistance: A new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1alpha and survivin in U87 cells

(2013) Olivia Lanvin et al.   EUROPEAN JOURNAL OF CANCER

Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells

(2013) Satoru Osuka et al.   STEM CELLS

Transcriptional Differences between Normal and Glioma-Derived Glial Progenitor Cells Identify a Core Set of Dysregulated Genes

(2013) Romane M. Auvergne et al.   Cell Reports

Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β

(2012) Matthew E. Hardee et al.   CANCER RESEARCH

Regulation of glioblastoma multiforme stem-like cells by inhibitor of DNA binding proteins and oligodendroglial lineage-associated transcription factors

(2012) Yanjue Wu et al.   CANCER SCIENCE

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin-Ran Protein Complex

(2012) H. Guvenc et al.   CLINICAL CANCER RESEARCH

Gefitinib Radiosensitizes Stem-Like Glioma Cells: Inhibition of Epidermal Growth Factor Receptor-Akt-DNA-PK Signaling, Accompanied by Inhibition of DNA Double-Strand Break Repair

(2012) Khong Bee Kang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells

(2012) Y. C. Lim et al.   MOLECULAR CANCER THERAPEUTICS

Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region

(2012) E. Iscru et al.   NEUROSCIENCE

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Survivin in Solid Tumors: Rationale for Development of Inhibitors

(2012) David N. Church et al.   Current Oncology Reports

Human Glioblastoma Stem-Like Cells are More Sensitive to Allogeneic NK and T Cell-Mediated Killing Compared with Serum-Cultured Glioblastoma Cells

(2011) Tony Avril et al.   BRAIN PATHOLOGY

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Targeting survivin in cancer: the cell-signalling perspective

(2011) Jagat R. Kanwar et al.   DRUG DISCOVERY TODAY

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of the Stem Cell Marker, Nanog, in Human Endometrial Adenocarcinoma

(2011) Xi Zhou et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Importance of PKC  signaling in fractionated-radiation-induced expansion of glioma-initiating cells and resistance to cancer treatment

(2011) M.-J. Kim et al.   JOURNAL OF CELL SCIENCE

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis

(2011) Yi-Ping Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt activation is implicated in glioblastoma radioresistance

(2011) Yonghyun Kim et al.   LABORATORY INVESTIGATION

Radioresistance of glioma stem cells: Intrinsic characteristic or property of the ‘microenvironment-stem cell unit’?

(2011) Mariella Mannino et al.   Molecular Oncology

In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

(2011) Vladimír Mlynárik et al.   NMR IN BIOMEDICINE

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survivin inhibition and DNA double-strand break repair: A molecular mechanism to overcome radioresistance in glioblastoma

(2011) Sebastian Reichert et al.   RADIOTHERAPY AND ONCOLOGY

Potential therapeutic implications of cancer stem cells in glioblastoma

(2010) Lin Cheng et al.   BIOCHEMICAL PHARMACOLOGY

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells

(2010) B. Campos et al.   CLINICAL CANCER RESEARCH

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

Treatment and management of malignant gliomas

(2010) Deric M. Park et al.   Nature Reviews Clinical Oncology

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures

(2010) A Ernst et al.   ONCOGENE

Mitochondrial DNA Integrity Is Essential For Mitochondrial Maturation During Differentiation of Neural Stem Cells

(2010) Wei Wang et al.   STEM CELLS

A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties

(2009) Aurélie Tchoghandjian et al.   BRAIN PATHOLOGY

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Survivin: A new target for anti-cancer therapy

(2009) Bríd M. Ryan et al.   CANCER TREATMENT REVIEWS

Brain tumor treatment increases the number of cancer stem-like cells

(2009) Nikki Charles et al.   Expert Review of Neurotherapeutics

Gli1 is a potential target for alleviating multidrug resistance of gliomas

(2009) Daming Cui et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

αvβ3 and αvβ5 integrins control glioma cell response to ionising radiation through ILK and RhoB

(2008) Sylvie Monferran et al.   INTERNATIONAL JOURNAL OF CANCER

Kaempferol Induces Cell Death Through ERK and Akt-Dependent Down-Regulation of XIAP and Survivin in Human Glioma Cells

(2008) Ji Cheon Jeong et al.   NEUROCHEMICAL RESEARCH

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

(2008) Christine E. Eyler et al.   STEM CELLS

Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells

(2007) P. B Dirks   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES