EGFRAmplification and Glioblastoma Stem-Like Cells

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma

(2015) Nadja Müller et al.   JOURNAL OF IMMUNOTHERAPY

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

(2015) J. Schuster et al.   NEURO-ONCOLOGY

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

(2015) Paul A. Clark et al.   NEOPLASIA

Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay

(2014) Kelly M. MacArthur et al.   CANCER RESEARCH

Glioma stem cells: turpis omen in nomen? (the evil in the name?)

(2014) E. Binda et al.   JOURNAL OF INTERNAL MEDICINE

The Effects of Histone Deacetylase Inhibitors on Glioblastoma-Derived Stem Cells

(2014) Angel A. Alvarez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ABC transporters as differentiation markers in glioblastoma cells

(2014) Ana R. Rama et al.   MOLECULAR BIOLOGY REPORTS

EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

(2014) Hongsheng Miao et al.   PLoS One

Hematogenous dissemination of glioblastoma multiforme

(2014) C. Muller et al.   Science Translational Medicine

Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1

(2014) Eun-Jung Kim et al.   TUMOR BIOLOGY

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients

(2014) Byung Ho Kong et al.   Stem Cells International

A mesenchymal glioma stem cell profile is related to clinical outcome

(2014) A Balbous et al.   Oncogenesis

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis

(2013) Krishna M. Talasila et al.   ACTA NEUROPATHOLOGICA

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

(2013) Annegret Kathagen et al.   ACTA NEUROPATHOLOGICA

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells

(2013) Anna Golebiewska et al.   BRAIN

Differentiation of glioblastoma multiforme stem-like cells leads to downregulation of EGFR and EGFRvIII and decreased tumorigenic and stem-like cell potential

(2013) Marie-Thérése Stockhausen et al.   CANCER BIOLOGY & THERAPY

Specific Elimination of CD133+ Tumor Cells with Targeted Oncolytic Measles Virus

(2013) P. Bach et al.   CANCER RESEARCH

Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III

(2013) D. R. Emlet et al.   CANCER RESEARCH

Targeting Cancer Stem Cells for Treatment of Glioblastoma Multiforme

(2013) Der-Yang Cho et al.   CELL TRANSPLANTATION

EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

(2013) J. H. Sampson et al.   CLINICAL CANCER RESEARCH

Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

(2013) Bryan D. Choi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

(2013) Yasufumi Katanasaka et al.   Molecular Cancer

Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110 

(2013) A. Schulte et al.   NEURO-ONCOLOGY

HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade

(2013) Y J Kim et al.   ONCOGENE

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF

(2013) Neza Podergajs et al.   Radiology and Oncology

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

(2013) David A. Nathanson et al.   SCIENCE

Glioblastoma Stem-like Cell Lines with Either Maintenance or Loss of High-Level EGFR Amplification, Generated via Modulation of Ligand Concentration

(2012) A. Schulte et al.   CLINICAL CANCER RESEARCH

Epidermal growth factor receptor

(2012) Monika E. Hegi et al.   CURRENT OPINION IN NEUROLOGY

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures

(2012) Sandrine Eimer et al.   NEURO-ONCOLOGY

EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms

(2012) C A Del Vecchio et al.   ONCOGENE

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme

(2011) Marie-Thérése Stockhausen et al.   EXPERIMENTAL CELL RESEARCH

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

(2011) Monica Venere et al.   GLIA

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target

(2011) Alexander Schulte et al.   GLIA

The origins of glioma: E Pluribus Unum?

(2011) F. A. Siebzehnrubl et al.   GLIA

Metastatic glioblastoma: case presentations and a review of the literature

(2011) Gauri Kalokhe et al.   JOURNAL OF NEURO-ONCOLOGY

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

(2011) Manfred Westphal et al.   NATURE REVIEWS NEUROSCIENCE

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

A reproducible brain tumour model established from human glioblastoma biopsies

(2010) Jian Wang et al.   BMC CANCER

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(2010) Ruihuan Chen et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Cetuximab Insufficiently Inhibits Glioma Cell Growth Due to Persistent EGFR Downstream Signaling

(2010) Benedikte Hasselbalch et al.   CANCER INVESTIGATION

Epidermal Growth Factor Receptor Expression Identifies Functionally and Molecularly Distinct Tumor-Initiating Cells in Human Glioblastoma Multiforme and Is Required for Gliomagenesis

(2010) S. Mazzoleni et al.   CANCER RESEARCH

Retrovirally engineered T-cell-based immunotherapy targeting type III variant epidermal growth factor receptor, a glioma-associated antigen

(2010) Masasuke Ohno et al.   CANCER SCIENCE

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells

(2010) B. Campos et al.   CLINICAL CANCER RESEARCH

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Insight into the complex regulation of CD133 in glioma

(2010) Benito Campos et al.   INTERNATIONAL JOURNAL OF CANCER

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies

(2010) Monika Witusik-Perkowska et al.   JOURNAL OF NEURO-ONCOLOGY

The Side Population of Gliomas Exhibits Decreased Cell Migration

(2010) Kathrin Weber et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression

(2010) Samuel Beck et al.   MOLECULES AND CELLS

Side Population is Not Necessary or Sufficient for a Cancer Stem Cell Phenotype in Glioblastoma Multiforme

(2010) Kate W. R. Broadley et al.   STEM CELLS

Glioma stem cells as a target for treatment

(2010) Katrin Lamszus et al.   Targeted Oncology

Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-1

(2009) Raita Fukaya et al.   CANCER LETTERS

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Genomic and Expression Profiling of Glioblastoma Stem Cell-Like Spheroid Cultures Identifies Novel Tumor-Relevant Genes Associated with Survival

(2009) A. Ernst et al.   CLINICAL CANCER RESEARCH

Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034

(2009) Martin J. van den Bent et al.   JOURNAL OF CLINICAL ONCOLOGY

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

(2009) Angel Ayuso-Sacido et al.   JOURNAL OF NEURO-ONCOLOGY

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

(2009) Dan R. Laks et al.   STEM CELLS

Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens

(2009) John J. P. Kelly et al.   STEM CELLS

Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

(2008) M. A. Harris et al.   CANCER RESEARCH

Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2

(2008) T. Martens et al.   CLINICAL CANCER RESEARCH

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

(2008) Talal M. Fael Al-Mayhani et al.   JOURNAL OF NEUROSCIENCE METHODS

A COMPARISON BETWEEN STEM CELLS FROM THE ADULT HUMAN BRAIN AND FROM BRAIN TUMORS

(2008) Mercy Varghese et al.   NEUROSURGERY

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

(2008) Corinne E. Griguer et al.   PLoS One