The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumorsin vivo

(2016) Gordon Moody et al.   INTERNATIONAL JOURNAL OF CANCER

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles

(2016) Kaisa E. Happonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer

(2016) C-W Chien et al.   ONCOGENE

The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity

(2016) P. Y. Chan et al.   SCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

(2016) M. A. Miller et al.   Cancer Discovery

The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma

(2016) Min-Shu Hsieh et al.   Oncotarget

TAM receptors Tyro3 and Mer as novel targets in colorectal cancer

(2016) Robin Schmitz et al.   Oncotarget

Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Behçet’s disease

(2016) Jieying Qin et al.   Scientific Reports

AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

(2016) Edward T Schmid et al.   eLife

Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression

(2016) Katsuaki Sato et al.   PLoS One

Axl Expression Stratifies Patients with Poor Prognosis after Hepatectomy for Hepatocellular Carcinoma

(2016) Jian Liu et al.   PLoS One

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

(2015) Amanda Kirane et al.   CANCER RESEARCH

State-of-the-art of small molecule inhibitors of the TAM family: The point of view of the chemist

(2015) Tom Baladi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Incomplete clearance of apoptotic cells in systemic lupus erythematosus: pathogenic role and potential biomarker

(2015) Ju-Yang Jung et al.   International Journal of Rheumatic Diseases

The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome

(2015) Baodong Qin et al.   JOINT BONE SPINE

TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages

(2015) Shasha Zheng et al.   JOURNAL OF IMMUNOLOGY

MERTK as negative regulator of human T cell activation

(2015) Raquel Cabezo´n et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective

(2015) Samuel H. Myers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung

(2015) T Fujimori et al.   Mucosal Immunology

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

(2015) Jonathan J Miner et al.   NATURE MEDICINE

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

TAMing resistance to multi-targeted kinase inhibitors through Axl and Met inhibition

(2015) D J Pinato et al.   ONCOGENE

Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in Juvenile-onset Systemic Lupus Erythematosus

(2015) Lucy Ballantine et al.   Pediatric Rheumatology

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

(2015) Mikaella Vouri et al.   Oncotarget

AXL kinase as a novel target for cancer therapy

(2015) Xiaoliang Wu et al.   Oncotarget

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme

(2015) Kristina H. Knubel et al.   Oncotarget

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

(2015) Yusuke Shiozawa et al.   NEOPLASIA

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

(2014) S. Krause et al.   BLOOD

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

(2014) J. H. M. van der Meer et al.   BLOOD

Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated Cancer

(2014) Carla V. Rothlin et al.   INFLAMMATORY BOWEL DISEASES

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells

(2014) YOUNG-AH SUH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Auto-Oxidation and Oligomerization of Protein S on the Apoptotic Cell Surface Is Required for Mer Tyrosine Kinase-Mediated Phagocytosis of Apoptotic Cells

(2014) H. Uehara et al.   JOURNAL OF IMMUNOLOGY

Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma

(2014) J S Waizenegger et al.   LEUKEMIA

Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus

(2014) H Zhu et al.   LUPUS

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation

(2014) Rui Ji et al.   PLoS One

Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy

(2014) Brendan A Hilliard et al.   ARTHRITIS RESEARCH & THERAPY

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines

(2013) Stephen J. Demarest et al.   BIOCHEMISTRY

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

(2013) I. Ben-Batalla et al.   BLOOD

Inhibitory role of Gas6 in intestinal tumorigenesis

(2013) Reiko Akitake-Kawano et al.   CARCINOGENESIS

Pathogens Use Structural Mimicry of Native Host Ligands as a Mechanism for Host Receptor Engagement

(2013) Nir Drayman et al.   Cell Host & Microbe

Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors

(2013) Suchita Bhattacharyya et al.   Cell Host & Microbe

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

New aminopyrimidine derivatives as inhibitors of the TAM family

(2013) Ténin Traoré et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

(2013) Eugenio A. Carrera Silva et al.   IMMUNITY

Breakdown of immune homeostasis in the testis of mice lacking Tyro3, Axl and Mer receptor tyrosine kinases

(2013) Yue Zhang et al.   IMMUNOLOGY AND CELL BIOLOGY

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

The expression of TAM receptors and their ligand Gas6 is downregulated in psoriasis

(2013) András Szász et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Prolonged Apoptotic Cell Accumulation in Germinal Centers of Mer-Deficient Mice Causes Elevated B Cell and CD4+ Th Cell Responses Leading to Autoantibody Production

(2013) T. N. Khan et al.   JOURNAL OF IMMUNOLOGY

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

(2013) S P Whitman et al.   LEUKEMIA

First Axl inhibitor enters clinical trials

(2013) Cormac Sheridan   NATURE BIOTECHNOLOGY

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Development of a Spontaneous Liver Disease Resembling Autoimmune Hepatitis in Mice Lacking Tyro3, Axl and Mer Receptor Tyrosine Kinases

(2013) Nan Qi et al.   PLoS One

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

(2013) L. Bosurgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

(2013) Pedro Recarte-Pelz et al.   ARTHRITIS RESEARCH & THERAPY

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

(2012) B. T. van den Brand et al.   ARTHRITIS AND RHEUMATISM

The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry

(2012) Laurent Meertens et al.   Cell Host & Microbe

Cancer risk in long-term users of vitamin K antagonists: A population-based case-control study

(2012) Anton Pottegård et al.   INTERNATIONAL JOURNAL OF CANCER

Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl in patients with Systemic lupus erythematosus and Behçets disease

(2012) Tamer A. Gheita et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells

(2012) Hyun-Jung Park et al.   MOLECULAR BIOLOGY OF THE CELL

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Novel and selective spiroindoline-based inhibitors of sky kinase

(2011) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation

(2011) Melissa Sandahl et al.   BMC DEVELOPMENTAL BIOLOGY

Viral Apoptotic Mimicry Party: P.S. Bring Your Own Gas6

(2011) Jason Mercer   Cell Host & Microbe

The growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G>A is associated with type 2 diabetes

(2011) Chien-Hsing Lee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 is a new MerTK-specific eat-me signal

(2011) Nora B. Caberoy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

(2011) Jason G Weinger et al.   Journal of Neuroinflammation

Targeting Axl and Mer Kinases in Cancer

(2011) A. Verma et al.   MOLECULAR CANCER THERAPEUTICS

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

(2011) Jun Wu et al.   ARTHRITIS RESEARCH & THERAPY

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Long-term use of vitamin K antagonists and incidence of cancer: a population-based study

(2010) V. Pengo et al.   BLOOD

Natural anticoagulant protein levels in Turkish patients with inflammatory bowel disease

(2010) Basak Cakal et al.   BLOOD COAGULATION & FIBRINOLYSIS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

Sertoli Cell-Initiated Testicular Innate Immune Response through Toll-Like Receptor-3 Activation Is Negatively Regulated by Tyro3, Axl, and Mer Receptors

(2010) Bing Sun et al.   ENDOCRINOLOGY

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

GAS6 Enhances Repair Following Cuprizone-Induced Demyelination

(2010) Vladislav Tsiperson et al.   PLoS One

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells

(2009) Wen-Hai Shao et al.   CLINICAL IMMUNOLOGY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

(2009) Tal Burstyn-Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Survival and Migration of Human Dendritic Cells Are Regulated by an IFN- -Inducible Axl/Gas6 Pathway

(2009) S. Scutera et al.   JOURNAL OF IMMUNOLOGY

Immune Therapy for Cancer

(2008) Michael Dougan et al.   Annual Review of Immunology

Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages

(2008) D. Liao et al.   BLOOD

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

(2008) I.-K. Park et al.   BLOOD

Negative signaling by inhibitory receptors: the NK cell paradigm

(2008) Eric O. Long   IMMUNOLOGICAL REVIEWS

Role of Gas6 in erythropoiesis and anemia in mice

(2008) Anne Angelillo-Scherrer et al.   JOURNAL OF CLINICAL INVESTIGATION

MerTK is required for apoptotic cell–induced T cell tolerance

(2008) Mark A. Wallet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells

(2007) Weipeng Xiong et al.   REPRODUCTION