Incomplete clearance of apoptotic cells in systemic lupus erythematosus: pathogenic role and potential biomarker

Role of Apoptosis in disease

(2016) B. Favaloro et al.   Aging-US

Autoantibodies to C-Reactive Protein in Incomplete Lupus and Systemic Lupus Erythematosus

(2015) Ju-Yang Jung et al.   JOURNAL OF INVESTIGATIVE MEDICINE

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

(2014) Manikandan Subramanian et al.   JOURNAL OF CLINICAL INVESTIGATION

Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus

(2014) H Zhu et al.   LUPUS

Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets

(2014) N Yamamoto et al.   LUPUS

Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages

(2014) C. Nishi et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy

(2014) Brendan A Hilliard et al.   ARTHRITIS RESEARCH & THERAPY

Association of Serum C-Reactive Protein Levels With Lupus Disease Activity in the Absence of Measurable Interferon-α and a C-Reactive Protein Gene Variant

(2014) Helena Enocsson et al.   Arthritis & Rheumatology

C-Reactive Protein Inhibits Plasmacytoid Dendritic Cell Interferon Responses to Autoantibody Immune Complexes

(2013) Carolyn Mold et al.   ARTHRITIS AND RHEUMATISM

TAM receptors in apoptotic cell clearance, autoimmunity, and cancer

(2013) Khanh-Quynh Nguyen et al.   AUTOIMMUNITY

Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) on kidney tissue from systemic lupus erythematosus (SLE) patients

(2013) Ling Guo et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer

(2013) Lutfi Suleiman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Prolonged Apoptotic Cell Accumulation in Germinal Centers of Mer-Deficient Mice Causes Elevated B Cell and CD4+ Th Cell Responses Leading to Autoantibody Production

(2013) T. N. Khan et al.   JOURNAL OF IMMUNOLOGY

Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

(2013) G Majai et al.   LUPUS

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

(2013) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis

(2013) Chien-Sheng Wu et al.   RHEUMATOLOGY INTERNATIONAL

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

(2013) Pedro Recarte-Pelz et al.   ARTHRITIS RESEARCH & THERAPY

Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

(2013) Gaetano Zizzo et al.   ARTHRITIS RESEARCH & THERAPY

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

Serum Growth Arrest-Specific Protein 6 Levels are a Reliable Biomarker of Disease Activity in Systemic Lupus Erythematosus

(2012) Hyoun-Ah Kim et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl in patients with Systemic lupus erythematosus and Behçets disease

(2012) Tamer A. Gheita et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Complement Component C1q Regulates Macrophage Expression of Mer Tyrosine Kinase To Promote Clearance of Apoptotic Cells

(2012) M. D. Galvan et al.   JOURNAL OF IMMUNOLOGY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

C-reactive Protein Is a More Sensitive and Specific Marker for Diagnosing Bacterial Infections in Systemic Lupus Erythematosus Compared to S100A8/A9 and Procalcitonin

(2012) H.-A. KIM et al.   JOURNAL OF RHEUMATOLOGY

Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation

(2011) Monowar Aziz et al.   APOPTOSIS

Autoimmunity in MFG-E8–deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens

(2011) YuFeng Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases

(2011) Madhu Ramaswamy et al.   Nature Reviews Rheumatology

Amelioration of Lupus Nephritis by Serum Amyloid P Component Gene Therapy with Distinct Mechanisms Varied from Different Stage of the Disease

(2011) Weijuan Zhang et al.   PLoS One

Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus

(2011) C. Ekman et al.   RHEUMATOLOGY

Disturbances of apoptotic cell clearance in systemic lupus erythematosus

(2011) Wen-Hai Shao et al.   ARTHRITIS RESEARCH & THERAPY

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

(2011) Jun Wu et al.   ARTHRITIS RESEARCH & THERAPY

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosus

(2010) Sean G. O'Neill et al.   ARTHRITIS AND RHEUMATISM

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus

(2010) Peiqing Zhao et al.   Cellular & Molecular Immunology

TAM receptor signaling and autoimmune disease

(2010) Carla V Rothlin et al.   CURRENT OPINION IN IMMUNOLOGY

Impaired Apoptotic Cell Clearance in the Germinal Center by Mer-Deficient Tingible Body Macrophages Leads to Enhanced Antibody-Forming Cell and Germinal Center Responses

(2010) Z. S. M. Rahman et al.   JOURNAL OF IMMUNOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

(2010) R. Rodriguez-Manzanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

(2010) Chang-Hee Suh et al.   ARTHRITIS RESEARCH & THERAPY

The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF

(2009) P. R. Gohlke et al.   AUTOIMMUNITY

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

(2009) M. Nakayama et al.   BLOOD

C-Reactive Protein Gene Polymorphisms in Disease Susceptibility and Clinical Manifestations of Korean Systemic Lupus Erythematosus

(2009) H.-A. KIM et al.   JOURNAL OF RHEUMATOLOGY

Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human

(2009) CY Hu et al.   LUPUS

Major cell death pathways at a glance

(2009) Linde Duprez et al.   MICROBES AND INFECTION

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE)

(2008) C. Janko et al.   AUTOIMMUNITY REVIEWS

Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up?

(2008) Donna L. Bratton et al.   CURRENT BIOLOGY

Pattern recognition receptors in the immune response against dying cells

(2008) Pascale Jeannin et al.   CURRENT OPINION IN IMMUNOLOGY

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus

(2008) Hiroshi Yamaguchi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Apoptosis in the pathogenesis of systemic lupus erythematosus

(2008) LE Munoz et al.   LUPUS

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark