Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells

(2014) G. F. Torelli et al.   HAEMATOLOGICA

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

(2014) Andrew Volk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

(2013) I. Ben-Batalla et al.   BLOOD

Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia

(2013) R. M. A. Linger et al.   BLOOD

DeregulatedMIR335that targetsMAPK1is implicated in poor outcome of paediatric acute lymphoblastic leukaemia

(2013) Junli Yan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Wnt pathway contributes to the protection by bone marrow stromal cells of acute lymphoblastic leukemia cells and is a potential therapeutic target

(2013) Yang Yang et al.   CANCER LETTERS

Molecular Pathways: MERTK Signaling in Cancer

(2013) C. T. Cummings et al.   CLINICAL CANCER RESEARCH

UNC1062, a new and potent Mer inhibitor

(2013) Jing Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Second Malignant Neoplasms After Treatment of Childhood Acute Lymphoblastic Leukemia

(2013) Kjeld Schmiegelow et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

(2013) Weihe Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic LeukemiaIn VitroandIn Vivo

(2013) Sandra Christoph et al.   MOLECULAR CANCER THERAPEUTICS

Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia

(2013) A B Lee-Sherick et al.   ONCOGENE

Temporal Lobe Epilepsy With Hippocampal Sclerosis in Acute Lymphoblastic Leukemia

(2013) E. Kasai-Yoshida et al.   PEDIATRICS

In Vivo Imaging Enables High Resolution Preclinical Trials on Patients’ Leukemia Cells Growing in Mice

(2013) Nadia Terziyska et al.   PLoS One

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme

(2012) Y Wang et al.   ONCOGENE

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment

(2011) M. Schmitz et al.   BLOOD

p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells

(2011) Shivashni S. Gaundar et al.   CELL CYCLE

Macrophage–tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands

(2011) Thomas Schmidt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

(2011) Saran Feng et al.   PLoS One

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

(2010) A. K. Ghosh et al.   BLOOD

Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers

(2010) S. Pillozzi et al.   BLOOD

The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia

(2010) P. Saunders et al.   HAEMATOLOGICA

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

(2010) Laura Bonapace et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

Central nervous system (CNS)–resident natural killer cells suppress Th17 responses and CNS autoimmune pathology

(2010) Junwei Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia

(2009) R. Crazzolara et al.   BLOOD

CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK

(2009) Julius G. Juarez et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells

(2009) Wen-Hai Shao et al.   CLINICAL IMMUNOLOGY

Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen

(2009) E. Lierman et al.   HAEMATOLOGICA

High Erk-1 activation and Gadd45a expression as prognostic markers in high risk pediatric haemolymphoproliferative diseases

(2009) Velia D'Angelo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1

(2009) S Jeha et al.   LEUKEMIA

Central Nervous System Disease in Hematologic Malignancies: Historical Perspective and Practical Applications

(2009) Ching-Hon Pui et al.   SEMINARS IN ONCOLOGY

Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95

(2008) A. Moricke et al.   BLOOD

Current management and challenges of malignant disease in the CNS in paediatric leukaemia

(2008) Ching-Hon Pui et al.   LANCET ONCOLOGY

ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

(2008) D. M. Schewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA