A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5

(2016) Huan-Tian Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Walking the tightrope: proteostasis and neurodegenerative disease

(2016) Justin J. Yerbury et al.   JOURNAL OF NEUROCHEMISTRY

CHIP: A new modulator of human malignant disorders

(2016) Zhe Cao et al.   Oncotarget

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

(2016) Antonio Currais et al.   Aging-US

Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing

(2015) Arun Upadhyay et al.   AGEING RESEARCH REVIEWS

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling

(2015) Amy M. Palubinsky et al.   ANTIOXIDANTS & REDOX SIGNALING

UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP

(2015) Yanfen Teng et al.   BIOCHEMICAL PHARMACOLOGY

Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death

(2015) C Kim et al.   CELL DEATH AND DIFFERENTIATION

CHIP Knockdown Reduced Heat Shock Response and Protein Quality Control Capacity in Lens Epithelial Cells

(2015) W. Zhang et al.   CURRENT MOLECULAR MEDICINE

A CHIPotle in physiology and disease

(2015) Indranil Paul et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP

(2015) Sarah E. Soss et al.   PLoS One

CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system

(2015) Felipe Cabral Miranda et al.   Frontiers in Cellular Neuroscience

An acetylation switch controls TDP-43 function and aggregation propensity

(2015) Todd J. Cohen et al.   Nature Communications

Regulation of autophagic flux by CHIP

(2015) Dongkai Guo et al.   Neuroscience Bulletin

C-terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration

(2014) Ye Na Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1

(2014) Yu Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway

(2014) Xu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging therapies targeting the ubiquitin proteasome system in cancer

(2014) Nathaniel M. Weathington et al.   JOURNAL OF CLINICAL INVESTIGATION

The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3

(2014) Natalya A. Blessing et al.   MOLECULAR AND CELLULAR BIOLOGY

STUB1 mutations in autosomal recessive ataxias – evidence for mutation-specific clinical heterogeneity

(2014) Ketil Heimdal et al.   Orphanet Journal of Rare Diseases

Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia

(2014) Maria Jose Casarejos et al.   PLoS One

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

(2014) H.-E. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation

(2013) Qin Wei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metastatic Lymph Node CHIP Expression is a Potential Prognostic Marker for Resected Esophageal Squamous Cell Carcinoma Patients

(2013) Jing Wen et al.   ANNALS OF SURGICAL ONCOLOGY

Genetic Screening for Mutations in the Chip Gene in Intracranial Aneurysm Patients of Chinese Han Nationality

(2013) Li Su et al.   Asian Pacific Journal of Cancer Prevention

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

C-terminus of Hsc70-interacting protein regulates C-terminal binding protein 2 and the expression of its target genes

(2013) Ji Sun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

(2013) Michael H. Tatham et al.   BIOCHEMICAL JOURNAL

Selective Autophagy: Talking with the UPS

(2013) Caroline Park et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

STUB1 is essential for T-cell activation by ubiquitinating CARMA1

(2013) Shuai Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting the ubiquitin–proteasome system for cancer therapy

(2013) Min Shen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP

(2013) Chang-He Shi et al.   HUMAN MOLECULAR GENETICS

Multimeric Growth Hormone Receptor Complexes Serve as Signaling Platforms

(2013) Magdalena Sedek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination Regulates the Neuroprotective Function of the Deubiquitinase Ataxin-3in Vivo

(2013) Wei-Ling Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation

(2013) Gnana Prakasam Krishnamoorthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis

(2013) Chao Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Inhibition of Histone Deacetylase Activity Suppresses IFN-  Induction of Tripartite Motif 22 via CHIP-Mediated Proteasomal Degradation of IRF-1

(2013) B. Gao et al.   JOURNAL OF IMMUNOLOGY

USP47 and C Terminus of Hsp70-Interacting Protein (CHIP) Antagonistically Regulate Katanin-p60-Mediated Axonal Growth

(2013) S. W. Yang et al.   JOURNAL OF NEUROSCIENCE

The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination

(2013) Sarah M. Ronnebaum et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of CHIP as a Novel Causative Gene for Autosomal Recessive Cerebellar Ataxia

(2013) Yuting Shi et al.   PLoS One

CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G

(2013) J S Lee et al.   Cell Death & Disease

Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model

(2013) Xiao-rui Cheng et al.   Frontiers in Aging Neuroscience

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

(2012) Shin-Ae Kang et al.   BIOCHEMICAL JOURNAL

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

(2012) Shouyu Wang et al.   GUT

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

(2012) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Ubc13 and COOH Terminus of Hsp70-interacting Protein (CHIP) Are Required for Growth Hormone Receptor Endocytosis

(2012) Johan A. Slotman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Carboxy terminus of heat shock protein (HSP) 70-interacting protein (CHIP) inhibits HSP70 in the heart

(2012) Bijun Zhao et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Misfolded Proteins Recognition Strategies of E3 Ubiquitin Ligases and Neurodegenerative Diseases

(2012) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Chaperones in autophagy

(2012) Susmita Kaushik et al.   PHARMACOLOGICAL RESEARCH

Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments

(2012) BethAnn McLaughlin et al.   PLoS One

HSP90 inhibitor antagonizing MIF

(2012) Ramona Schulz et al.   OncoImmunology

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4

(2011) Song Chen et al.   AGE

Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation

(2011) Qingshan Wang et al.   BIOCHEMICAL PHARMACOLOGY

Quality control and fate determination of Hsp90 client proteins

(2011) Maria A. Theodoraki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CHIP and gp78-mediated ubiquitination of CYP3A4

(2011) Cody J. Peer et al.   CANCER BIOLOGY & THERAPY

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

(2011) K H Oh et al.   CELL DEATH AND DIFFERENTIATION

E3 Ligase STUB1/CHIP Regulates NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Accumulation in Aged Brain, a Process Impaired in Certain Alzheimer Disease Patients

(2011) Peter Tsvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2 Conjugating Enzyme Selectivity and Requirements for Function of the E3 Ubiquitin Ligase CHIP

(2011) Sarah E. Soss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malin and laforin are essential components of a protein complex that protects cells from thermal stress

(2011) S. Sengupta et al.   JOURNAL OF CELL SCIENCE

Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion

(2011) Kang Won Jang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

(2011) Martin Gamerdinger et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders

(2011) Pravir Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients

(2011) Chia-Ing Jan et al.   JOURNAL OF PATHOLOGY

Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination

(2011) YongQiang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

(2011) H Gaude et al.   ONCOGENE

Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

(2011) Lorraine V. Kalia et al.   PLoS One

C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-  and the critical period hypothesis of estrogen neuroprotection

(2011) Q.-g. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-Terminus of Heat Shock Protein 70–Interacting Protein–Dependent GTP Cyclohydrolase I Degradation in Lambs with Increased Pulmonary Blood Flow

(2010) Xutong Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CHIP promotes the degradation of mutant SOD1 by reducing its interaction with VCP and S6/S6′ subunits of 26S proteasome

(2010) Jin-Sun Choi et al.   Animal Cells and Systems

Insights into the Conformational Dynamics of the E3 Ubiquitin Ligase CHIP in Complex with Chaperones and E2 Enzymes

(2010) Christian Graf et al.   BIOCHEMISTRY

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Bag1 directly routes immature BCR-ABL for proteasomal degradation

(2010) F. Tsukahara et al.   BLOOD

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

(2010) Takeshi Maruyama et al.   EMBO JOURNAL

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

(2010) Chang-Hoon Woo et al.   FASEB JOURNAL

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

(2010) Stefanie Löffek et al.   HUMAN MUTATION

CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity

(2010) Ji Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking-dependent Ubiquitination of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by the Ubiquitin Ligase CHIP

(2010) Vikram Narayan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP

(2010) Jia Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CHIP functions an E3 ubiquitin ligase of Runx1

(2009) Yu Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic strategies within the ubiquitin proteasome system

(2009) A G Eldridge et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Co-chaperone CHIP Stabilizes Aggregate-prone Malin, a Ubiquitin Ligase Mutated in Lafora Disease

(2009) Sudheendra N. R. Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1

(2009) Fang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP

(2009) Lenka Kundrat et al.   JOURNAL OF MOLECULAR BIOLOGY

CHIP Represses Myocardin-Induced Smooth Muscle Cell Differentiation via Ubiquitin-Mediated Proteasomal Degradation

(2009) P. Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP

(2009) Xiaodong Ding et al.   PLoS One

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

(2009) Han Seok Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

(2008) Mark Windheim et al.   BIOCHEMICAL JOURNAL

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

(2008) Xueni Li et al.   JOURNAL OF CELL BIOLOGY

Chaperone signalling complexes in Alzheimer's disease

(2008) John Koren et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quercetin-induced ubiquitination and down-regulation of Her-2/neu

(2008) Jae-Hoon Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

CHIPping Away at Base Excision Repair

(2008) Robert W. Sobol   MOLECULAR CELL

CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins

(2008) Jason L. Parsons et al.   MOLECULAR CELL

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(2008) G Irvine et al.   MOLECULAR MEDICINE

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

(2008) Aislinn J. Williams et al.   NEUROBIOLOGY OF DISEASE

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

(2008) Zhen Xu et al.   BMC STRUCTURAL BIOLOGY

MKKS Is a Centrosome-shuttling Protein Degraded by Disease-causing Mutations via CHIP-mediated Ubiquitination

(2007) Shoshiro Hirayama et al.   MOLECULAR BIOLOGY OF THE CELL