Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders

Park2-Null/Tau Transgenic Mice Reveal a Functional Relationship between Parkin and Tau

(2017) Rosa Guerrero et al.   JOURNAL OF ALZHEIMERS DISEASE

Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?

(2017) Noriyuki Matsuda et al.   JOURNAL OF ALZHEIMERS DISEASE

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

(2017) Renato X. Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Unraveling the Complexity of Amyotrophic Lateral Sclerosis: Recent Advances from the Transgenic Mutant SOD1 Mice

(2012) M. Peviani et al.   CNS & Neurological Disorders-Drug Targets

Regulation of PINK1-Parkin-mediated mitophagy

(2011) Wolfdieter Springer et al.   Autophagy

The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration: Table 1

(2011) Jonathan Janssens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Unexpected link between anaphase promoting complex and the toxicity of expanded polyglutamines expressed in yeast

(2011) Natalia A. Bocharova et al.   CELL CYCLE

The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

(2011) Selvaraju Veeriah et al.   CELL CYCLE

FTD and ALS: A Tale of Two Diseases

(2011) R. Ferrari et al.   Current Alzheimer Research

The role of the ubiquitin proteasome system in Alzheimer's disease

(2011) Beat M Riederer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

E3 Ligase STUB1/CHIP Regulates NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Accumulation in Aged Brain, a Process Impaired in Certain Alzheimer Disease Patients

(2011) Peter Tsvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation

(2011) Silvia Zucchelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin

(2011) Jennifer L. Illuzzi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice

(2011) Thibault Ganay et al.   Molecular Neurodegeneration

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function

(2010) Bing Gong et al.   AGING CELL

Targeting amyloid precursor protein

(2010) Guido Hermey   ANNALS OF NEUROLOGY

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

(2010) Lih-Shen Chin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease

(2010) Ashok N. Hegde et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant

(2010) Alessia Bellomaria et al.   CELL CYCLE

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Towards the Treatment of Polyglutamine Diseases: The Modulatory Role of Protein Context

(2010) A. L. Robertson et al.   CURRENT MEDICINAL CHEMISTRY

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

Parkinson's disease: insights from pathways

(2010) M. R. Cookson et al.   HUMAN MOLECULAR GENETICS

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice

(2010) Lin Zhang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

(2010) Y.-Y. Park et al.   JOURNAL OF CELL SCIENCE

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Parkin Directly Modulates 26S Proteasome Activity

(2010) J. W. Um et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production

(2010) Ryo Saito et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration

(2010) Tomohiro Nakamura et al.   MITOCHONDRION

GSK3 and p53 - is there a link in Alzheimer's disease?

(2010) Carole J Proctor et al.   Molecular Neurodegeneration

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies

(2010) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

Proteasomal dysfunction in aging and Huntington disease

(2010) Xiao-Jiang Li et al.   NEUROBIOLOGY OF DISEASE

Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease

(2010) Jiaming Mei et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP

(2010) Hui Yang et al.   PLoS One

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

The relationship between parkin and protein aggregation in neurodegenerative diseases

(2010) Preeti Khandelwal   Frontiers in Psychiatry

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

(2009) Pamela J. Plant et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice

(2009) Juan Perucho et al.   EXPERIMENTAL NEUROLOGY

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

A Sporadic Parkinson Disease Model via Silencing of the Ubiquitin-Proteasome/E3 Ligase Component SKP1A

(2009) Tali Fishman-Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution

(2009) Kamila Sroka et al.   JOURNAL OF NEUROCHEMISTRY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis

(2009) Jun Sone et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

(2009) Cristine Alves da Costa et al.   NATURE CELL BIOLOGY

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia

(2009) M. A. Burack et al.   NEUROLOGY

Variation in RTN3 and PPIL2 Genes Does not Influence Platelet Membrane β-Secretase Activity or Susceptibility to Alzheimer’s Disease in the Northern Irish Population

(2009) Robyn Carson et al.   NEUROMOLECULAR MEDICINE

Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population

(2009) Xiaoyun Mo et al.   PARKINSONISM & RELATED DISORDERS

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

(2009) A. H. K. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Progressive Purkinje Cell Degeneration in tambaleante Mutant Mice Is a Consequence of a Missense Mutation in HERC1 E3 Ubiquitin Ligase

(2009) Tomoji Mashimo et al.   PLoS Genetics

Cortical α-synuclein load is associated with amyloid-β plaque burden in a subset of Parkinson’s disease patients

(2008) Tammaryn Lashley et al.   ACTA NEUROPATHOLOGICA

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Increased Aβ1-42 Production Sensitizes Neuroblastoma Cells for ER Stress Toxicity

(2008) Sidhartha Chafekar et al.   Current Alzheimer Research

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

(2008) Carolina Maestre et al.   EMBO JOURNAL

Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?

(2008) Ayse Ulusoy et al.   EXPERIMENTAL NEUROLOGY

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

(2008) Jose A. Rodríguez-Navarro et al.   HUMAN MOLECULAR GENETICS

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis†

(2008) Cristina Cheroni et al.   HUMAN MOLECULAR GENETICS

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

(2008) Y. Morishima et al.   HUMAN MOLECULAR GENETICS

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

(2008) Jianjun Wang et al.   JOURNAL OF CELL BIOLOGY

Parkin Attenuates Wild-Type τ Modification in the Presence of β-Amyloid and α-Synuclein

(2008) Charbel E.-H. Moussa   JOURNAL OF MOLECULAR NEUROSCIENCE

Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats

(2008) Y.-J. Zhang et al.   JOURNAL OF NEURAL TRANSMISSION

Parkin mediates the degradation-independent ubiquitination of Hsp70

(2008) Darren J. Moore et al.   JOURNAL OF NEUROCHEMISTRY

Blocking A 42 Accumulation Delays the Onset and Progression of Tau Pathology via the C Terminus of Heat Shock Protein70-Interacting Protein: A Mechanistic Link between A  and Tau Pathology

(2008) S. Oddo et al.   JOURNAL OF NEUROSCIENCE

A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

(2008) Qing Liu et al.   Molecular Neurodegeneration

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

(2008) Ling-Bo Li et al.   NATURE

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

(2008) Aislinn J. Williams et al.   NEUROBIOLOGY OF DISEASE

Imaging amyloid deposition in Lewy body diseases

(2008) S. N. Gomperts et al.   NEUROLOGY

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

(2008) Furong Yu et al.   NEUROSCIENCE LETTERS

Age-related expression of STUB1 in senescence-accelerated mice and its response to anti-Alzheimer's disease traditional Chinese medicine

(2008) Gui-Rong Zhang et al.   NEUROSCIENCE LETTERS

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43: an emerging new player in neurodegenerative diseases

(2008) I-Fan Wang et al.   TRENDS IN MOLECULAR MEDICINE

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

(2008) Zhen Xu et al.   BMC STRUCTURAL BIOLOGY