Article
Biochemistry & Molecular Biology
Shicong Zhu, Cheng Xing, Guangsen Zhang, Hongling Peng, Zhihua Wang
Summary: In this study, CC1007 was found to inhibit the proliferation of multiple myeloma cells and induce apoptosis and cell cycle arrest. Additionally, CC1007 decreased the expression of MEF2C and HDAC7, disrupting their interaction and promoting the overexpression of Nur77. These findings suggest that CC1007 may be a promising drug for the treatment of multiple myeloma.
BIOORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ting Guo, Shaohua Hu, Weijue Xu, Jin Zhou, Feng Chen, Tingting Gao, Wenqian Qu, Faling Chen, Zhibao Lv, Li Lu
Summary: This study found that histone deacetylase 8 (HDAC8) plays an important role in modulating arginine metabolism during the development of necrotizing enterocolitis (NEC) by regulating the acetylation of histone 3 lysine 9 (acetyl-H3K9). The upregulation of HDAC8 was observed in samples from humans and mice with NEC, and selective inhibition of HDAC8 expression improved NEC. HDAC8 was found to regulate enzymes involved in the metabolic conversion of proline to arginine and arginine to ornithine, and the signal of H3K9ac in the promoter region of PRODH/PRODH2 was mediated by HDAC8. A decreased concentration of butyric acid was correlated with elevated HDAC8 levels and circulating arginine, suggesting an unbalanced Firmicutes/Bacteroidetes ratio.
Article
Multidisciplinary Sciences
Sharath Chandra Gaddelapati, Najla M. Albishi, Ramesh Kumar Dhandapani, Subba Reddy Palli
Summary: This study identified 10 genes coding for HDACs in the yellow fever mosquito and determined their role in larval development using RNA interference. The findings suggest that HDAC3 plays a crucial role in larval development and knockdown of HDAC3 leads to larval death and affects midgut size.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
E. Chen, NanJing Liu, Yan Zhao, Min Tang, LiPing Ou, XiaoHou Wu, ChunLi Luo
Summary: The study found that panobinostat can enhance the acetylation of lys9 of histone 3 and reverse the expression of hepaCAM through inhibiting HDACs activity in PCa LNCaP and DU145 cells. Furthermore, the combination of Ad-hepaCAM with panobinostat synergistically inhibits the growth of LNCaP and DU145 cells, potentially by down-regulating the expression of CCND1 and PCNA.
Article
Ecology
Tae Young Ryu, Kwangho Kim, Tae-Su Han, Mi-Ok Lee, Jinkwon Lee, Jinhyeon Choi, Kwang Bo Jung, Eun-Jeong Jeong, Da Mi An, Cho-Rok Jung, Jung Hwa Lim, Jaeeun Jung, Kunhyang Park, Moo-Seung Lee, Mi-Young Kim, Soo Jin Oh, Keun Hur, Ryuji Hamamoto, Doo-Sang Park, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Summary: The human microbiome has been found to play a crucial role in regulating colorectal cancer growth through the modulation of EHMT2 protein levels and TNFAIP1 gene expression. This study suggests that propionate and EHMT2 inhibitors may serve as therapeutic targets for colon cancer treatment, and there may be synergistic effects between EHMT2 inhibitors and the microbiome in CRC treatment.
Article
Microbiology
Juanbin Yin, Shasha Wang, Shanhui Ren, Zhengji Liang, Junwei Ge, Yuefeng Sun, Xiangping Yin, Xiangwei Wang
Summary: TMP269, a small molecular inhibitor of IIa histone deacetylase, has been found to play a vital role in cancer therapeutic. This study discovered that TMP269 treatment can significantly inhibit the replication of RABV virus without significant cytotoxicity. It was also found that TMP269 can reduce viral titers and protein levels of RABV at an early stage in the viral life cycle. RNA sequencing data revealed that immune-related pathways and autophagy-related genes were downregulated after RABV infection treated with TMP269. Further exploration showed that autophagy enhances RABV replication, while TMP269 can inhibit autophagy to decrease RABV replication. These findings provide a novel treatment strategy for rabies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick Lugenbiel, Katharina Govorov, Pascal Syren, Ann-Kathrin Rahm, Teresa Wieder, Maximilian Wunsch, Nadine Weiberg, Emili Manolova, Dominik Gramlich, Rasmus Rivinius, Daniel Finke, Lorenz H. Lehmann, Patrick A. Schweizer, Derk Frank, Fadwa A. El Tahry, Claus Bruehl, Tanja Heimberger, Steffi Sandke, Tanja Weis, Patrick Most, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Norbert Frey, Hugo A. Katus, Dierk Thomas
Summary: Atrial fibrillation is associated with electrical remodeling, which may be influenced by HDAC2 and NRSF, impacting action potential duration in atrial myocytes through direct regulation of K+ channel expression.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Genetics & Heredity
Nidhal Raheem Juhi Al-Kaabi, Sepideh Chodari Khameneh, Mohadeseh Montazeri, Mahsa Mardasi, Jalal Mosayebi Amroabadi, Fatemeh Sakhaee, Abolfazl Fateh
Summary: The study found a probable relationship between the severity of COVID-19 infection and certain genotypes of TRIM22 SNPs, as well as clinical parameters. Further global research is needed to explore the association between COVID-19 infection severity and host genetic factors.
Article
Veterinary Sciences
Hao An, Yumei Liu, Ming Shu, Junhao Chen
Summary: We report that interleukin-22 (IL-22) activates the phosphorylation of STAT3 to enhance the expression of TRIM25 induced by interferon-gamma (IFN-γ) and provides a defense against duck viral hepatitis A virus type 1 (DHAV-1) by inducing the production of IFNs.
VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur
Summary: Salt Inducible Kinases 2 (SIK2) and 3 (SIK3) play important roles in thymic T cell development, with their loss leading to decreased numbers of peripheral T cells and defects in negative and/or positive selection in the thymus.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Rong Chen, Xiao Han, Hankun Xu, Jidong Xu, Tong Cao, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: The expression of histone deacetylase 1 (HDAC1) is reduced during classical swine fever virus (CSFV) infection, and HDAC1 acts as a negative regulator of CSFV replication by activating specific immune pathways. The N-protein of CSFV interacts with transcriptional regulator Sp1 and promotes its degradation, leading to the downregulation of HDAC1 expression. This study provides insights into the mechanisms by which CSFV evades host innate immune responses.
JOURNAL OF VIROLOGY
(2023)
Article
Oncology
Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang
Summary: Astragaloside IV (ASIV) has been shown to inhibit post-ischemic NK cell brain infiltration and activation, as well as reverse NK cell deficiency in the periphery, contributing to its beneficial effects against brain ischemia. Additionally, ASIV's effects on suppressing NK cell brain infiltration and activation may involve HDAC inhibition.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Yehui Shi, Ying Fu, Xin Zhang, Gang Zhao, Yuan Yao, Yan Guo, Gang Ma, Shuai Bai, Hui Li
Summary: Romidepsin, an HDACi, has anti-tumor effects on colon cancer by upregulating PD-L1 expression, influencing the ratio of T cells, and altering immune responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Hematology
Siyuan Xu, Siqing Wang, Shenghui Xing, Dingdang Yu, Bowen Rong, Hai Gao, Mengyao Sheng, Yun Tan, Xiaojian Sun, Kankan Wang, Kai Xue, Zhennan Shi, Fei Lan
Summary: Epigenetic abnormalities play a critical role in cancer, specifically in diseases like AML where aberrant fusion proteins drive the disease. The loss of KDM5A leads to differentiation and growth retardation in APL NB4 cells, by suppressing the expression of key target genes. Inhibition of KDMSA could greatly enhance differentiation in NB4 cells, suggesting a potential therapeutic target in APL treatment.
Article
Oncology
Rong Liang, Jinyan Zhang, Zhihui Liu, Ziyu Liu, Qian Li, Xiaoling Luo, Yongqiang Li, Jiazhou Ye, Yan Lin
Summary: RBM8A is abnormally overexpressed in hepatocellular carcinoma (HCC) and is involved in the development of drug resistance. It has the ability to regulate tumor-related signaling pathways, particularly through its interaction with histone deacetylase 9 (HDAC9). These findings suggest that RBM8A and its related pathways could serve as potential markers of oxaliplatin resistance and therapeutic targets in HCC.
FRONTIERS IN ONCOLOGY
(2021)