A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

Signals and Sequences That Control CD28 Localization to the Central Region of the Immunological Synapse

(2014) M. Sanchez-Lockhart et al.   JOURNAL OF IMMUNOLOGY

T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase C 

(2014) S.-Y. Tseng et al.   JOURNAL OF IMMUNOLOGY

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

Small Molecule Inhibitors of PKCθ as Potential Antiinflammatory Therapeutics

(2009) Diane Boschelli   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Cellular Context of T Cell Signaling

(2009) Michael L. Dustin   IMMUNITY

Two pathways of costimulation through CD28

(2009) Jim Miller et al.   IMMUNOLOGIC RESEARCH

CD28 and CTLA-4 coreceptor expression and signal transduction

(2009) Christopher E. Rudd et al.   IMMUNOLOGICAL REVIEWS

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

SLAT/Def6 Plays a Critical Role in the Development of Th17 Cell-Mediated Experimental Autoimmune Encephalomyelitis

(2009) A. J. Canonigo-Balancio et al.   JOURNAL OF IMMUNOLOGY

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

(2009) L. F. Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine-Phosphorylation-Dependent Translocation of the SLAT Protein to the Immunological Synapse Is Required for NFAT Transcription Factor Activation

(2008) Stéphane Bécart et al.   IMMUNITY

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY