Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape

Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS

(2016) Chaoran Yin et al.   AIDS

Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy

(2016) Harshana S. De Silva Feelixge et al.   ANTIVIRAL RESEARCH

Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed keratinocytes

(2016) Zhi-Ming Cai et al.   ASIAN JOURNAL OF ANDROLOGY

Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection

(2016) Yoshitaka Shirasago et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

(2016) Takashi Yamano et al.   CELL

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

(2016) R Kaminski et al.   GENE THERAPY

Programmable Site-Specific Nucleases for Targeted Genome Engineering in Higher Eukaryotes

(2016) Ganesan Govindan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of clinical pathogenic herpes simplex virus 1 strains with enzymatically created siRNA pools

(2016) Henrik Paavilainen et al.   JOURNAL OF MEDICAL VIROLOGY

Highly Efficient CRISPR/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains

(2016) Teru Kanda et al.   JOURNAL OF VIROLOGY

Anti-HIV-1 potency of the CRISPR/Cas9 system insufficient to fully inhibit viral replication

(2016) Shuhei Ueda et al.   MICROBIOLOGY AND IMMUNOLOGY

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA

(2016) Christoph Seeger et al.   MOLECULAR THERAPY

Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

(2016) Sheena M Saayman et al.   MOLECULAR THERAPY

CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape

(2016) Gang Wang et al.   MOLECULAR THERAPY

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

(2016) Janet Karpinski et al.   NATURE BIOTECHNOLOGY

CRISPR/Cas9: a double-edged sword when used to combat HIV infection

(2016) Chen Liang et al.   Retrovirology

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense

(2016) Aryn A. Price et al.   TRENDS IN MICROBIOLOGY

SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells

(2016) Serena Bonifati et al.   VIROLOGY

Pseudorabies virus can escape from CRISPR-Cas9-mediated inhibition

(2016) Zhiyuan Peng et al.   VIRUS RESEARCH

CRISPR/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse

(2016) Wei Zhu et al.   VIRUS RESEARCH

The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely

(2016) Xiaoyan Guo et al.   Scientific Reports

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape

(2016) Zhen Wang et al.   Cell Reports

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

(2016) Rafal Kaminski et al.   Scientific Reports

Inhibition of HSV-1 Replication by Gene Editing Strategy

(2016) Pamela C. Roehm et al.   Scientific Reports

Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9

(2016) Kristine E. Yoder et al.   Scientific Reports

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy

(2016) Rafal Kaminski et al.   Scientific Reports

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication

(2015) Chunsheng Dong et al.   ANTIVIRAL RESEARCH

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus

(2015) S Zhen et al.   GENE THERAPY

Selection of a hepatitis C virus with altered entry factor requirements reveals a genetic interaction between the E1 glycoprotein and claudins

(2015) Sharon E. Hopcraft et al.   HEPATOLOGY

Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo

(2015) Hun Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome

(2015) Xing Liu et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9

(2015) Chang Li et al.   JOURNAL OF GENERAL VIROLOGY

Genome editing strategies: potential tools for eradicating HIV-1/AIDS

(2015) Kamel Khalili et al.   JOURNAL OF NEUROVIROLOGY

The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1

(2015) Elizabeth M. Turner et al.   JOURNAL OF VIROLOGY

Cas9-mediated targeting of viral RNA in eukaryotic cells

(2015) Aryn A. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA

(2015) Weijun Zhu et al.   Retrovirology

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

(2015) Edward M. Kennedy et al.   VIROLOGY

Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication

(2015) Jie Wang   WORLD JOURNAL OF GASTROENTEROLOGY

CCR5 Targeted Cell Therapy for HIV and Prevention of Viral Escape

(2015) Gero Hütter et al.   Viruses-Basel

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

(2015) Hsin-Kai Liao et al.   Nature Communications

Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing

(2015) Manuel Kaulich et al.   Nucleic Acid Therapeutics

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

(2015) Vyas Ramanan et al.   Scientific Reports

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X

(2015) Madina Karimova et al.   Scientific Reports

Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection

(2015) Panpan Hou et al.   Scientific Reports

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

(2015) Yonggang Zhang et al.   Scientific Reports

RNA interference approaches for treatment of HIV-1 infection

(2015) Maggie L Bobbin et al.   Genome Medicine

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

(2015) HyunJun Kang et al.   Molecular Therapy-Nucleic Acids

Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical Cancer

(2015) Hun Jung et al.   Journal of Clinical Medicine

Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs

(2015) Ming Yan et al.   PLoS One

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection

(2015) Hassen S. Wollebo et al.   PLoS One

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9

(2014) Shuai Zhen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TALEN-mediated genome editing: prospects and perspectives

(2014) David A. Wright et al.   BIOCHEMICAL JOURNAL

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells

(2014) Matthew C. Canver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells

(2014) K.-S. Yuen et al.   JOURNAL OF GENERAL VIROLOGY

Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease

(2014) E. M. Kennedy et al.   JOURNAL OF VIROLOGY

CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection

(2014) Weiming Wang et al.   PLoS One

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells

(2014) K. Felgentreff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

(2014) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

(2014) Karen E. Johnson et al.   PLoS Pathogens

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

Targeting Hepatitis B Virus With CRISPR/Cas9

(2014) Christoph Seeger et al.   Molecular Therapy-Nucleic Acids

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

(2013) Ilona Hauber et al.   PLoS Pathogens

Engineered DNA modifying enzymes: Components of a future strategy to cure HIV/AIDS

(2012) Frank Buchholz et al.   ANTIVIRAL RESEARCH

In Search of the Most Suitable Lentiviral shRNA System

(2009) Tomas Bos et al.   CURRENT GENE THERAPY

Probing the sequence space available for HIV-1 evolution

(2008) Olivier ter Brake et al.   AIDS