RNA interference approaches for treatment of HIV-1 infection

Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs

(2014) Hal P. Bogerd et al.   JOURNAL OF VIROLOGY

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation

(2014) Lambros Kordelas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

(2014) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of antisense long noncoding RNA in small RNA-triggered gene activation

(2014) Xizhe Zhang et al.   RNA

The Mammalian Response to Virus Infection Is Independent of Small RNA Silencing

(2014) Simone Backes et al.   Cell Reports

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA

(2014) Robert J Scarborough et al.   Molecular Therapy-Nucleic Acids

Preclinical safety and efficacy of an anti–HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor

(2014) Orit Wolstein et al.   Molecular Therapy-Methods & Clinical Development

Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors

(2013) Fatima Boutimah et al.   ANTIVIRAL RESEARCH

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

(2013) C. A. Didigu et al.   BLOOD

Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes

(2013) Wen-Wen Xu et al.   BMC Medical Genomics

Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS

(2013) Janet Chung et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

(2013) Dawn A. Maier et al.   HUMAN GENE THERAPY

Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA

(2013) A. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Advancements in the field of intravaginal siRNA delivery

(2013) Sidi Yang et al.   JOURNAL OF CONTROLLED RELEASE

Liposome Delivery of MicroRNA-145 to Mesenchymal Stem Cells Leads to Immunological Off-target Effects Mediated by RIG-I

(2013) Tommy A Karlsen et al.   MOLECULAR THERAPY

Durable Knockdown and Protection From HIV Transmission in Humanized Mice Treated With Gel-formulated CD4 Aptamer-siRNA Chimeras

(2013) Lee Adam Wheeler et al.   MOLECULAR THERAPY

Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases

(2013) Lijing Li et al.   MOLECULAR THERAPY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway

(2013) Hongyan Sui et al.   NUCLEIC ACIDS RESEARCH

Dicer-independent processing of short hairpin RNAs

(2013) Y. P. Liu et al.   NUCLEIC ACIDS RESEARCH

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

(2013) V. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals

(2013) Y. Li et al.   SCIENCE

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Development of Hematopoietic Stem Cell Based Gene Therapy for HIV-1 Infection: Considerations for Proof of Concept Studies and Translation to Standard Medical Practice

(2013) David DiGiusto et al.   Viruses-Basel

CCR5 as a Natural and Modulated Target for Inhibition of HIV

(2013) Bryan Burke et al.   Viruses-Basel

Targeted gene disruption to cure HIV

(2013) Daniel Stone et al.   Current Opinion in HIV and AIDS

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting

(2013) Nicholas M Snead et al.   Molecular Therapy-Nucleic Acids

Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing

(2013) Kazuo Suzuki et al.   Molecular Therapy-Nucleic Acids

Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1

(2013) Mireille Centlivre et al.   Molecular Therapy-Nucleic Acids

Degradation of Host MicroRNAs by Poxvirus Poly(A) Polymerase Reveals Terminal RNA Methylation as a Protective Antiviral Mechanism

(2012) Simone Backes et al.   Cell Host & Microbe

Creating genetic resistance to HIV

(2012) John C Burnett et al.   CURRENT OPINION IN IMMUNOLOGY

Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles

(2012) Yang Pan et al.   FEBS Journal

Endogenous MCM7 MicroRNA Cluster as a Novel Platform to Multiplex Small Interfering and Nucleolar RNAs for Combinational HIV-1 Gene Therapy

(2012) Janet Chung et al.   HUMAN GENE THERAPY

The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope

(2012) M. S. de Souza et al.   JOURNAL OF IMMUNOLOGY

Single siRNA Nanocapsules for Enhanced RNAi Delivery

(2012) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment

(2012) Jinyun Yuan et al.   MOLECULAR THERAPY

HIV Develops Indirect Cross-resistance to Combinatorial RNAi Targeting Two Distinct and Spatially Distant Sites

(2012) Priya S Shah et al.   MOLECULAR THERAPY

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

(2012) Rosemary L Kanasty et al.   MOLECULAR THERAPY

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

(2012) Jiehua Zhou et al.   MOLECULAR THERAPY

Coupling endonucleases with DNA end–processing enzymes to drive gene disruption

(2012) Michael T Certo et al.   NATURE METHODS

Excision of HIV-1 Proviral DNA by Recombinant Cell Permeable Tre-Recombinase

(2012) Lakshmikanth Mariyanna et al.   PLoS One

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

(2012) Frauke Christ et al.   VIROLOGY

Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors

(2012) Julia JM Eekels et al.   Virology Journal

Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells

(2012) Victoria A Green et al.   Virology Journal

Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

(2012) Tao Zhang et al.   Virology Journal

Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

(2012) Kate E Broderick et al.   Molecular Therapy-Nucleic Acids

Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

(2012) Stuart Knowling et al.   Molecular Therapy-Nucleic Acids

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3′ Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

(2012) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Directed HIV-1 Evolution of Protease Inhibitor Resistance by Second-Generation Short Hairpin RNAs

(2011) Nick C. T. Schopman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular strategies to design an escape-proof antiviral therapy

(2011) Ben Berkhout et al.   ANTIVIRAL RESEARCH

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

The effects of stem length and core placement on shRNA activity

(2011) Glen J Mcintyre et al.   BMC MOLECULAR BIOLOGY

Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic Acids

(2011) Erica B. Schleifman et al.   CHEMISTRY & BIOLOGY

Localized, Targeted, and Sustained siRNA Delivery

(2011) Melissa D. Krebs et al.   CHEMISTRY-A EUROPEAN JOURNAL

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

(2011) Andrew Prussia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cellular TAR RNA Binding Protein, TRBP, Promotes HIV-1 Replication Primarily by Inhibiting the Activation of Double-Stranded RNA-Dependent Kinase PKR

(2011) V. R. Sanghvi et al.   JOURNAL OF VIROLOGY

Gag Induces the Coalescence of Clustered Lipid Rafts and Tetraspanin-Enriched Microdomains at HIV-1 Assembly Sites on the Plasma Membrane

(2011) I. B. Hogue et al.   JOURNAL OF VIROLOGY

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

(2011) Jiehua Zhou et al.   METHODS

Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice

(2011) Jiehua Zhou et al.   MOLECULAR THERAPY

Progress Toward In Vivo Use of siRNAs-II

(2011) Garrett R Rettig et al.   MOLECULAR THERAPY

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

(2011) Martine Aubert et al.   PLoS One

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

(2011) Daniel R. Caffrey et al.   PLoS One

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific

(2011) Kazuo Suzuki et al.   RNA Biology

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Eradication of HIV by Transplantation of CCR5-Deficient Hematopoietic Stem Cells

(2011) Gero Hütter et al.   TheScientificWorldJOURNAL

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

(2011) Craig B. Wilen et al.   PLoS Pathogens

Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART

(2011) Maria J. Buzón et al.   PLoS Pathogens

Multiple shRNA combinations for near-complete coverage of all HIV-1 strains

(2011) Glen J Mcintyre et al.   AIDS Research and Therapy

Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt

(2011) Ronald T. Mitsuyasu et al.   Stem Cells International

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors

(2010) Julia J.M. Eekels et al.   ANTIVIRAL RESEARCH

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?

(2010) Sandesh Subramanya et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV

(2010) Monica Vaccari et al.   Expert Review of Vaccines

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

(2010) Dirk Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro evolution and analysis of HIV-1 LTR-specific recombinases

(2010) Frank Buchholz et al.   METHODS

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Lentiviral Vector Gene Therapy: Effective and Safe?

(2010) Derek A Persons   MOLECULAR THERAPY

Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA

(2010) Sandesh Subramanya et al.   MOLECULAR THERAPY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

(2010) Nick CT Schopman et al.   Retrovirology

Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies

(2010) Y. P. Liu et al.   RNA

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle

(2010) Hoshang J Unwalla et al.   Virology Journal

Viral RNA silencing suppressors (RSS): Novel strategy of viruses to ablate the host RNA interference (RNAi) defense system

(2010) Shalmali Bivalkar-Mehla et al.   VIRUS RESEARCH

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems

(2010) Poornima Parameswaran et al.   PLoS Pathogens

Coreceptors and HIV-1 Pathogenesis

(2010) Paul R. Gorry et al.   Current HIV/AIDS Reports

Progress towards Therapeutic Application of RNA Interference for HIV Infection

(2009) Sunit K. Singh et al.   BIODRUGS

The role of RNAi and microRNAs in animal virus replication and antiviral immunity

(2009) J. L. Umbach et al.   GENES & DEVELOPMENT

Long-term RNA interference and its application to hepatitis B virus

(2009) Jin Shui PAN et al.   Journal of Digestive Diseases

Combinatorial RNAi Against HIV-1 Using Extended Short Hairpin RNAs

(2009) Ying Poi Liu et al.   MOLECULAR THERAPY

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

(2009) Ronald T Mitsuyasu et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome

(2009) Lyubov Zaitseva et al.   Retrovirology

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism

(2008) Joshua N. Leonard et al.   Cell Host & Microbe

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2-/-γc-/-) mouse model

(2008) O ter Brake et al.   GENE THERAPY

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

(2008) Kazuo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of Cellular RNA Helicase DDX3 by Short Hairpin RNAs Suppresses HIV-1 Viral Replication Without Inducing Apoptosis

(2008) Musarat Ishaq et al.   MOLECULAR BIOTECHNOLOGY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

(2008) Masayuki Sano et al.   NUCLEIC ACIDS RESEARCH

Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

(2008) Mayur Tamhane et al.   AIDS Research and Therapy

Chemically modified symmetric and asymmetric duplex RNAs: An enhanced stability to nuclease degradation and gene silencing effect

(2007) Takanori Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS