Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

Risk Factors and Mortality Associated With Resistance to First-Line Antiretroviral Therapy

(2015) Loretxu Pinoges et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors

(2015) Xiaoling Wang et al.   NATURE BIOTECHNOLOGY

Bone Marrow Gene Therapy for HIV/AIDS

(2015) Elena Herrera-Carrillo et al.   Viruses-Basel

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

(2015) Robert C. Münch et al.   Nature Communications

Finding a Cure for Human Immunodeficiency Virus-1 Infection

(2014) Joel N. Blankson et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

An HIV Cure

(2014) Anthony S. Fauci et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection

(2014) Trevor A. Crowell et al.   JOURNAL OF INFECTIOUS DISEASES

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

(2014) Cagla Akay et al.   JOURNAL OF NEUROVIROLOGY

HIV infection: epidemiology, pathogenesis, treatment, and prevention

(2014) Gary Maartens et al.   LANCET

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

A guide to genome engineering with programmable nucleases

(2014) Hyongbum Kim et al.   NATURE REVIEWS GENETICS

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV cure research: Advances and prospects

(2014) Caroline P. Passaes et al.   VIROLOGY

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies

(2014) Angela Battistini et al.   Viruses-Basel

Treatment modification in HIV-Infected individuals starting antiretroviral therapy between 2011 and 2014

(2014) Michaela Rappold et al.   Journal of the International AIDS Society

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

(2013) Christine Katlama et al.   LANCET

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

(2013) Xiying Qu et al.   NUCLEIC ACIDS RESEARCH

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4+ T-cells Contain One HIV-1 DNA Molecule

(2013) Lina Josefsson et al.   PLoS Pathogens

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

(2013) Ilona Hauber et al.   PLoS Pathogens

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach

(2012) Josephine Abi-Ghanem et al.   NUCLEIC ACIDS RESEARCH

Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system

(2012) Madina Karimova et al.   NUCLEIC ACIDS RESEARCH

Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study

(2012) Kathy Petoumenos et al.   Journal of the International AIDS Society

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(2011) L. J. Scherer et al.   HUMAN MOLECULAR GENETICS

An unbiased genome-wide analysis of zinc-finger nuclease specificity

(2011) Richard Gabriel et al.   NATURE BIOTECHNOLOGY

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

(2011) Vikram Pattanayak et al.   NATURE METHODS

VCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering

(2011) Emiko Suzuki et al.   NUCLEIC ACIDS RESEARCH

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

(2011) L. Josefsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Inactivating Alpharetroviral Vectors with a Split-Packaging Design

(2010) J. D. Suerth et al.   JOURNAL OF VIROLOGY

In vitro evolution and analysis of HIV-1 LTR-specific recombinases

(2010) Frank Buchholz et al.   METHODS

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

SeLOX—a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems

(2010) Vineeth Surendranath et al.   NUCLEIC ACIDS RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

PatMaN: rapid alignment of short sequences to large databases

(2008) Kay Prüfer et al.   BIOINFORMATICS

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

The Challenge of HIV-1 Subtype Diversity

(2008) Barbara S. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE