Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology

(2016) Paul S. Callaghan et al.   MALARIA JOURNAL

A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax

(2016) C. Brandon Ogbunugafor et al.   MALARIA JOURNAL

Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum

(2016) Stanislaw J. Gabryszewski et al.   MOLECULAR BIOLOGY AND EVOLUTION

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance

(2016) C. Brandon Ogbunugafor et al.   PLoS Computational Biology

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter

(2016) Sashika N. Richards et al.   PLoS Pathogens

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

(2015) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

(2015) Paul S. Callaghan et al.   BIOCHEMISTRY

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

(2015) Sophie H. Adjalley et al.   BMC GENOMICS

Understanding artemisinin-resistant malaria

(2015) Rick M. Fairhurst   CURRENT OPINION IN INFECTIOUS DISEASES

Quinine conjugates and quinine analogues as potential antimalarial agents

(2015) Rachel A. Jones et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial

(2015) Adoke Yeka et al.   JOURNAL OF INFECTIOUS DISEASES

High-Dose Chloroquine for Treatment of Chloroquine-ResistantPlasmodium falciparumMalaria

(2015) Johan Ursing et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

(2015) Jill M. Combrinck et al.   MALARIA JOURNAL

Balancing drug resistance and growth rates via compensatory mutations in thePlasmodium falciparumchloroquine resistance transporter

(2015) Ines Petersen et al.   MOLECULAR MICROBIOLOGY

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

(2015) Diarmaid Hughes et al.   NATURE REVIEWS GENETICS

Plasmodium falciparumchloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter

(2015) Narinobu Juge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt

(2015) Stéphane Pelleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

(2015) Serena Pulcini et al.   Scientific Reports

The Peculiarities and Paradoxes of Plasmodium Heme Metabolism

(2014) Paul A. Sigala et al.   Annual Review of Microbiology

What can we learn from fitness landscapes?

(2014) Daniel L Hartl   CURRENT OPINION IN MICROBIOLOGY

Return of Widespread Chloroquine-Sensitive Plasmodium falciparum to Malawi

(2014) Anne E. P. Frosch et al.   JOURNAL OF INFECTIOUS DISEASES

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

(2014) R. L. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pfcrt mutant haplotypes may not correspond with chloroquine resistance

(2014) Diganta Goswami et al.   Journal of Infection in Developing Countries

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

(2014) Marcus CS Lee et al.   Genome Medicine

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

(2014) Ian A. Lewis et al.   PLoS Genetics

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

(2014) Rebecca D. Sandlin et al.   International Journal for Parasitology-Drugs and Drug Resistance

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

(2013) Christine A. Hrycyna et al.   ACS Chemical Biology

Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

(2013) Nicholas K. Baro et al.   BIOCHEMISTRY

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

(2013) Alexander P. Gorka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malaria

(2013) Nicholas J White et al.   LANCET

Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia

(2013) Sungano Mharakurwa et al.   MALARIA JOURNAL

The interplay between drug resistance and fitness in malaria parasites

(2013) Philip J. Rosenthal   MOLECULAR MICROBIOLOGY

Complex nature of malaria parasite hemoglobin degradation

(2013) D. E. Goldberg   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Glutathione Transport: A New Role for PfCRT in Chloroquine Resistance

(2012) Eva-Maria Patzewitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

(2012) Judith Straimer et al.   NATURE METHODS

Harnessing genomics and genome biology to understand malaria biology

(2012) Sarah K. Volkman et al.   NATURE REVIEWS GENETICS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

(2012) Janni Papakrivos et al.   PLoS One

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analysis of Chloroquine Resistance Transporter (CRT) Isoforms and Orthologues inS. cerevisiaeYeast

(2011) Nicholas K. Baro et al.   BIOCHEMISTRY

Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

(2011) Adele M. Lehane et al.   International Journal for Parasitology-Drugs and Drug Resistance

Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

(2010) K. Beshir et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PfCRT-Mediated Drug Transport in Malarial Parasites

(2010) Paul D. Roepe   BIOCHEMISTRY

Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

(2010) S. C. Maughan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

Chloroquine Transport inPlasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe

(2009) Mynthia Cabrera et al.   BIOCHEMISTRY

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Effects of Quinoline Antimalarials on Endocytosis in Plasmodium falciparum

(2008) L. Roberts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

(2008) Hongying Jiang et al.   PLoS One

Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum

(2008) D. A. Elliott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA