The Peculiarities and Paradoxes of Plasmodium Heme Metabolism

Heme-binding properties of heme detoxification protein from Plasmodium falciparum

(2013) Keisuke Nakatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

(2013) James I MacRae et al.   BMC BIOLOGY

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Synergy of ferrous ion on 5-aminolevulinic acid-mediated growth inhibition of Plasmodium falciparum

(2013) Keisuke Komatsuya et al.   JOURNAL OF BIOCHEMISTRY

Plasmodium falciparumMerozoite Surface Protein 3

(2013) Maryam Imam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways inPlasmodium falciparum

(2013) Simon A. Cobbold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis

(2013) A. Butykai et al.   Scientific Reports

The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

(2013) Jolyn E. Gisselberg et al.   PLoS Pathogens

Make It, Take It, or Leave It: Heme Metabolism of Parasites

(2013) Luděk Kořený et al.   PLoS Pathogens

Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection

(2013) Viswanathan Arun Nagaraj et al.   PLoS Pathogens

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Quantitative Imaging with Fluorescent Biosensors

(2012) Sakiko Okumoto et al.   Annual Review of Plant Biology

Relative to Quinine and Quinidine, Their 9-Epimers Exhibit Decreased Cytostatic Activity and Altered Heme Binding but Similar Cytocidal Activity versus Plasmodium falciparum

(2012) Alexander P. Gorka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth

(2012) Alexander P. Gorka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Use and Abuse of Heme in Apicomplexan Parasites

(2012) Giel G. van Dooren et al.   ANTIOXIDANTS & REDOX SIGNALING

One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

(2012) Iqbal Hamza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of Malaria Pigment and Related Propanoate-Linked Metalloporphyrin Dimers

(2012) D. Scott Bohle et al.   CHEMISTRY & BIODIVERSITY

Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

(2012) A. Hino et al.   JOURNAL OF BIOCHEMISTRY

Direct Tests of Enzymatic Heme Degradation by the Malaria ParasitePlasmodium falciparum

(2012) Paul A. Sigala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging mass spectrometry of thin tissue sections: A decade of collective efforts

(2012) Pierre Chaurand   Journal of Proteomics

Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition

(2012) Melvin A Ambele et al.   MALARIA JOURNAL

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

(2012) S. Takala-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum

(2012) S. Kapishnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability

(2012) L. Koreny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

(2011) Faustine Dubar et al.   CHEMICAL COMMUNICATIONS

Variation among Plasmodium falciparum Strains in Their Reliance on Mitochondrial Electron Transport Chain Function

(2011) Hangjun Ke et al.   EUKARYOTIC CELL

The Threat of Artemisinin-Resistant Malaria

(2011) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

(2011) Luděk Kořený et al.   PLANT CELL

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructural and Real-time Microscopic Changes inP. falciparum-infected Red Blood Cells Following Treatment with Antimalarial Drugs

(2011) Navakanit Sachanonta et al.   ULTRASTRUCTURAL PATHOLOGY

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

In vivouptake of a haem analogue Zn protoporphyrin IX by the human malaria parasiteP. falciparum-infected red blood cells

(2010) Robson Sartorello et al.   CELL BIOLOGY INTERNATIONAL

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

(2010) Jonathan P. Celli et al.   CHEMICAL REVIEWS

Inhibiting Plasmodium cytochrome bc1: a complex issue

(2010) Victoria Barton et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Iron and Porphyrin Trafficking in Heme Biogenesis

(2010) Iman J. Schultz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

(2010) N. A. Bakar et al.   JOURNAL OF CELL SCIENCE

Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion

(2010) Viswanathan Arun Nagaraj et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Heme and blood-feeding parasites: friends or foes?

(2010) Shu Toh et al.   Parasites & Vectors

The evolution, metabolism and functions of the apicoplast

(2010) L. Lim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

The cell biology of tetrapyrroles: a life and death struggle

(2010) Nobuyoshi Mochizuki et al.   TRENDS IN PLANT SCIENCE

Trafficking of Heme and Porphyrins in Metazoa

(2009) Scott Severance et al.   CHEMICAL REVIEWS

Autofluorescence of Condensed Heme Aggregates in Malaria Pigment and Its Synthetic Equivalent Hematin Anhydride (β-Hematin)

(2009) Marie-Josée Bellemare et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mitochondrial localization of functional ferrochelatase from Plasmodium falciparum

(2009) Viswanathan Arun Nagaraj et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Characterization of coproporphyrinogen III oxidase in Plasmodium falciparum cytosol

(2009) Viswanathan Arun Nagaraj et al.   PARASITOLOGY INTERNATIONAL

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Spatial distribution of heme species in erythrocytes infected with Plasmodium falciparum by use of resonance Raman imaging and multivariate analysis

(2008) Alois Bonifacio et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

The novel heme oxygenase-like protein fromPlasmodiumfalciparumconverts heme to bilirubin IXα in the apicoplast

(2008) Ken Okada   FEBS LETTERS

Localisation of Plasmodium falciparum uroporphyrinogen III decarboxylase of the heme-biosynthetic pathway in the apicoplast and characterisation of its catalytic properties

(2008) Viswanathan Arun Nagaraj et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Extensive Analysis of the Cytoplasmic Proteome of Human Erythrocytes Using the Peptide Ligand Library Technology and Advanced Mass Spectrometry

(2008) Florence Roux-Dalvai et al.   MOLECULAR & CELLULAR PROTEOMICS

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

HDP—A Novel Heme Detoxification Protein from the Malaria Parasite

(2008) Dewal Jani et al.   PLoS Pathogens