Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

(2016) Richard T. Eastman et al.   Scientific Reports

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

(2015) Paul S. Callaghan et al.   BIOCHEMISTRY

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

(2015) Sophie H. Adjalley et al.   BMC GENOMICS

Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite

(2015) Geoffrey H Siwo et al.   BMC GENOMICS

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via thePlasmodium falciparumChloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs

(2015) Donelly A. van Schalkwyk et al.   JOURNAL OF INFECTIOUS DISEASES

Balancing drug resistance and growth rates via compensatory mutations in thePlasmodium falciparumchloroquine resistance transporter

(2015) Ines Petersen et al.   MOLECULAR MICROBIOLOGY

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt

(2015) Stéphane Pelleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collateral sensitivity of antibiotic-resistant microbes

(2015) Csaba Pál et al.   TRENDS IN MICROBIOLOGY

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

(2015) Serena Pulcini et al.   Scientific Reports

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

(2014) Meera Venkatesan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Identification and Deconvolution of Cross-Resistance Signals from Antimalarial Compounds Using Multidrug-Resistant Plasmodium falciparum Strains

(2014) Monika Chugh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiple Drugs Compete for Transport via thePlasmodium falciparumChloroquine Resistance Transporter at Distinct but Interdependent Sites

(2014) Sebastiano Bellanca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Impacts Over 5 Years of Artemisinin-Based Combination Therapies on Plasmodium falciparum Polymorphisms That Modulate Drug Sensitivity in Ugandan Children

(2014) Melissa D. Conrad et al.   JOURNAL OF INFECTIOUS DISEASES

In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine

(2014) Rajnish Sahu et al.   MALARIA JOURNAL

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

(2014) A. K. Lukens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

(2014) R. L. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

(2014) Karen J. Deane et al.   ACS Medicinal Chemistry Letters

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

(2014) Ian A. Lewis et al.   PLoS Genetics

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

(2013) Christine A. Hrycyna et al.   ACS Chemical Biology

Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

(2013) Nicholas K. Baro et al.   BIOCHEMISTRY

Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

(2013) Christina Spry et al.   PLoS One

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Saquinavir Inhibits the Malaria Parasite's Chloroquine Resistance Transporter

(2012) Rowena E. Martin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutation in the Plasmodium falciparum CRT Protein Determines the Stereospecific Activity of Antimalarial Cinchona Alkaloids

(2012) Carol E. Griffin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

(2012) Robert L. Summers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Collateral sensitivity as a strategy against cancer multidrug resistance

(2012) Kristen M. Pluchino et al.   DRUG RESISTANCE UPDATES

Tricks in Plasmodium’s molecular repertoire – Escaping 3′UTR excision-based conditional silencing of the chloroquine resistance transporter gene

(2012) Andrea Ecker et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

(2012) Janni Papakrivos et al.   PLoS One

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

(2012) Michael Delves et al.   PLOS MEDICINE

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

(2011) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum

(2011) Daria Van Tyne et al.   PLoS Genetics

Selection of Known Plasmodium falciparum Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso

(2010) A. F. Some et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

(2010) Jana Held et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": Implications for chemotherapy

(2010) Robert L. Summers et al.   Virulence

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1

(2009) L. Mwai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparum culture: The benefits of shaking

(2009) Richard J.W. Allen et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole

(2008) A. M. Lehane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

(2008) A. M. Lehane et al.   JOURNAL OF CELL SCIENCE

Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

(2008) Hongying Jiang et al.   PLoS One

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

(2008) X. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA