Balancing drug resistance and growth rates via compensatory mutations in thePlasmodium falciparumchloroquine resistance transporter

Multiple Drugs Compete for Transport via thePlasmodium falciparumChloroquine Resistance Transporter at Distinct but Interdependent Sites

(2014) Sebastiano Bellanca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

(2014) R. L. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum

(2014) Cecilia P. Sanchez et al.   PLoS Genetics

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

(2014) Ian A. Lewis et al.   PLoS Genetics

Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum

(2013) Christine A. Hrycyna et al.   ACS Chemical Biology

Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

(2013) Nicholas K. Baro et al.   BIOCHEMISTRY

Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia

(2013) Sungano Mharakurwa et al.   MALARIA JOURNAL

In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene

(2013) Aurélie Pascual et al.   MALARIA JOURNAL

The interplay between drug resistance and fitness in malaria parasites

(2013) Philip J. Rosenthal   MOLECULAR MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

A Process Similar to Autophagy Is Associated with Cytocidal Chloroquine Resistance in Plasmodium falciparum

(2013) David Gaviria et al.   PLoS One

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

(2012) Judith Straimer et al.   NATURE METHODS

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

(2011) Juliana M Sa et al.   MALARIA JOURNAL

Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data

(2011) Anne EP Frosch et al.   MALARIA JOURNAL

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

(2011) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

The Threat of Artemisinin-Resistant Malaria

(2011) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

(2010) K. Beshir et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela

(2010) S. Griffing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Return of Chloroquine‐Susceptible Falciparum Malaria in Malawi Was a Reexpansion of Diverse Susceptible Parasites

(2010) Miriam K. Laufer et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence That Mutant PfCRT Facilitates the Transmission to Mosquitoes of Chloroquine-Treated Plasmodium Gametocytes

(2010) Andrea Ecker et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene

(2010) Bianca E Gama et al.   MALARIA JOURNAL

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

(2010) Jigar J. Patel et al.   MOLECULAR MICROBIOLOGY

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India

(2009) T. Mixson-Hayden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduced Digestive Vacuolar Accumulation of Chloroquine Is Not Linked to Resistance to Chloroquine Toxicity

(2009) Mynthia Cabrera et al.   BIOCHEMISTRY

Longitudinal Survey ofPlasmodium falciparumInfection in Vietnam: Characteristics of Antimalarial Resistance and Their Associated Factors

(2009) Rie Isozumi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Chloroquine resistance before and after its withdrawal in Kenya

(2009) Leah Mwai et al.   MALARIA JOURNAL

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes

(2008) Eric H. Ekland et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy

(2008) Bojana Gligorijevic et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE