Journal
BIOCHEMISTRY
Volume 50, Issue 2, Pages 163-171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi101638n
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Funding
- Burroughs Wellcome Foundation
- Luce Foundation
- U.S. Department of Defense
- National Institutes of Health [RO1 AI045957, AI056312, AI052312, AI060792, AI071121]
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A wide range of drug transport studies using intact infected red blood cells, isolated malarial parasites, heterologous expression systems, and purified protein, combined with elegant genetic experiments, have suggested that chloroquine transport by the Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key aspect of the molecular mechanism of quinoline antimalarial drug resistance. However, many questions remain. This short review summarizes data that have led to drug channel versus drug pump hypotheses for PfCRT and suggests ways in which recent contrasting interpretations might be reconciled.
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