Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Therapeutic Efficacy of Chloroquine for the Treatment of Uncomplicated Plasmodium falciparum in Haiti After Many Decades of Its Use

(2015) Bernard A. Okech et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase

(2015) Eugene Y. Wu et al.   BIOCHEMISTRY

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

(2015) Paul S. Callaghan et al.   BIOCHEMISTRY

Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

(2015) Valentine Duru et al.   BMC Medicine

Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype

(2015) Tyler S. Brown et al.   INFECTION GENETICS AND EVOLUTION

Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

(2015) Tamarah Koleala et al.   MALARIA JOURNAL

Balancing drug resistance and growth rates via compensatory mutations in thePlasmodium falciparumchloroquine resistance transporter

(2015) Ines Petersen et al.   MOLECULAR MICROBIOLOGY

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

(2015) Diarmaid Hughes et al.   NATURE REVIEWS GENETICS

Advances in molecular genetic systems in malaria

(2015) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt

(2015) Stéphane Pelleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

(2015) Adam C. Palmer et al.   Nature Communications

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

(2014) Meera Venkatesan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia

(2014) Chanaki Amaratunga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

What can we learn from fitness landscapes?

(2014) Daniel L Hartl   CURRENT OPINION IN MICROBIOLOGY

DNA sequence polymorphisms of the pfmdr1 gene and association of mutations with the pfcrt gene in Indian Plasmodium falciparum isolates

(2014) Kshipra Chauhan et al.   INFECTION GENETICS AND EVOLUTION

Differential Prevalence of Transporter Polymorphisms in Symptomatic and Asymptomatic Falciparum Malaria Infections in Uganda

(2014) S. Tukwasibwe et al.   JOURNAL OF INFECTIOUS DISEASES

Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

(2014) Gisela Henriques et al.   JOURNAL OF INFECTIOUS DISEASES

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia

(2014) Seleshi Mekonnen et al.   MALARIA JOURNAL

Origin of Robustness in Generating Drug-Resistant Malaria Parasites

(2014) Krittikorn Kümpornsin et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

(2014) R. L. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Full-Length Sequence Analysis of Chloroquine Resistance Transporter Gene inPlasmodium falciparumIsolates from Sabah, Malaysia

(2014) Lii Lian Tan et al.   TheScientificWorldJOURNAL

Pfcrt mutant haplotypes may not correspond with chloroquine resistance

(2014) Diganta Goswami et al.   Journal of Infection in Developing Countries

Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis

(2014) Antoine Claessens et al.   PLoS Genetics

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

(2014) Ian A. Lewis et al.   PLoS Genetics

Molecular Surveillance as Monitoring Tool for Drug-Resistant Plasmodium falciparum in Suriname

(2013) Malti R. Adhin et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Function of Resistance Conferring Plasmodium falciparum Chloroquine Resistance Transporter Isoforms

(2013) Nicholas K. Baro et al.   BIOCHEMISTRY

Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter

(2013) Timothy J Egan et al.   Future Microbiology

Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax

(2013) Pan-Pan Jiang et al.   JOURNAL OF MOLECULAR EVOLUTION

Malaria

(2013) Nicholas J White et al.   LANCET

Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia

(2013) Sungano Mharakurwa et al.   MALARIA JOURNAL

A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

(2013) Aamer A Khattak et al.   MALARIA JOURNAL

The interplay between drug resistance and fitness in malaria parasites

(2013) Philip J. Rosenthal   MOLECULAR MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

(2013) Selina E. R. Bopp et al.   PLoS Genetics

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

(2012) Robert L. Summers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure

(2012) Prashant K Mallick et al.   MALARIA JOURNAL

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

(2012) Judith Straimer et al.   NATURE METHODS

Adaptive evolution: evaluating empirical support for theoretical predictions

(2012) Carrie F. Olson-Manning et al.   NATURE REVIEWS GENETICS

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PfCRT and its role in antimalarial drug resistance

(2012) Andrea Ecker et al.   TRENDS IN PARASITOLOGY

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

(2011) Richard T. Eastman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

(2011) Eric H. Ekland et al.   FASEB JOURNAL

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

(2011) Juliana M Sa et al.   MALARIA JOURNAL

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

(2011) Marna S. Costanzo et al.   PLoS One

Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

(2010) K. Beshir et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela

(2010) S. Griffing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PfCRT-Mediated Drug Transport in Malarial Parasites

(2010) Paul D. Roepe   BIOCHEMISTRY

Transporters as mediators of drug resistance in Plasmodium falciparum

(2010) Cecilia P. Sanchez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Return of Chloroquine‐Susceptible Falciparum Malaria in Malawi Was a Reexpansion of Diverse Susceptible Parasites

(2010) Miriam K. Laufer et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence That Mutant PfCRT Facilitates the Transmission to Mosquitoes of Chloroquine-Treated Plasmodium Gametocytes

(2010) Andrea Ecker et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene

(2010) Bianca E Gama et al.   MALARIA JOURNAL

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

(2010) Jigar J. Patel et al.   MOLECULAR MICROBIOLOGY

The Selection Landscape of Malaria Parasites

(2010) M. J. Mackinnon et al.   SCIENCE

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

Revealing evolutionary pathways by fitness landscape reconstruction

(2009) Manjunatha Kogenaru et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Molecular and physiologic basis of quinoline drug resistance inPlasmodium falciparummalaria

(2009) Paul D Roepe   Future Microbiology

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor

(2009) Afonso de Almeida et al.   MALARIA JOURNAL

Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area

(2009) Bianca Gama et al.   MALARIA JOURNAL

Chloroquine resistance before and after its withdrawal in Kenya

(2009) Leah Mwai et al.   MALARIA JOURNAL

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

(2009) Richard T. Eastman et al.   NATURE REVIEWS MICROBIOLOGY

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum

(2008) R. K. Mehlotra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE