shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer’s Disease

(2014) Princi Jain et al.   CURRENT DRUG TARGETS

The small GTPase Rab11 co-localizes with  -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

(2014) O. Chutna et al.   HUMAN MOLECULAR GENETICS

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of  -synuclein, and enhances its secretion and nuclear localization in cells

(2014) M.-B. Fares et al.   HUMAN MOLECULAR GENETICS

Rab-mediated trafficking role in neurite formation

(2014) David Villarroel-Campos et al.   JOURNAL OF NEUROCHEMISTRY

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

(2014) Guowei Yin et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking

(2013) Ye-Jin Chai et al.   FEBS LETTERS

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology

(2013) Sibylle E. Eisbach et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Rab and Arf Proteins in Genetic Diseases

(2013) Elsa Seixas et al.   TRAFFIC

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

(2013) Mitsunori Fukuda   TRAFFIC

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology

(2012) Tatiana I. Slepak et al.   Cytoskeleton

Golgi fragmentation is Rab and SNARE dependent in cellular models of Parkinson’s disease

(2012) Wilson O. Rendón et al.   HISTOCHEMISTRY AND CELL BIOLOGY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CC2D1A Is a Regulator of ESCRT-III CHMP4B

(2012) Nicolas Martinelli et al.   JOURNAL OF MOLECULAR BIOLOGY

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Bacteria and Protozoa Differentially Modulate the Expression of Rab Proteins

(2012) Elsa Seixas et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

(2012) C. Pacheco et al.   Frontiers in Physiology

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the Small GTPase Gene RAB39B Are Responsible for X-linked Mental Retardation Associated with Autism, Epilepsy, and Macrocephaly

(2010) Maila Giannandrea et al.   AMERICAN JOURNAL OF HUMAN GENETICS

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Rab11a and HSP90 Regulate Recycling of Extracellular  -Synuclein

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Control of Cortical Axon Elongation by a GABA-Driven Ca2+/Calmodulin-Dependent Protein Kinase Cascade

(2009) N. Ageta-Ishihara et al.   JOURNAL OF NEUROSCIENCE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

(2009) Xueyi Li et al.   NEUROBIOLOGY OF DISEASE

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

(2009) Chee Yeun Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells

(2008) Rita L. Nokes et al.   JOURNAL OF CELL BIOLOGY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC