Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors

The hypoxic microenvironment: A determinant of cancer stem cell evolution

(2016) Amancio Carnero et al.   BIOESSAYS

Positive feedback loop between cancer stem cells and angiogenesis in hepatocellular carcinoma

(2016) Hong Yao et al.   CANCER LETTERS

Liquid-based three-dimensional tumor models for cancer research and drug discovery

(2016) Stephanie L Ham et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hypoxia regulates stemness of breast cancer MDA-MB-231 cells

(2016) Jing Xie et al.   MEDICAL ONCOLOGY

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapy

(2016) Dong Geon Kim et al.   Oncotarget

Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia

(2016) Andrew Dhawan et al.   Scientific Reports

Interfacial Tension Effect on Cell Partition in Aqueous Two-Phase Systems

(2015) Ehsan Atefi et al.   ACS Applied Materials & Interfaces

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

(2015) Fanying Meng et al.   BMC CANCER

Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer

(2015) Jessica D Sun et al.   CANCER BIOLOGY & THERAPY

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging

(2015) S. G. J. A. Peeters et al.   CLINICAL CANCER RESEARCH

Phytochemicals potently inhibit migration of metastatic breast cancer cells

(2015) Stephanie Lemmo Ham et al.   Integrative Biology

The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast

(2015) Nilgün Kapucuoğlu et al.   PATHOLOGY RESEARCH AND PRACTICE

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models

(2015) Rachit Agarwal et al.   Advanced Healthcare Materials

Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications

(2015) Geon Hui Lee et al.   Advanced Healthcare Materials

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline

(2014) Naoki Aomatsu et al.   BMC CANCER

HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma

(2014) Y J Liu et al.   BRITISH JOURNAL OF CANCER

Enriched CD44+/CD24− population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC)

(2014) Fei Ma et al.   CANCER LETTERS

Optimization of Aqueous Biphasic Tumor Spheroid Microtechnology for Anti-cancer Drug Testing in 3D Culture

(2014) Stephanie Lemmo et al.   Cellular and Molecular Bioengineering

Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic events

(2014) Carolin Bock et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma

(2014) Sant P. Chawla et al.   JOURNAL OF CLINICAL ONCOLOGY

Ultralow Interfacial Tensions of Aqueous Two-Phase Systems Measured Using Drop Shape

(2014) Ehsan Atefi et al.   LANGMUIR

Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer

(2014) Danfang Zhang et al.   Molecular Cancer

Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer

(2014) F. W. Hunter et al.   MOLECULAR CANCER THERAPEUTICS

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia promotes stem cell-like phenotype in multiple myeloma cells

(2014) B Muz et al.   Blood Cancer Journal

Aqueous biphasic cancer cell migration assay enables robust, high-throughput screening of anti-cancer compounds

(2013) Stephanie Lemmo et al.   Biotechnology Journal

Extracellular matrix components in breast cancer progression and metastasis

(2013) Thordur Oskarsson   BREAST

Relapsed Triple-Negative Breast Cancer: Challenges and Treatment Strategies

(2013) Valentina Guarneri et al.   DRUGS

Sox2 promotes tamoxifen resistance in breast cancer cells

(2013) Marco Piva et al.   EMBO Molecular Medicine

Cell to extracellular matrix interactions and their reciprocal nature in cancer

(2013) Marianne van Dijk et al.   EXPERIMENTAL CELL RESEARCH

CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer

(2013) Suresh Kumar Swaminathan et al.   JOURNAL OF CONTROLLED RELEASE

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

CD24 Is an Effector of HIF-1-Driven Primary Tumor Growth and Metastasis

(2012) S. Thomas et al.   CANCER RESEARCH

New strategies for targeting the hypoxic tumour microenvironment in breast cancer

(2012) Carol Ward et al.   CANCER TREATMENT REVIEWS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

(2012) A. Kathleen McClendon et al.   CELL CYCLE

CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma

(2012) Yan Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer stem cells and drug resistance: the potential of nanomedicine

(2012) Serguei Vinogradov et al.   Nanomedicine

Three-Dimensional-Engineered Matrix to Study Cancer Stem Cells and Tumorsphere Formation: Effect of Matrix Modulus

(2012) Xiaoming Yang et al.   TISSUE ENGINEERING PART A

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Radiological features of triple-negative breast cancers (73 cases)

(2012) M. Boisserie-Lacroix et al.   Diagnostic and Interventional Imaging

A CD44−/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer

(2011) Mohamed A. H. Ahmed et al.   BREAST CANCER RESEARCH AND TREATMENT

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

(2011) F. Meng et al.   MOLECULAR CANCER THERAPEUTICS

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1α in ductal carcinoma in situ and invasive ductal carcinoma of breast: An immunohistochemistry-based pilot study

(2011) Zhen Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

Differential Impact of EGFR-Targeted Therapies on Hypoxia Responses: Implications for Treatment Sensitivity in Triple-Negative Metastatic Breast Cancer

(2011) Abderrahim El Guerrab et al.   PLoS One

Polymeric Aqueous Biphasic Systems for Non-Contact Cell Printing on Cells: Engineering Heterocellular Embryonic Stem Cell Niches

(2010) Hossein Tavana et al.   ADVANCED MATERIALS

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel

(2010) Christina H. Stuelten et al.   STEM CELLS

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy

(2009) E Y Tan et al.   BRITISH JOURNAL OF CANCER

Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells

(2009) H. Tavana et al.   NATURE MATERIALS

The clinicopathologic and prognostic significance of CD44+/CD24−/low and CD44−/CD24+ tumor cells in invasive breast carcinomas

(2008) Eleni Mylona et al.   HUMAN PATHOLOGY

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS