Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models

Accelerating the Translation of Nanomaterials in Biomedicine

(2015) Samir Mitragotri et al.   ACS Nano

Probing the relevance of 3D cancer models in nanomedicine research

(2014) David T. Leong et al.   ADVANCED DRUG DELIVERY REVIEWS

Predicting diffusive transport of cationic liposomes in 3-dimensional tumor spheroids

(2014) Michael G. Wientjes et al.   JOURNAL OF CONTROLLED RELEASE

A multilayered cell culture model for transport study in solid tumors: Evaluation of tissue penetration of polyethyleneimine based cationic micelles

(2014) Seiji Miura et al.   Nano Today

Interactions of Skin with Gold Nanoparticles of Different Surface Charge, Shape, and Functionality

(2014) Rute Fernandes et al.   Small

Facing the Truth about Nanotechnology in Drug Delivery

(2013) Kinam Park   ACS Nano

Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug

(2013) Crystal S. Shin et al.   MOLECULAR PHARMACEUTICS

Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications

(2013) Bunyamin Karagoz et al.   Polymer Chemistry

Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms

(2013) R. Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Particle shape enhances specificity of antibody-displaying nanoparticles

(2013) Sutapa Barua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

(2013) P. Kolhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

The Challenge To Relate the Physicochemical Properties of Colloidal Nanoparticles to Their Cytotoxicity

(2012) Pilar Rivera-Gil et al.   ACCOUNTS OF CHEMICAL RESEARCH

Scalable Imprinting of Shape-Specific Polymeric Nanocarriers Using a Release Layer of Switchable Water Solubility

(2012) Rachit Agarwal et al.   ACS Nano

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Plasmid-Templated Shape Control of Condensed DNA-Block Copolymer Nanoparticles

(2012) Xuan Jiang et al.   ADVANCED MATERIALS

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Anti-mitochondrial therapy in human breast cancer multi-cellular spheroids

(2012) Edna Ayerim Mandujano-Tinoco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

(2012) S. Huo et al.   CANCER RESEARCH

The effect of particle size on the biodistribution of low-modulus hydrogel PRINT particles

(2012) Timothy J. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Effect of Aspect Ratio and Deformability on Nanoparticle Extravasation through Nanopores

(2012) Farrell R. Kersey et al.   LANGMUIR

Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation

(2012) Bryan Ronain Smith et al.   NANO LETTERS

Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

(2011) Vikash P. Chauhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacological basis of pegylated liposomal doxorubicin: Impact on cancer therapy

(2011) Alberto Gabizon et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Modeling Particle Shape-Dependent Dynamics in Nanomedicine

(2011) Samar Shah et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

(2011) Eun Chul Cho et al.   Nature Nanotechnology

Intratumoral Drug Delivery with Nanoparticulate Carriers

(2011) Hillary Holback et al.   PHARMACEUTICAL RESEARCH

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

(2011) T. J. Merkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Swelling behavior of nanoscale, shape- and size-specific, hydrogel particles fabricated using imprint lithography

(2011) Mary Caldorera-Moore et al.   Soft Matter

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

(2010) Chunbai He et al.   BIOMATERIALS

Intra-organ biodistribution of gold nanoparticles using intrinsic two-photon-induced photoluminescence

(2010) Jaesook Park et al.   LASERS IN SURGERY AND MEDICINE

Non-specific cellular uptake of surface-functionalized quantum dots

(2010) T A Kelf et al.   NANOTECHNOLOGY

Tuning payload delivery in tumour cylindroids using gold nanoparticles

(2010) Byoungjin Kim et al.   Nature Nanotechnology

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function

(2009) Xinglu Huang et al.   BIOMATERIALS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Red blood cell-mimicking synthetic biomaterial particles

(2009) N. Doshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fabrication of Polymeric Nanorods Using Bilayer Nanoimprint Lithography

(2009) Fatih Buyukserin et al.   Small

Hydrogel nanoparticles in drug delivery

(2008) Mehrdad Hamidi et al.   ADVANCED DRUG DELIVERY REVIEWS

Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen

(2008) I. Safeukui et al.   BLOOD

Advances in PEGylation of important biotech molecules: delivery aspects

(2008) Sinéad M Ryan et al.   Expert Opinion on Drug Delivery

Energy metabolism transition in multi-cellular human tumor spheroids

(2008) Sara Rodríguez-Enríquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications

(2008) Ennio Tasciotti et al.   Nature Nanotechnology

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

(2008) Paolo Decuzzi et al.   PHARMACEUTICAL RESEARCH

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA