Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 134, Issue 3, Pages 801-808Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.395
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Funding
- Cambridge NIHR BRC
- Papworth Hospital NHS trust
- Wellcome Trust [WT092738MA]
- National Institutes of Health [5R01AI093451]
- Asthma UK [05/066] Funding Source: researchfish
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Wound closure requires a complex series of micro-environmentally influenced events. A key aspect of wound closure is the migration of keratinocytes across the open wound. It has been found previously that the response to hypoxia via the HIF-1 alpha transcription factor is a key feature of wound closure. The need for hypoxic response is likely due to interrupted wound vasculature, as well as infection, and in this work we investigated the need for a highly related hypoxic response transcription factor, HIF-2 alpha. This factor was deleted tissue specifically in mice, and the resulting mice were found to have an accelerated rate of wound closure. This is correlated with a reduced bacterial load and inflammatory response in these mice. This indicates that manipulating or reducing the HIF-2 alpha response in keratinocytes could be a useful means to accelerate wound healing and tissue repair.
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