Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

(2014) Marc Bonder et al.   BMC GENOMICS

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children

(2014) Raja Venkatasubramanian et al.   PHARMACOGENOMICS

Association of ABCC2 −24C>T Polymorphism with High-Dose Methotrexate Plasma Concentrations and Toxicities in Childhood Acute Lymphoblastic Leukemia

(2014) Yan Liu et al.   PLoS One

Ethics of Drug Research in the Pediatric Intensive Care Unit

(2014) Niina Kleiber et al.   PEDIATRIC DRUGS

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

(2013) Maria Ulvestad et al.   BIOCHEMICAL PHARMACOLOGY

Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children

(2013) Tomoyuki Mizuno et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Impact of OATP1B1, MDR1, and CYP3A4 Expression in Liver and Intestine on Interpatient Pharmacokinetic Variability of Atorvastatin in Obese Subjects

(2013) M Ulvestad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy

(2013) Hyung-yul Lee et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Interindividual Variability in the Hepatic Expression of the Human Breast Cancer Resistance Protein (BCRP/ABCG2): Effect of Age, Sex, and Genotype

(2013) Bhagwat Prasad et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Utility of Modeling and Simulation in Drug Development and Regulatory Review

(2013) Shiew-Mei Huang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

An old method facing a new challenge: Re-visiting housekeeping proteins as internal reference control for neuroscience research

(2013) Rena Li et al.   LIFE SCIENCES

Predicting Pharmacokinetic Profiles Using in Silico Derived Parameters

(2013) Natalie A. Hosea et al.   MOLECULAR PHARMACEUTICS

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function

(2013) Maxim Ivanov et al.   GENOME BIOLOGY

Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice

(2012) Julia Yue Cui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PBPK as a tool in regulatory review

(2012) Shiew-Mei Huang   BIOPHARMACEUTICS & DRUG DISPOSITION

Genome-wide study of methotrexate clearance replicates SLCO1B1

(2012) L. B. Ramsey et al.   BLOOD

Highlights from the International Transporter Consortium Second Workshop

(2012) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

(2012) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug disposition and clinical practice in neonates: Cross talk between developmental physiology and pharmacology

(2012) Anne Smits et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients

(2012) Tsuyoshi Fukuda et al.   THERAPEUTIC DRUG MONITORING

RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development

(2012) Julia Yue Cui et al.   TOXICOLOGICAL SCIENCES

Applications of accelerator MS in pediatric drug evaluation

(2012) LT Vuong et al.   Bioanalysis

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding

(2011) Souzan B. Yanni et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

(2011) Neil Parrott et al.   CLINICAL PHARMACOKINETICS

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2011) A. D. Lake et al.   DRUG METABOLISM AND DISPOSITION

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

(2011) Violette Gijsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos

(2011) A. Konieczna et al.   JOURNAL OF MOLECULAR HISTOLOGY

Functional Maturation of Drug Transporters in the Developing, Neonatal, and Postnatal Kidney

(2011) D. E. Sweeney et al.   MOLECULAR PHARMACOLOGY

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

mRNA Expression of MDR1 and Major Metabolising Enzymes in Human Fetal Tissues

(2010) May Fakhoury et al.   Drug Metabolism and Pharmacokinetics

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

ttime: an R Package for Translating the Timing of Brain Development Across Mammalian Species

(2010) Radhakrishnan Nagarajan et al.   NEUROINFORMATICS

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Validation of suitable internal control genes for expression studies in aging

(2009) M. Zampieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies

(2008) SU Yasuda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Expression of Hepatocyte Transporters and Nuclear Receptors in Children With Early and Late-Stage Biliary Atresia

(2008) Huey-Ling Chen et al.   PEDIATRIC RESEARCH

The ontogeny of drug metabolizing enzymes and transporters in the rat

(2008) Loeckie de Zwart et al.   REPRODUCTIVE TOXICOLOGY