Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Bioactive natural products from novel microbial sources

(2015) Victoria L. Challinor et al.   Annals of the New York Academy of Sciences

Genetic Determinants of Reutericyclin Biosynthesis in Lactobacillus reuteri

(2015) Xiaoxi B. Lin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

(2015) Jeremy R. Lohman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

(2014) Alexandra Calteau et al.   BMC GENOMICS

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

(2014) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The leader peptide of mutacin 1140 has distinct structural components compared to related class I lantibiotics

(2014) Jerome Escano et al.   MicrobiologyOpen

BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides

(2013) Auke J. van Heel et al.   NUCLEIC ACIDS RESEARCH

Type III polyketide synthases in natural product biosynthesis

(2012) Dayu Yu et al.   IUBMB LIFE

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

SMU.152 Acts as an Immunity Protein for Mutacin IV

(2012) M. S. Hossain et al.   JOURNAL OF BACTERIOLOGY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Bacteriocins — a viable alternative to antibiotics?

(2012) Paul D. Cotter et al.   NATURE REVIEWS MICROBIOLOGY

Structure and Biosynthesis of the Antibiotic Bottromycin D

(2012) Yanpeng Hou et al.   ORGANIC LETTERS

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

(2012) Nadine Ziemert et al.   PLoS One

Regulation of the Competence Pathway as a Novel Role Associated with a Streptococcal Bacteriocin

(2011) D. Dufour et al.   JOURNAL OF BACTERIOLOGY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium

(2011) Xiaoru Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Genome Mining Demonstrates the Widespread Occurrence of Gene Clusters Encoding Bacteriocins in Cyanobacteria

(2011) Hao Wang et al.   PLoS One

Structure and genetics of circular bacteriocins

(2011) Marco J. van Belkum et al.   TRENDS IN MICROBIOLOGY

Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage

(2010) Annechien Plat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genomic Island TnSmu2 of Streptococcus mutans Harbors a Nonribosomal Peptide Synthetase-Polyketide Synthase Gene Cluster Responsible for the Biosynthesis of Pigments Involved in Oxygen and H2O2 Tolerance

(2010) C. Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Polyketide β-Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase

(2010) Tonia J. Buchholz et al.   CHEMISTRY & BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

(2010) P. Matthew Joyner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence

(2009) Julie A. Perry et al.   MOLECULAR MICROBIOLOGY

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

Frequency and expression of mutacin biosynthesis genes in isolates of Streptococcus mutans with different mutacin-producing phenotypes

(2008) R. U. Kamiya et al.   JOURNAL OF MEDICAL MICROBIOLOGY